scholarly journals Qualitative Determination of Human Chorionic Gonadotropin in Vaginal Washings for the Early Diagnosis of Premature Rupture of Fetal Membranes

2017 ◽  
Vol 39 (07) ◽  
pp. 317-321
Author(s):  
Camila Dartibale ◽  
Nelson Uchimura ◽  
Luiz Nery ◽  
Angelita Schumeish ◽  
Liza Uchimura ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Fetal Membranes ◽  
Vaginal Fluid ◽  
Premature Rupture ◽  
Significant Difference ◽  
Β Hcg ◽  
Hcg Test

Purpose This study aimed to evaluate and validate the qualitative human chorionic gonadotropin β subunit (β-hCG) test of the vaginal fluid washings of pregnant women with premature rupture of fetal membranes (PROM). Methods Cross-sectional study of pregnant women between gestational weeks 24 and 39 who underwent consultations in one of our institutions. They were divided into two groups: group A (pregnant women clinically diagnosed with PROM) and group B (pregnant women without loss of amniotic liquid). The patients were subjected to a vaginal fluid washing with 3 mL of saline solution, which was aspirated subsequently with the same syringe. The solution was immediately sent to the laboratory to perform the vaginal β-hCG test with cut-off points of 10 mIU/mL (β-hCG-10) and/or 25 mIU/mL (β-hCG-25). Results The β-hCG-10 test of the vaginal secretion was performed in 128 cases. The chi-squared test with Yates' correction showed a statistically significant difference between the 2 groups (p = 0.0225). The sensibility, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy parameters were 77.1%, 43.6%, 52.3%; 70.4%; and 58.6% respectively. The β-hCG-25 test of the vaginal washing was performed in 49 cases. The analysis by Fisher's exact test showed a statistically significant difference between the groups (p = 0.0175). The sensibility, specificity, PPV, NPV, and accuracy parameters were 44.4%, 87.1%, 66.6%; 72.9%; and 71.4% respectively. Conclusions The β-hCG-25 test showed better accuracy for the diagnosis of PROM, and can corroborate the early diagnosis of PROM because it is a simple and quick exam.

scholarly journals The value of measurement of vaginal fluid creatinine and beta-human chorionic gonadotropin in the diagnosis of premature rupture of membranes

2021 ◽  
Author(s):  
Zafer Bütün
Keyword(s):  
Predictive Value ◽  
Accurate Method ◽  
Control Group ◽  
Lower Sensitivity ◽  
Vaginal Fluid ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Beta Human Chorionic Gonadotropin ◽  
Significant Difference ◽  
Β Hcg

Objective: The purpose of the present study is to evaluate β-human chorionic go- nadotropin (β-hCG) and creatinine levels in the vaginal fluid regarding to diagnosis of premature rupture of membranes (PROM). Material and Methods: This study was conducted on 150 pregnant women in the third trimester (28–40 weeks). The patients were grouped as: (1) PPROM group (75 cases) and (2) intact membranes as control group (75 cases). Three milliliters of ster- ile normal saline were inserted into the posterior fornix of the vagina and then vaginal fluid was aspirated. Creatinine and β-hCG levels in the vaginal fluid were measured β-hCG and creatinine levels were compared between the two groups. Results: The mean vaginal fluid level in Groups 1 and 2 was 0.60±0.72 (0.37) and 0.22±0.11 (0.2) for creatinine and β-hCG which was positive in 411.69±605.65 (146) and 12.71±24.63 (3.9), respectively. There was a statistically significant difference regarding to mean creatinine and β-hCG levels between two groups (p<0.001). Sen- sitivity, specificity, positive predictive value, negative predictive value, and accuracy were all 66.67%, 96%, 94.3%, 74.3%, and 81.3% for creatinine and 94.6%, 82.6%, 84.52%, 93.94%, and 88.67% for β-hCG in detecting PROM with a cutoff value of 0.21 mg/dl for creatinine and 16 mIU/ml for β-hCG. Conclusion: Measuring of β-hCG level in vaginal fluid is accurate, cheap, and simple methods in the diagnosis of PROM. Furthermore, measuring of creatinine level is a simple and accurate method with a lower sensitivity and accuracy than for β-hCG.

EVALUATION OF HUMAN CHORIONIC GONADOTROPIN IN VAGINAL WASHINGS FOR THE EARLY DIAGNOSIS OF PREMATURE RUPTURE OF FOETAL MEMBRANES: A CLINICAL STUDY

2021 ◽  
pp. 49-50
Author(s):  
Komal Yadav ◽  
Sadhna Mathur ◽  
Surabhi Tomar ◽  
Faizah Yousuf
Keyword(s):  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Demographic Data ◽  
Control Group ◽  
Premature Rupture ◽  
Beta Hcg ◽  
Group 2 ◽  
Group B ◽  
Group 1

Aim: This study is aimed to evaluate and validate the qualitative human chorionic gonadotropin β subunit (β-hCG) test of the vaginal uid washings of pregnant women with premature rupture of fetal membranes (PROM). Materials & Methodology: A total of 60 pregnant women between 26- and 36-weeks' gestation had participated in this study. The patients with leaking from the vagina were designated Group A, the patients with no leaking from the vagina were Group B. After administering 5 cc of normal saline to posterior fornix by sterile injector, a total of 5 cc washing uid was collected. human chorionic gonadotropin were examined on the same day on collected uid and both groups were compared statistically. Result: In the current study 53.4% patients in group 1 and 60.0% patients from control group were between 19-25 years of age group. Majority of patients were unbooked in both groups. 46.6% patients in PROM group and 56.6% patients in control group presents before 34 weeks of gestation. There is no statistical signicance between two groups in terms of demographic data. Beta -HCG values in vaginal uid of Group 1 was signicantly higher than values in Group 2 with cut off value of Beta -HCG as 50mIU/dL. 83.4% patients from Group 1 (PROM Group) shows Beta -HCG value more than 50Miu/dL.

scholarly journals Qualitative Human Chorionic Gonadotropin Testing in Vaginal Fluid for Diagnosis of Preterm Premature Rupture of Membrane

1970 ◽  
Vol 4 (2) ◽  
pp. 28-31
Author(s):  
Reeti Mehra ◽  
Anju Huria ◽  
Beena Mahaur
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Vaginal Fluid ◽  
Premature Rupture ◽  
Preterm Premature Rupture

DOI: http://dx.doi.org/10.3126/njog.v4i2.5043 NJOG 2010 Jan-Feb; 4(2): 28-31

scholarly journals PREMATURE RUPTURE OF MEMBRANES

2018 ◽  
Vol 25 (02) ◽  
pp. 168-172
Author(s):  
Azmeena Azam ◽  
Hafiz Maoz Husnain ◽  
Iqra Marryum
Keyword(s):  
Cross Sectional Study ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Vaginal Fluid ◽  
Effective Management ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Β Hcg ◽  
Hcg Test

Background: Pre-labour rupture of the membranes is one of the most commonclinical presentations in an obstetric setting. Early diagnosis is a major challenge faced byevery obstetrician and key to effective management and prevention of complications. As aresult of PROM, amniotic fluid that provides protection to the developing fetus is lost, exposingit to the outside environment. β-hCG is a hormone secreted by syncytiotrophoblasts found inamniotic fluid that can be studied for the evaluation of PROM. Objectives: To find the DiagnosticAccuracy of β human chorionic gonadotrophin test in vaginal washings taking amniotic fluidpooling as gold standard of diagnosing PROM. Study Design: Cross-sectional study. Setting:Unit II, Department of Obstetrics & Gynecology, Lahore General Hospital, Lahore. Period: Threemonths from January 2017 to March 2017. Material and methods: Females of age 18-40 yearswith gestational age >36weeks (calculated by LMP) complaining of PV leaking were includedin the study. Samples for β-hCG measurements were taken after informed consent. A β-hCGkit (Acu-check) was used for detection of β-hCG in vaginal fluid washings of pregnant women.Results: Diagnostic accuracy of β-hCG test was 91.66%. Sensitivity and specificity of β-hCGtest was 86.66% and 96.66%. Positive predictive and negative predictive value was 96.29% and87.87% respectively. Conclusion: Results of this study showed that for diagnosis of patientshaving PROM, beta human chorionic gonadotrophin (β-hCG) is a reliable, easy and quick test.

Evaluation of Vaginal Fluid b-Human Chorionic Gonadotropin for Diagnosis of Premature Rupture of Membranes

2018 ◽  
Vol 86 (March) ◽  
pp. 597-603
Author(s):  
AHMED M. ABBAS, M.Sc. SHAHINAZ H. EL-SHORBAGY, M.D. ◽  
AMAL S. EL-BANDARY, M.D. AHMED M. EL-ATTAR, M.D.
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Vaginal Fluid ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture

scholarly journals Levels of Maternal Serum Alpha-fetoprotein and Beta Human Chorionic Gonadotropin in HIV Seropositive Pregnant Women Attending Antenatal Care at Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria

2021 ◽  
pp. 32-38
Author(s):  
C. H. Udeogu ◽  
M. C. Ugwu ◽  
J. Okwara ◽  
A. C. Ohale ◽  
O. C. Ike ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Test Group ◽  
Maternal Serum ◽  
Alpha Fetoprotein ◽  
Beta Human Chorionic Gonadotropin ◽  
Serum Alpha Fetoprotein ◽  
Β Hcg ◽  
Hiv Seropositive

HIV infection remains a worrisome pandemic especially in developing countries like Nigeria, with an increasing number of infected women becoming pregnant, with added risk of pregnancy complications such as intrauterine fetal death, neural tube defects, and vertical transmissions. Hence this study assessed the levels of maternal serum alpha-fetoprotein (MSAFP) and beta human chorionic gonadotropin (β-hCG) in HIV seropositive pregnant women, and their implication for maternal and fetal health. A total of 86 patients were recruited for the study from the Antenatal Clinic of Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi.  Forty three were HIV seropositive (Test group), and forty three were HIV seronegative (Control group). Maternal serum alpha-fetoprotein and beta human chorionic gonadotropin levels were assayed by Enzyme Linked Immunosorbent Assay. The results showed that MSAFP levels (3.14±2.80 ng/ml) were significantly lower (P < .05) in HIV infected pregnant women when compared to HIV uninfected pregnant women (4.75±3.68 ng/ml). There was no significant difference in the levels of β-hCG (217.88±63.85mIU/mL) in the test group (P = 0.629) as compared to controls (223.75±47.71 mIU/mL). In the test group, increased CD4 counts were significantly   associated   with   increased MSAFP and β-hCG levels in a positive fashion (P < .05). Increase in Gestational age was also significantly associated with increased β-hCG levels (P < .05). The measurements of MSAFP and β-hCG levels may be used alongside CD4 count in the assessment of maternal and fetal wellbeing. Human Immunodeficiency Virus by reducing the levels of MSAFP in HIV infected pregnant women increases the likelihood of pregnancy complications such as intrauterine fetal death.

scholarly journals Lung neoplasm mimicking as ectopic pregnancy due to paraneoplastic secretion of human chorionic gonadotropin: a case report and literature review

2021 ◽  
Author(s):  
Jin Peng ◽  
Shangge lv ◽  
Lin Liu ◽  
Shuai Feng ◽  
Naidong Xing
Keyword(s):  
Systematic Review ◽  
Ectopic Pregnancy ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Lung Neoplasm ◽  
High Serum ◽  
Pregnancy Test ◽  
Positive Pregnancy Test ◽  
Β Hcg ◽  
Present Systematic Review

Abstract Purpose The present systematic review aimed to examine the relationship between lung neoplasm and human chorionic gonadotropin (HCG). Especially, women with lung neoplasm mimicking as ectopic pregnancy were explored. Methods A rare case of lung neoplasm with high serum β-HCG, which was initially thought to be ectopic pregnancy, was reported. A literature search was performed of the US National Library of Medicine (MEDLINE), EMBASE, PubMed, and the Cochrane Database of Systematic Reviews using appropriate keywords and subject headings to February 2020. Results Studies assessed lung neoplasm patients with positive HCG were included. Twenty studies, including 24 patients, were included. These cases illustrate the importance of considering the possibility of paraneoplastic secretion of β-HCG in patients who have a positive pregnancy test. This may prevent a delay in the diagnosis and treatment of malignancy in young women. Of the 24 cases, only 7 (29.17%) were managed surgically; others were managed conservatively or with chemotherapy or radiation. Conclusion The present systematic review shows the need to re-awaken awareness and high index of suspicion to lung neoplasm diagnosis in patients with positive pregnancy test.

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