Evaluation of a radiolabeled somatostatin analog (I-123 octreotide) in the detection and localization of carcinoid and islet cell tumors.

Radiology ◽  
1993 ◽  
Vol 187 (1) ◽  
pp. 129-133 ◽  
Author(s):  
L K Kvols ◽  
M L Brown ◽  
M K O'Connor ◽  
J C Hung ◽  
R J Hayostek ◽  
...  
Keyword(s):  
Islet Cell ◽  
Somatostatin Analog ◽  
Islet Cell Tumors ◽  
Radiolabeled Somatostatin Analog ◽  
Detection And Localization

Use of long-acting somatostatin analog SMS 201-995 in patients with pancreatic islet cell tumors

1989 ◽  
Vol 34 (S3) ◽  
pp. S28-S39 ◽  
Author(s):  
Paul N. Maton ◽  
Jerry D. Gardner ◽  
Robert T. Jensen
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Somatostatin Analog ◽  
Islet Cell Tumors ◽  
Pancreatic Islet Cell ◽  
Pancreatic Islet Cell Tumors ◽  
Long Acting

Functioning islet cell tumor of the pancreas

1997 ◽  
Vol 38 (1) ◽  
pp. 135-138 ◽  
Author(s):  
M. J. Chung ◽  
B. I. Choi ◽  
J. K. Han ◽  
J. W. Chung ◽  
M. C. Han ◽  
...  
Keyword(s):  
Islet Cell ◽  
Late Phase ◽  
Islet Cell Tumor ◽  
Ct Scanning ◽  
Spiral Ct ◽  
Arterial Phase ◽  
Islet Cell Tumors ◽  
Contrast Enhanced ◽  
Projection Images ◽  
Detection And Localization

Purpose: The purpose of this study was to evaluate the usefulness of dynamic spiral CT, including multidimensional reformation, in the detection and localization of islet cell tumors of the pancreas. Material and Methods: Seven patients with histopathologically proven functioning islet cell tumors of the pancreas were studied with 2-phase contrast-enhanced spiral CT. Scanning of the arterial phase and late phase was started 30 s and 180 s, respectively, after injection of 100 ml of contrast medium at a rate of 3 ml/s. Results: Axial images in the arterial phase depicted the lesions in 5 patients, but in the late phase in only one patient. Multiplanar reformatted images of the arterial phase depicted the lesions in all 7 patients. Maximal intensity projection images demonstrated all lesions with information of their relationship to the vascular structure. Conclusion: Dynamic spiral CT with scanning during the arterial phase and retrospective multidimensional reformation is useful for preoperative detection and localization of small islet cell tumors of the pancreas.

Ulcerogenic Tumors of the Pancreas

1968 ◽  
Vol 26 ◽  
pp. 186-187
Author(s):  
J. C. Garancis ◽  
J. F. Kuzma ◽  
S. D. Wilson ◽  
E. H. Ellison
Keyword(s):  
Endoplasmic Reticulum ◽  
Tumor Cells ◽  
Islet Cell ◽  
Disease Process ◽  
Central Core ◽  
Islet Cell Tumors ◽  
Opaque Zone ◽  
Granular Form ◽  
Zollinger Ellison Syndrome

It has been proposed that a gastrin-like hormone elaborated by non-beta islet tumors of the pancreas may be responsible for a fulminating ulcer diathesis. Subsequently, a potent gastric secretagogue was isolated from ulcerogenic tumors of the pancreas. This disease process is known now as “Zollinger-Ellison syndrome”.In our studies of two cases of Zollinger-Ellison syndrome, pancreatic lesions were identified as alpha islet cell tumors (Fig. 1). Tumor cells were fairly uniform. The sizes of the alpha granules were not significantly different, but their number and distribution varied greatly from one cell to another. Each granule consisted of a round, highly dense central core, separated from the limiting membrane by an opaque zone. The granular form of the endoplasmic reticulum was particularly prominent. Numerous mitochondria, round or elongated, were dispersed throughout the cytoplasm. Individual or clusters of lysosomes were observed in the majority of cells.

Islet Cell Tumors of the Pancreas

1994 ◽  
Vol 23 (1) ◽  
pp. 53-65 ◽  
Author(s):  
Rena Vassilopoulou-Sellin ◽  
Jaffer Ajani
Keyword(s):  
Islet Cell ◽  
Islet Cell Tumors

Diarrhea associated with pancreatic islet-cell tumors

1964 ◽  
Vol 9 (2) ◽  
pp. 97-108 ◽  
Author(s):  
Julien Deleu ◽  
Hendrik Tytgat ◽  
Guy E. Goidsenhoven
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Tumors ◽  
Pancreatic Islet Cell ◽  
Pancreatic Islet Cell Tumors

scholarly journals Non-Islet Origin of Pancreatic Islet Cell Tumors

2004 ◽  
Vol 89 (4) ◽  
pp. 1934-1938 ◽  
Author(s):  
Alexander O. Vortmeyer ◽  
Steve Huang ◽  
Irina Lubensky ◽  
Zhengping Zhuang
Keyword(s):  
Pancreatic Islet ◽  
Islet Cell ◽  
Islet Cell Tumors ◽  
Pancreatic Islet Cell ◽  
Pancreatic Islet Cell Tumors

scholarly journals Immunohistochemistry of Pancreatic Islet Cell Tumors in the Ferret (Mustela putorius furo)

1997 ◽  
Vol 34 (5) ◽  
pp. 387-393 ◽  
Author(s):  
G. A. Andrews ◽  
N. C. Myers ◽  
C. Chard-Bergstrom
Keyword(s):  
Pancreatic Islets ◽  
Pancreatic Islet ◽  
Pancreatic Polypeptide ◽  
Islet Cell ◽  
Islet Cells ◽  
Neuron Specific Enolase ◽  
Islet Cell Tumors ◽  
Pancreatic Islet Cell ◽  
Formalin Fixed Paraffin Embedded ◽  
Pancreatic Islet Cell Tumors

Twenty-two pancreatic islet cell tumors and normal pancreatic islets from ferrets were evaluated by immunohistochemistry for expression of the peptide hormones insulin, somatostatin, glucagon, and pancreatic polypeptide (PP) and the neuroendocrine markers chromogranin A (CgA) and neuron-specific enolase (NSE). In normal pancreatic islets, the majority of cells stained strongly with CgA and NSE. A cells, B cells, D cells, and PP cells stained strongly with glucagon, insulin, somatostatin, and PP, respectively. All 22 tumors stained with CgA and NSE. The proportion of cells within tumors staining for CgA was variable, but more than half of the cells stained positively in 18 of the tumors. The intensity of staining for CgA was strong (reactivity equivalent to or greater than normal islet cells in adjacent tissue) in 11 moderate in six, and weak in five of the tumors. All tumors stained for NSE, with ≥50% of the cells staining in 21 of the tumors, and the intensity of staining was strong in 18 of the tumors. Twenty of 22 tumors stained positively for insulin, with ≥50% of the cells staining in 19 of them. The intensity of staining for insulin was strong in 12, moderate in seven, and weak in one of the tumors. Approximately ≤1% of the cells in 15 of 22 tumors stained for somatostatin, five tumors stained for pancreatic polypeptide, and three tumors stained for glucagon. These data indicate that the majority of islet cell tumors of ferrets express immunohistochemically detectable insulin. CgA and NSE are both useful general markers for such tumors, including those that are insulin negative. Commercially available antisera to CgA, NSE, insulin, glucagon, somatostatin, and PP work well in formalin-fixed, paraffin-embedded tissue for immunophenotyping islet cell tumors in the ferret.

Tailored imaging of islet cell tumors of the pancreas amidst increasing options

2012 ◽  
Vol 82 (2) ◽  
pp. 213-226 ◽  
Author(s):  
Helle-Brit Fiebrich ◽  
Sophie J. van Asselt ◽  
Adrienne H. Brouwers ◽  
Hendrik M. van Dullemen ◽  
Milan E.J. Pijl ◽  
...  
Keyword(s):  
Islet Cell ◽  
Islet Cell Tumors

Insulin and glucagon in rats with Islet cell tumors Induced by small doses of streptozofoclii

1981 ◽  
Vol 59 (8) ◽  
pp. 818-823 ◽  
Author(s):  
Gen Yoshino ◽  
Tsutomu Kazumi ◽  
Soichiro Morita ◽  
Shighaki Baba
Keyword(s):  
Plasma Glucose ◽  
Islet Cell ◽  
Insulin Response ◽  
Oral Glucose ◽  
Islet Cell Tumors ◽  
Glucose Levels ◽  
Tumor Bearing ◽  
Small Doses ◽  
Wet Weight ◽  
Glucose Plasma

Plasma insulin and glucagon responses to oral glucose loading were examined in rats with islet cell tumors induced by a single intravenous injection of streptozotocin (30 or 40 mg/kg body weight). Twenty-four macroscopic and six microscopic tumors occurred in 21 rats. In 15 of 21 tumor-bearing rats, there was exaggerated insulin release in response to oral glucose. Plasma glucose levels did not rise with the oral glucose load and were comparable to those seen in normal animals. Hence these rats are described as having "responsive tumors." In six rats with "nonresponsive tumors" there was no insulin response and the plasma glucose levels rose. No significant differences in plasma glucagon levels were observed between the two groups. Nonresponsive tumors as well as responsive tumors contained a significant amount of extractable insulin (17.68 ± 8.60 and 35.07 ± 10.05 mg/g wet weight, respectively) and detectable amounts of immunoreactive glucagon (1.47 ± 0.61 and 2.24 ± 0.67 μg/g wet weight, respectively).These results suggest that a small dose of streptozotocin produces two types of islet cell tumors. One is insulin producing and insulin secreting whereas the other is insulin producing but not insulin secreting.

Intraoperative Detection of a Bronchial Carcinoid With a Radiolabeled Somatostatin Analog

CHEST Journal ◽  
2002 ◽  
Vol 121 (3) ◽  
pp. 985-988 ◽  
Author(s):  
Jaime A. Rodriguez ◽  
Michael O. Meyers ◽  
Tomas H. Jacome ◽  
Paul Failla ◽  
Lynn H. Harrison
Keyword(s):  
Somatostatin Analog ◽  
Bronchial Carcinoid ◽  
Intraoperative Detection ◽  
Radiolabeled Somatostatin Analog
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