scholarly journals Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling

2018 ◽  
Vol 314 (4) ◽  
pp. C389-C403 ◽  
Author(s):  
Kristoffer B. Sugg ◽  
James F. Markworth ◽  
Nathaniel P. Disser ◽  
Andrew M. Rizzi ◽  
Jeffrey R. Talarek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Biological Activities ◽  
Growth Factor Receptor ◽  
Normal Growth ◽  
Platelet Derived Growth Factor ◽  
Growth And Remodeling ◽  
Fibroblast Migration ◽  
And Migration ◽  
Phosphoinositide 3 Kinase

Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in the fundamental biological activities of many cells that compose musculoskeletal tissues. However, little is known about the role of PDGFR signaling during tendon growth and remodeling in adult animals. Using the hindlimb synergist ablation model of tendon growth, our objectives were to determine the role of PDGFR signaling in the adaptation of tendons subjected to a mechanical growth stimulus, as well as to investigate the biological mechanisms behind this response. We demonstrate that both PDGFRs, PDGFRα and PDGFRβ, are expressed in tendon fibroblasts and that the inhibition of PDGFR signaling suppresses the normal growth of tendon tissue in response to mechanical growth cues due to defects in fibroblast proliferation and migration. We also identify membrane type-1 matrix metalloproteinase (MT1-MMP) as an essential proteinase for the migration of tendon fibroblasts through their extracellular matrix. Furthermore, we report that MT1-MMP translation is regulated by phosphoinositide 3-kinase/Akt signaling, while ERK1/2 controls posttranslational trafficking of MT1-MMP to the plasma membrane of tendon fibroblasts. Taken together, these findings demonstrate that PDGFR signaling is necessary for postnatal tendon growth and remodeling and that MT1-MMP is a critical mediator of tendon fibroblast migration and a potential target for the treatment of tendon injuries and diseases.

scholarly journals Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling

2017 ◽  
Author(s):  
Kristoffer B Sugg ◽  
James F Markworth ◽  
Nathaniel P Disser ◽  
Andrew M Rizzi ◽  
Jeffrey R Talarek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Biological Activities ◽  
Growth Factor Receptor ◽  
Normal Growth ◽  
Platelet Derived Growth Factor ◽  
Growth And Remodeling ◽  
Fibroblast Migration ◽  
Membrane Type ◽  
And Migration

ABSTRACTPlatelet-derived growth factor receptor (PDGFR) signaling plays an important role in the fundamental biological activities of many cells that compose musculoskeletal tissues. However, little is known about the role of PDGFR signaling during tendon growth and remodeling in adult animals. Using the hindlimb synergist ablation model of tendon growth, our objectives were to determine the role of PDGFR signaling in the adaptation of tendons subjected to a mechanical growth stimulus, as well as to investigate the biological mechanisms behind this response. We demonstrate that both PDGFRs, PDGFRα and PDGFRβ, are expressed in tendon fibroblasts, and that the inhibition of PDGFR signaling suppresses the normal growth of tendon tissue in response to mechanical growth cues due to defects in fibroblast proliferation and migration. We also identify that membrane type-1 matrix metalloproteinase (MT1-MMP) as an essential proteinase for the migration of tendon fibroblasts through their extracellular matrix. Furthermore, we report that MT1-MMP translation is regulated by PI3K/Akt signaling, while ERK1/2 controls post-translational trafficking of MT1-MMP to the plasma membrane of tendon fibroblasts. Taken together, these findings demonstrate that PDGFR signaling is necessary for postnatal tendon growth and remodeling, and that MT1-MMP is a critical mediator of tendon fibroblast migration and a potential target for the treatment of tendon injuries and diseases.

The Role of Platelet-Derived Growth Factor Receptor in Eotaxin Signaling of Eosinophils

2006 ◽  
Vol 140 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Tetsuya Adachi ◽  
Satoko Hanaka ◽  
Tomoko Yano ◽  
Koichi Yamamura ◽  
Hisanao Yoshihara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor

scholarly journals Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 441 ◽  
Author(s):  
Yvan Torrente ◽  
Pamela Bella ◽  
Luana Tripodi ◽  
Chiara Villa ◽  
Andrea Farini
Keyword(s):  
Growth Factor ◽  
Growth Factor Receptor ◽  
Muscle Disease ◽  
Insulin Like Growth Factor ◽  
Related Disease ◽  
Research Findings ◽  
Novel Approaches ◽  
And Migration ◽  
Muscle Homeostasis

The insulin-like growth factor 2 receptor (IGF2R) plays a major role in binding and regulating the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2). IGF2/IGF2R interaction influences cell growth, survival, and migration in normal tissue development, and the deregulation of IGF2R expression has been associated with growth-related disease and cancer. IGF2R overexpression has been implicated in heart and muscle disease progression. Recent research findings suggest novel approaches to target IGF2R action. This review highlights recent advances in the understanding of the IGF2R structure and pathways related to muscle homeostasis.

Two functionally distinct pools of Src kinases for PDGF receptor signalling

2005 ◽  
Vol 33 (6) ◽  
pp. 1313-1315 ◽  
Author(s):  
L. Veracini ◽  
M. Franco ◽  
A. Boureux ◽  
V. Simon ◽  
S. Roche ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Tyrosine Kinases ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Pdgf Receptor ◽  
Actin Assembly ◽  
Cell Responses ◽  
Receptor Signalling ◽  
And Migration

The cytoplasmic tyrosine kinases of the Src family (SFK) play important roles in cell responses induced by growth factors, including cell growth, survival and migration. Here, we review how SFK participate in PDGF (platelet-derived growth factor) receptor signalling leading to DNA synthesis and actin assembly. Furthermore, evidence for a spatial compartmentalization of SFK signalling is also discussed.

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