scholarly journals Role of Insulin-Like Growth Factor Receptor 2 across Muscle Homeostasis: Implications for Treating Muscular Dystrophy

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 441 ◽  
Author(s):  
Yvan Torrente ◽  
Pamela Bella ◽  
Luana Tripodi ◽  
Chiara Villa ◽  
Andrea Farini
Keyword(s):  
Growth Factor ◽  
Growth Factor Receptor ◽  
Muscle Disease ◽  
Insulin Like Growth Factor ◽  
Related Disease ◽  
Research Findings ◽  
Novel Approaches ◽  
And Migration ◽  
Muscle Homeostasis

The insulin-like growth factor 2 receptor (IGF2R) plays a major role in binding and regulating the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2). IGF2/IGF2R interaction influences cell growth, survival, and migration in normal tissue development, and the deregulation of IGF2R expression has been associated with growth-related disease and cancer. IGF2R overexpression has been implicated in heart and muscle disease progression. Recent research findings suggest novel approaches to target IGF2R action. This review highlights recent advances in the understanding of the IGF2R structure and pathways related to muscle homeostasis.

Prognostic role of insulin-like growth factor receptor-1 expression in small cell lung cancer

Apmis ◽  
2009 ◽  
Vol 117 (12) ◽  
pp. 861-869 ◽  
Author(s):  
MYUNG HEE CHANG ◽  
JEEYUN LEE ◽  
JOUNGHO HAN ◽  
YEON HEE PARK ◽  
JIN SEOK AHN ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Growth Factor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Insulin Like Growth Factor ◽  
Small Cell Lung ◽  
Prognostic Role

scholarly journals Postnatal Tendon Growth and Remodeling Requires Platelet-Derived Growth Factor Receptor Signaling

2017 ◽  
Author(s):  
Kristoffer B Sugg ◽  
James F Markworth ◽  
Nathaniel P Disser ◽  
Andrew M Rizzi ◽  
Jeffrey R Talarek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Biological Activities ◽  
Growth Factor Receptor ◽  
Normal Growth ◽  
Platelet Derived Growth Factor ◽  
Growth And Remodeling ◽  
Fibroblast Migration ◽  
Membrane Type ◽  
And Migration

ABSTRACTPlatelet-derived growth factor receptor (PDGFR) signaling plays an important role in the fundamental biological activities of many cells that compose musculoskeletal tissues. However, little is known about the role of PDGFR signaling during tendon growth and remodeling in adult animals. Using the hindlimb synergist ablation model of tendon growth, our objectives were to determine the role of PDGFR signaling in the adaptation of tendons subjected to a mechanical growth stimulus, as well as to investigate the biological mechanisms behind this response. We demonstrate that both PDGFRs, PDGFRα and PDGFRβ, are expressed in tendon fibroblasts, and that the inhibition of PDGFR signaling suppresses the normal growth of tendon tissue in response to mechanical growth cues due to defects in fibroblast proliferation and migration. We also identify that membrane type-1 matrix metalloproteinase (MT1-MMP) as an essential proteinase for the migration of tendon fibroblasts through their extracellular matrix. Furthermore, we report that MT1-MMP translation is regulated by PI3K/Akt signaling, while ERK1/2 controls post-translational trafficking of MT1-MMP to the plasma membrane of tendon fibroblasts. Taken together, these findings demonstrate that PDGFR signaling is necessary for postnatal tendon growth and remodeling, and that MT1-MMP is a critical mediator of tendon fibroblast migration and a potential target for the treatment of tendon injuries and diseases.

The role of the type 1 insulin-like growth factor receptor in bladder cancer

2003 ◽  
Vol 2 (6) ◽  
pp. 52
Author(s):  
M.A Rochester ◽  
N.S Patel ◽  
G.O Hellawell ◽  
S.F Brewster ◽  
V.M Macaulay
Keyword(s):  
Bladder Cancer ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Insulin Like Growth Factor

scholarly journals Postnatal tendon growth and remodeling require platelet-derived growth factor receptor signaling

2018 ◽  
Vol 314 (4) ◽  
pp. C389-C403 ◽  
Author(s):  
Kristoffer B. Sugg ◽  
James F. Markworth ◽  
Nathaniel P. Disser ◽  
Andrew M. Rizzi ◽  
Jeffrey R. Talarek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Biological Activities ◽  
Growth Factor Receptor ◽  
Normal Growth ◽  
Platelet Derived Growth Factor ◽  
Growth And Remodeling ◽  
Fibroblast Migration ◽  
And Migration ◽  
Phosphoinositide 3 Kinase

Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in the fundamental biological activities of many cells that compose musculoskeletal tissues. However, little is known about the role of PDGFR signaling during tendon growth and remodeling in adult animals. Using the hindlimb synergist ablation model of tendon growth, our objectives were to determine the role of PDGFR signaling in the adaptation of tendons subjected to a mechanical growth stimulus, as well as to investigate the biological mechanisms behind this response. We demonstrate that both PDGFRs, PDGFRα and PDGFRβ, are expressed in tendon fibroblasts and that the inhibition of PDGFR signaling suppresses the normal growth of tendon tissue in response to mechanical growth cues due to defects in fibroblast proliferation and migration. We also identify membrane type-1 matrix metalloproteinase (MT1-MMP) as an essential proteinase for the migration of tendon fibroblasts through their extracellular matrix. Furthermore, we report that MT1-MMP translation is regulated by phosphoinositide 3-kinase/Akt signaling, while ERK1/2 controls posttranslational trafficking of MT1-MMP to the plasma membrane of tendon fibroblasts. Taken together, these findings demonstrate that PDGFR signaling is necessary for postnatal tendon growth and remodeling and that MT1-MMP is a critical mediator of tendon fibroblast migration and a potential target for the treatment of tendon injuries and diseases.

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