scholarly journals Modulation of pharyngeal swallowing by bolus volume and viscosity

2021 ◽  
Vol 320 (1) ◽  
pp. G43-G53
Author(s):  
Lara Ferris ◽  
Sebastian Doeltgen ◽  
Charles Cock ◽  
Nathalie Rommel ◽  
Mistyka Schar ◽  
...  
Keyword(s):  
Oropharyngeal Dysphagia ◽  
Intraluminal Pressure ◽  
Physiological Measures ◽  
Bolus Volume ◽  
Study Methods ◽  
Wide Range ◽  
Diagnostic Framework ◽  
Pharyngeal Swallowing

The neuromodulation of the healthy oropharyngeal swallow response was described in relation to bolus volume and viscosity challenges, using intraluminal pressure and impedance topography methods. Among a wide range of physiological measures, those indicative of distension pressure, luminal opening, and flow timing were most significantly altered by bolus condition and therefore considered potential markers of swallow neuromodulation. The study methods and associated findings inform a diagnostic framework for swallow assessment in patients with oropharyngeal dysphagia.

scholarly journals Increased Bolus Volume Effect on Delayed Pharyngeal Swallowing Response in Post-stroke Oropharyngeal Dysphagia: A Pilot Study

2016 ◽  
Vol 40 (6) ◽  
pp. 1018 ◽  
Author(s):  
Jin-Woo Park ◽  
Gyu-Jeong Sim ◽  
Dong-Chan Yang ◽  
Kyoung-Hwan Lee ◽  
Ji-Hea Chang ◽  
...  
Keyword(s):  
Pilot Study ◽  
Oropharyngeal Dysphagia ◽  
Volume Effect ◽  
Bolus Volume ◽  
Post Stroke ◽  
Pharyngeal Swallowing

scholarly journals Determinants of valve gating in collecting lymphatic vessels from rat mesentery

2011 ◽  
Vol 301 (1) ◽  
pp. H48-H60 ◽  
Author(s):  
Michael J. Davis ◽  
Elaheh Rahbar ◽  
Anatoliy A. Gashev ◽  
David C. Zawieja ◽  
James E. Moore
Keyword(s):  
Pressure Gradient ◽  
Muscle Tone ◽  
Lymphatic Vessels ◽  
Vessel Diameter ◽  
Intraluminal Pressure ◽  
Pressure Gradients ◽  
Rat Mesentery ◽  
Temporal Relationships ◽  
Wide Range ◽  
Valve Opening

Secondary lymphatic valves are essential for minimizing backflow of lymph and are presumed to gate passively according to the instantaneous trans-valve pressure gradient. We hypothesized that valve gating is also modulated by vessel distention, which could alter leaflet stiffness and coaptation. To test this hypothesis, we devised protocols to measure the small pressure gradients required to open or close lymphatic valves and determine if the gradients varied as a function of vessel diameter. Lymphatic vessels were isolated from rat mesentery, cannulated, and pressurized using a servo-control system. Detection of valve leaflet position simultaneously with diameter and intraluminal pressure changes in two-valve segments revealed the detailed temporal relationships between these parameters during the lymphatic contraction cycle. The timing of valve movements was similar to that of cardiac valves, but only when lymphatic vessel afterload was elevated. The pressure gradients required to open or close a valve were determined in one-valve segments during slow, ramp-wise pressure elevation, either from the input or output side of the valve. Tests were conducted over a wide range of baseline pressures (and thus diameters) in passive vessels as well as in vessels with two levels of imposed tone. Surprisingly, the pressure gradient required for valve closure varied >20-fold (0.1–2.2 cmH2O) as a passive vessel progressively distended. Similarly, the pressure gradient required for valve opening varied sixfold with vessel distention. Finally, our functional evidence supports the concept that lymphatic muscle tone exerts an indirect effect on valve gating.

scholarly journals Comparison of wearable and clinical devices for acquisition of peripheral nervous system signals

2020 ◽  
Author(s):  
Andrea Bizzego ◽  
Giulio Gabrieli ◽  
Cesare Furlanello ◽  
Gianluca Esposito
Keyword(s):  
Nervous System ◽  
Electrodermal Activity ◽  
Reliability And Validity ◽  
Access Point ◽  
Signal Quality ◽  
Physiological Measures ◽  
Wide Range ◽  
Data Analysis Procedure ◽  
Standard Set

AbstractA key access point to the functioning of the Autonomic Nervous System is the investigation of peripheral signals. Wearable Devices (WDs) enable the acquisition and quantification of peripheral signals in a wide range of contexts, from personal uses to scientific research. WDs have lower costs and higher portability than medical-grade devices. But achievable data quality can be lower, subject to artifacts due to body movements and data losses. It is therefore crucial to evaluate the reliability and validity of WDs before their use in research. In this study we introduce a data analysis procedure for the assessment of WDs for multivariate physiological signals. The quality of cardiac and Electrodermal Activity signals is validated with a standard set of Signal Quality Indicators. The pipeline is available as a collection of open source Python scripts based on the pyphysio package. We apply the indicators for the analysis of signal quality on data simultaneously recorded from a clinical-grade device and two WDs. The dataset provides signals of 6 different physiological measures collected from 18 subjects with WDs. This study indicates the need of validating the use of WD in experimental settings for research and the importance of both technological and signal processing aspects to obtain reliable signals and reproducibility of results.

Ureteral Urine Transport: Changes in Bolus Volume, Peristaltic Frequency, Intraluminal Pressure and Volume of Flow Resulting from Autonomic Drugs

1987 ◽  
Vol 137 (1) ◽  
pp. 132-135 ◽  
Author(s):  
Takashi Morita ◽  
Ikuo Wada ◽  
Hideaki Saeki ◽  
Seigi Tsuchida ◽  
Robert M. Weiss
Keyword(s):  
Intraluminal Pressure ◽  
Bolus Volume

Thin Liquid Bolus Volume Alters Pharyngeal Swallowing: Kinematic Analysis Using 3D Dynamic CT

Dysphagia ◽  
2022 ◽  
Author(s):  
Kannit Pongpipatpaiboon ◽  
Yoko Inamoto ◽  
Keiko Aihara ◽  
Hitoshi Kagaya ◽  
Seiko Shibata ◽  
...  
Keyword(s):  
Kinematic Analysis ◽  
Dynamic Ct ◽  
Bolus Volume ◽  
Pharyngeal Swallowing ◽  
Liquid Bolus

Effect of bolus volume on pharyngeal swallowing assessed by high-resolution manometry

2014 ◽  
Vol 128 ◽  
pp. 46-51 ◽  
Author(s):  
Tuo Lin ◽  
Guangqing Xu ◽  
Zulin Dou ◽  
Yue Lan ◽  
Fan Yu ◽  
...  
Keyword(s):  
High Resolution ◽  
Bolus Volume ◽  
High Resolution Manometry ◽  
Pharyngeal Swallowing

Airway Closure Delay: The Predominant Pathophysiology in Reflux-Associated Dysphagia

2019 ◽  
Vol 160 (5) ◽  
pp. 885-890 ◽  
Author(s):  
Katherine A. Kendall
Keyword(s):  
Tertiary Care ◽  
Oropharyngeal Dysphagia ◽  
Retrospective Chart Review ◽  
Upper Esophageal Sphincter ◽  
Barium Swallow ◽  
Airway Closure ◽  
Swallowing Function ◽  
Pharyngeal Transit ◽  
Pharyngeal Swallowing ◽  
The Impact

Objective Reflux disease is common in patients with oropharyngeal dysphagia, but the impact of reflux on oropharyngeal swallowing physiology is not known. This study uses objective measures of swallowing function from modified barium swallow studies to describe the pathophysiology of dysphagia in a group of patients whose only associated condition is reflux. Study Design Retrospective chart review. Setting Tertiary care voice and swallowing clinic. Subjects and Methods The Swallowing Database at the University of Utah was queried for patients with a diagnosis of reflux without additional conditions known to affect swallowing function. Pharyngeal transit time (TPT), distance of hyoid elevation (Hmax), maximum opening size of the upper esophageal sphincter (UESmax), area of pharynx at maximum constriction (PAmax), airway closure timing relative to the arrival of the bolus at the UES, and penetration/aspiration (Pen/Asp) score were assessed. Results Of the 122 patients who met inclusion criteria for the study, 42% had normal pharyngeal swallowing function, 57% had at least 1 abnormal swallowing measure, and 47.5% demonstrated a delay in airway closure relative to arrival of the bolus at the UES on at least 1 swallow. The incidence of prolonged TPT, diminished Hmax, poor UESmax, and enlarged PAmax were 2.5%, 8%, 4%, and 11.5%, respectively. Sixty percent with a delay in airway closure had a normal Pen/Asp score. Conclusion A delay in airway closure relative to the arrival of the bolus at the UES is the most common abnormality of swallowing function found in patients with reflux-associated dysphagia but may not be identified using the Pen/Asp score.

Effects of remifentanil on pharyngeal swallowing and esophageal motility - no impact of different bolus volumes, and partial antagonism by methylnaltrexone

2021 ◽  
Author(s):  
Per Cajander ◽  
Taher I. Omari ◽  
Charles Cock ◽  
Anders Magnuson ◽  
Mika Scheinin ◽  
...  
Keyword(s):  
Esophageal Pressure ◽  
Opioid Antagonist ◽  
Bolus Volume ◽  
Esophageal Function ◽  
Swallowing Dysfunction ◽  
Underlying Causes ◽  
Pharyngeal Swallowing ◽  
Flow Variables ◽  
Double Blinded ◽  
Study Participants

Background Remifentanil impairs swallowing, and disturbed accommodation to bolus volume may be one of the underlying causes. It is not fully understood whether remifentanil-induced swallowing dysfunction is mediated by peripheral or central mechanisms. Aims To investigate if remifentanil-induced swallowing dysfunction is dependent on the bolus volume and whether the effect of remifentanil could be counteracted by methylnaltrexone, a peripherally acting opioid antagonist. Methods Nineteen healthy volunteers were included in this double-blinded, randomized, placebo-controlled, crossover study. Study participants received target-controlled remifentanil infusions and placebo infusions in a randomized order. Methylnaltrexone was administered by intravenous injection of doses of 0.3 mg/kg. Recordings of pressure and impedance data were acquired using a combined manometry and impedance solid state catheter. Data was analyzed from three series of bolus swallows, baseline, during remifentanil exposure, and 15 min after methylnaltrexone. Results Remifentanil induced significant effects on multiple pharyngeal and esophageal function parameters. No significant differences in remifentanil-induced swallowing dysfunction related to different bolus volumes were found. Pharyngeal effects of remifentanil were not significantly counteracted by methylnaltrexone, whereas on the distal esophageal level, effects on distension pressures were counteracted. Conclusions Changes in pharyngeal and esophageal pressure flow variables were consistent with previous results on remifentanil-induced swallowing dysfunction, and uniform across all bolus volumes. The effects of remifentanil on the pharyngeal level and on the proximal esophagus appear to be predominantly centrally mediated, whereas the effects of remifentanil on the distal esophagus may be mediated by both central and peripheral mechanisms.

Generalization of the Bolus Volume Effect on Piezoelectric Sensor Signals during Pharyngeal Swallowing in Normal Subjects

2011 ◽  
Vol 53 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Yozo Miyaoka ◽  
Ichiro Ashida ◽  
Shin-ya Kawakami ◽  
Yuko Tamaki ◽  
Satomi Miyaoka
Keyword(s):  
Piezoelectric Sensor ◽  
Normal Subjects ◽  
Volume Effect ◽  
Bolus Volume ◽  
Sensor Signals ◽  
Pharyngeal Swallowing

scholarly journals Comparison of Wearable and Clinical Devices for Acquisition of Peripheral Nervous System Signals

Sensors ◽  
2020 ◽  
Vol 20 (23) ◽  
pp. 6778
Author(s):  
Andrea Bizzego ◽  
Giulio Gabrieli ◽  
Cesare Furlanello ◽  
Gianluca Esposito
Keyword(s):  
Nervous System ◽  
Electrodermal Activity ◽  
Reliability And Validity ◽  
Access Point ◽  
Signal Quality ◽  
Physiological Measures ◽  
Wide Range ◽  
Data Analysis Procedure ◽  
Standard Set

A key access point to the functioning of the autonomic nervous system is the investigation of peripheral signals. Wearable devices (WDs) enable the acquisition and quantification of peripheral signals in a wide range of contexts, from personal uses to scientific research. WDs have lower costs and higher portability than medical-grade devices. However, the achievable data quality can be lower, and data are subject to artifacts due to body movements and data losses. It is therefore crucial to evaluate the reliability and validity of WDs before their use in research. In this study, we introduce a data analysis procedure for the assessment of WDs for multivariate physiological signals. The quality of cardiac and electrodermal activity signals is validated with a standard set of signal quality indicators. The pipeline is available as a collection of open source Python scripts based on the pyphysio package. We apply the indicators for the analysis of signal quality on data simultaneously recorded from a clinical-grade device and two WDs. The dataset provides signals of six different physiological measures collected from 18 subjects with WDs. This study indicates the need to validate the use of WDs in experimental settings for research and the importance of both technological and signal processing aspects to obtain reliable signals and reproducible results.

Sign in / Sign up

Export Citation Format

Share Document