Submandibular salivary gland weight increase by administration of isoproterenol to rats

1962 ◽  
Vol 202 (3) ◽  
pp. 425-428 ◽  
Author(s):  
Herbert Wells
Keyword(s):  
Salivary Gland ◽  
Linear Relationship ◽  
Submandibular Gland ◽  
Superior Cervical Ganglion ◽  
Submandibular Salivary Gland ◽  
Lower Incisor ◽  
Gland Weight ◽  
Submandibular Salivary Glands ◽  
Percent Increase ◽  
Cervical Ganglion

Administration of isoproterenol, like amputation of lower incisor teeth, resulted in a marked increase in both the fresh and dry weights of the submandibular salivary glands of rats. There was a linear relationship between the percent increase in gland weight and the dose of isoproterenol between 10 and 160 mg/kg/day. Ten days after cessation of isoproterenol administration, the weight of the enlarged glands had receded to control levels. Although prior unilateral extirpation of the superior cervical ganglion inhibited the response to incisor amputation of the submandibular gland on the operated side, both glands enlarged to the same extent following administration of isoproterenol. When isoproterenol administration was combined with amputation of the incisors, the effects on gland weight were additive.

scholarly journals Unusual Variations in Path of Accessory Submandibular Salivary Gland Duct in Comparison with Main Submandibular Salivary Gland Duct

2018 ◽  
Vol 26 (2) ◽  
Author(s):  
Anita Anita ◽  
Saryu Sain ◽  
Amrita Gupta
Keyword(s):  
Salivary Gland ◽  
Submandibular Gland ◽  
Submandibular Salivary Gland ◽  
Main Duct ◽  
Mylohyoid Muscle ◽  
Lower Incisor ◽  
Submandibular Region ◽  
Submandibular Duct ◽  
Gland Duct ◽  
Wharton’S Duct

Introduction: The submandibular gland is located bilaterally in the submandibular triangle. The main submandibular duct or Wharton’s duct, runs with lingual nerve to open in the sublingual papilla at the side of frenulum of the tongue. The aim of this study was to demonstrate the unusual variations of accessory submandibular duct in comparison with main submandibular salivary gland duct. Material & Methods: Nineteen cadavers were dissected to study the submandibular salivary duct. Results: 15.7% incidence of variations were observed. We found that one submandibular region was having unusual path of accessory duct, it emerged from superficial part of the gland and crossed the superficial surface of mylohyoid muscle and bifurcated into two branches. These bifurcated branches of duct pierced the mylohyoid muscle to pass between mylohyoid and hyoglossus muscle. One branch of bifurcated accessory duct opened through papilla in the floor of the mouth behind the lower incisor tooth and second branch of the bifurcated duct anastomosed with the main duct (Wharton’s duct) to open in sublingual papilla. Wharton’s duct of this side followed its normal path to open in the sublingual papilla. Two specimens of submandibular region was observed with duplication of submandibular duct in each submandibular gland. One was main duct and second was accessory duct. Both ducts emerged separately from the deep part of submandibular gland and ended independently into sublingual papilla. Conclusion: Reporting of these variations are important for diagnostic imaging, anatomical teaching and to help surgeons while operating in this region.

scholarly journals The determination of specificity, sensitivity and accuracy of core needle biopsy in the diagnosis of parotid and submandibular salivary glands tumors

2019 ◽  
Vol 76 (9) ◽  
pp. 921-928
Author(s):  
Aleksandar Oroz ◽  
Zorana Bokun ◽  
Djordje Antonijevic ◽  
Jasna Jevdjic
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Tumor Tissue ◽  
Submandibular Salivary Gland ◽  
Histopathological Analysis ◽  
Core Needle ◽  
Parotid Salivary Gland ◽  
Submandibular Salivary Glands

Background/Aim. The diagnosis of tumors of salivary glands relies heavily on radiological examination and biopsy of pathological tissue. The aim of this study was to investigate the sensitivity, specificity and accuracy of core needle biopsy in diagnosis of tumors of parotid and submandibular glands. Methods. This study was designed as a crosssectional clinical trial performed between May 2008 and ?ay 2015 at the Department of Otorhinolaryngology and Maxillofacial Surgery, Clinical Center Zemun, Belgrade, Serbia. The examinations included 200 patients among which 100 were diagnosed with tumors of parotid salivary glands and 100 with tumors of submandibular salivary glands. The core needle biopsy was undertaken in all cases where tumor was smaller than 2 cm, far from blood vessels and far from the deep layer of parotid gland. The histopathological analysis was performed to identify histological type of the lesion. Upon performing the surgical procedure and consequently the tumor tissue extirpation, tissue samples obtained were investigated for the definitive diagnosis. Results. The sensitivity of the procedure was 90.9% for parotid salivary gland and 74% for submandibular salivary gland, the specificity was 95.9% for parotid salivary gland and 93% for submandibular salivary gland and the accuracy was 94.7% for parotid salivary gland and 87% for submandibular salivary gland. Based on the histopathological findings of the salivary glands obtained using core needle biopsy of the tumor tissue, it was possible to differentiate between malignant and benign lesions. Conclusion. Current investigation points to the advantages and efficiency of core needle biopsy in diagnosis of tumors of parotid and submandibular salivary glands.

Immunohistochemical characterization of superior cervical ganglion neurons supplying porcine parotid salivary gland

2011 ◽  
Vol 500 (1) ◽  
pp. 57-62 ◽  
Author(s):  
Joanna Wojtkiewicz ◽  
Judyta K. Juranek ◽  
Ireneusz Kowalski ◽  
Marek Bladowski ◽  
Jarosław Całka ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Superior Cervical Ganglion ◽  
Parotid Salivary Gland ◽  
Cervical Ganglion ◽  
Ganglion Neurons

Dual Sympathetic Input into Developing Salivary Glands

2019 ◽  
Vol 98 (10) ◽  
pp. 1122-1130 ◽  
Author(s):  
T.H.N. Teshima ◽  
A.S. Tucker ◽  
S.V. Lourenço
Keyword(s):  
Salivary Gland ◽  
Superior Cervical Ganglion ◽  
Time Course ◽  
Sympathetic Nerves ◽  
Branching Morphogenesis ◽  
Developmental Time ◽  
Explant Culture ◽  
Early Stages ◽  
Cervical Ganglion ◽  
Gland Development

Neuronal signaling is known to be required for salivary gland development, with parasympathetic nerves interacting with the surrounding tissues from early stages to maintain a progenitor cell population and control morphogenesis. In contrast, postganglionic sympathetic nerves arrive late in salivary gland development to perform a secretory function; however, no previous report has shown their role during development. Here, we show that a subset of neuronal cells within the parasympathetic submandibular ganglion (PSG) express the catecholaminergic marker tyrosine hydroxylase (TH) in developing murine and human submandibular glands. This sympathetic phenotype coincided with the expression of transcription factor Hand2 within the PSG from the bud stage (E12.5) of mouse embryonic salivary gland development. Hand2 was previously associated with the decision of neural crest cells to become sympathetic in other systems, suggesting a role in controlling neuronal fate in the salivary gland. The PSG therefore provides a population of TH-expressing neurons prior to the arrival of the postganglionic sympathetic axons from the superior cervical ganglion at E15.5. In culture, in the absence of nerves from the superior cervical ganglion, these PSG-derived TH neurons were clearly evident forming a network around the gland. Chemical ablation of dopamine receptors in explant culture with the neurotoxin 6-hydroxydopamine at early stages of gland development resulted in specific loss of the TH-positive neurons from the PSG, and subsequent branching was inhibited. Taken altogether, these results highlight for the first time the detailed developmental time course of TH-expressing neurons during murine salivary gland development and suggest a role for these neurons in branching morphogenesis.

Sialolithiasis in a residual Wharton's duct after excision of a submandibular salivary gland

2006 ◽  
Vol 121 (2) ◽  
pp. 182-185 ◽  
Author(s):  
M R Markiewicz ◽  
J E Margarone 3rd ◽  
J L Tapia ◽  
A Aguirre
Keyword(s):  
Salivary Gland ◽  
Submandibular Gland ◽  
Acute Infection ◽  
Surgical Techniques ◽  
Surgical Approaches ◽  
Submandibular Salivary Gland ◽  
Major Salivary Gland ◽  
Continuous Growth ◽  
Wharton’S Duct ◽  
Submandibular Gland Excision

Treatment of salivary stones includes both surgical and non-surgical techniques. Surgical approaches range from excision of the sialolith, for those near the duct orifice, to removal of the affected salivary gland and its associated duct, for stones near the hilum of the gland. We present a case of two sialoliths triggering an acute infection in a residual Wharton's duct, 12 years after the removal of the associated submandibular gland. Excision of the sialoliths and treatment of the infected duct via sialodochoplasty was successfully performed in this patient. If the Wharton's duct is not removed with the associated submandibular gland, the potential for infection and continuous growth of dormant calcifications exists. We also address the aetiology, pathogenesis, and management of patients with sialolithiasis in the absence of a major salivary gland.

scholarly journals An In Vitro Barrier Model of the Human Submandibular Salivary Gland Epithelium Based on a Single Cell Clone of Cell Line HTB-41: Establishment and Application for Biomarker Transport Studies

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 302
Author(s):  
Grace C. Lin ◽  
Merima Smajlhodzic ◽  
Anna-Maria Bandian ◽  
Heinz-Peter Friedl ◽  
Tamara Leitgeb ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Line ◽  
Submandibular Gland ◽  
Immunofluorescent Staining ◽  
Epithelial Barrier ◽  
Submandibular Salivary Gland ◽  
Iron Storage ◽  
Model Based ◽  
Transport Studies

The blood–saliva barrier (BSB) consists of the sum of the epithelial cell layers of the oral mucosa and salivary glands. In vitro models of the BSB are inevitable to investigate and understand the transport of salivary biomarkers from blood to saliva. Up to now, standardized, cell line-based models of the epithelium of the submandibular salivary gland are still missing for this purpose. Therefore, we established epithelial barrier models of the submandibular gland derived from human cell line HTB-41 (A-253). Single clone isolation resulted in five different clones (B2, B4, B9, D3, and F11). Clones were compared to the parental cell line HTB-41 using measurements of the transepithelial electrical resistance (TEER), paracellular marker permeability assays and analysis of marker expression for acinar, ductal, and myoepithelial cells. Two clones (B9, D3) were characterized to be of acinar origin, one clone (F11) to be of myoepithelial origin and one isolation (B4) derived from two cells, to be presumably a mixture of acinar and ductal origin. Clone B2, presumably of ductal origin, showed a significantly higher paracellular barrier compared to other clones and parental HTB-41. The distinct molecular identity of clone B2 was confirmed by immunofluorescent staining, qPCR, and flow cytometry. Experiments with ferritin, a biomarker for iron storage, demonstrated the applicability of the selected model based on clone B2 for transport studies. In conclusion, five different clones originating from the submandibular gland cell line HTB-41 were successfully characterized and established as epithelial barrier models. Studies with the model based on the tightest clone B2 confirmed its suitability for transport studies in biomarker research.

Hypoglossal schwannoma in the submandibular region

2021 ◽  
Vol 14 (5) ◽  
pp. e242225
Author(s):  
Aparna Das ◽  
Sivaraman Ganesan ◽  
Kalaiarasi Raja ◽  
Arun Alexander
Keyword(s):  
Salivary Gland ◽  
Submandibular Gland ◽  
Hypoglossal Nerve ◽  
Malignant Lesion ◽  
Submandibular Salivary Gland ◽  
Submandibular Region ◽  
Imaging Characteristics ◽  
Contrast Enhanced Ct ◽  
The Right ◽  
Hypoglossal Schwannoma

Hypoglossal nerve schwannomas originating extracranially and mimicking a submandibular salivary gland tumour are extremely rare. A 55-year-old woman presented with a painless, gradually increasing swelling in the right submandibular region for the past 1 year. Fine-needle aspiration cytology and contrast-enhanced CT of the swelling showed features of submandibular gland malignant lesion. Intraoperatively, the right submandibular gland with a hypoglossal nerve swelling was noticed. Right submandibular gland along with the hypoglossal swelling were excised with adequate margins. However, the postoperative histopathology was reported as hypoglossal nerve schwannoma and a normal salivary gland. Accurate preoperative diagnosis of hypoglossal schwannomas may be challenging. A high level of suspicion must be sought for in cases with unusual clinical presentations and imaging characteristics. Herein, we report a rare presentation of submandibular hypoglossal schwannoma along with its clinical features and its management.

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