Metabolism of free fatty acids by myocardium and kidney

1964 ◽  
Vol 206 (1) ◽  
pp. 153-158 ◽  
Author(s):  
Martin Gold ◽  
John J. Spitzer
Keyword(s):  
Fatty Acids ◽  
Palmitic Acid ◽  
Free Fatty Acids ◽  
Coronary Sinus ◽  
Renal Vein ◽  
Specific Activity ◽  
Long Chain Fatty Acids ◽  
Significant Production ◽  
Long Chain ◽  
Chain Fatty Acids

The myocardial and renal removal and oxidation of plasma free fatty acids (FFA) were studied in dogs receiving an infusion of I-C14-palmitate, oleate, linoleate, or octanoate. The myocardium extracted about 40% of the total arterial FFA, and some was oxidized to CO2. Blood C14O2 was consistently higher in the coronary sinus than in the artery. The specific activity of the coronary sinus C14O2 was higher than that of the arterial C14O2 in dogs infused with long-chain fatty acids. The specific activity of arterial C14O2 was higher than that of the coronary sinus C14O2 when octanoate was infused. There were no differences observed in FFA extraction and C14O2 production among the different groups of animals receiving the various long-chain fatty acids. In gas chromatographic studies palmitic acid was the only FFA with a consistent net removal by the kidney. Approximately 9% of the arterial radiopalmitate was removed by this organ in dogs receiving infusions of palmitic acid-1-C14. Simultaneously, C14O2 was produced by the kidney. A consistent removal of oleate-1-C14 or a significant production of C14O2 was not found. Infusion of octanoate-1-C14 led to a marked release of C14O2 by the kidney, with greatly increased CO2 specific activity in the renal vein.

scholarly journals Dietary and Endogenous Long-Chain Fatty Acids in the Intestine of Sheep, with an Appendix on Their Estimation in Feeds, Bile, and Faeces

1969 ◽  
Vol 22 (4) ◽  
pp. 1015 ◽  
Author(s):  
TJ Heath ◽  
L N Hill
Keyword(s):  
Fatty Acids ◽  
Bile Duct ◽  
Palmitic Acid ◽  
Thoracic Duct ◽  
Quantitative Information ◽  
Significant Alteration ◽  
Long Chain Fatty Acids ◽  
Gain Access ◽  
Long Chain ◽  
Chain Fatty Acids

Normal sheep and sheep with fistulae of the bile duct or the thoracic duct were used to provide quantitative information on the movement of fatty acids into and out of the intestine. The operation used to gain access to the thoracic duct did not cause any significant alteration in the absorption of either [14C]tripalmitin injected into the rumen or [14C]palmitic acid injected into the duodenum. Normal sheep absorbed the major fatty acids oleic (92'1�1'3%), palmitic (87�3�5�0%), and stearic acids (93' 3� 1� 4%) with almost equal efficiency, and the absorption of labelled tri-palmitin injected into the rumen did not alter as the intake of fatty acids increased from 12g/day (90�1�2�3%) to 44g/day (90�1�1�3%).

Free fatty acid metabolism by skeletal muscle

1964 ◽  
Vol 206 (1) ◽  
pp. 159-164 ◽  
Author(s):  
John J. Spitzer ◽  
Martin Gold
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Specific Activity ◽  
Venous Blood ◽  
Long Chain Fatty Acids ◽  
Carbon 14 ◽  
Arterial Blood ◽  
Free Fatty Acid Metabolism ◽  
Long Chain ◽  
Chain Fatty Acids

Removal and oxidation of free fatty acids (FFA) were studied by the electrically stimulated skeletal muscle in dogs receiving an infusion of I-C14-palmitate, oleate, linoleate, or octanoate. Resting skeletal muscle removed about 43% of the arterial FFA. The A-V difference was directly proportional to the arterial FFA level. During electrical stimulation the removal increased due to the increased blood flow while the extraction ratio decreased. A portion of the infused carbon 14 appeared in the venous blood as C14O2 in all animals receiving either long-chain fatty acids or octanoate. The specific activity of C14O2 in the venous blood became higher than that in the arterial blood during stimulation when long-chain fatty acids were infused, but did not undergo such changes when octanoate was infused. No differences were observed between the different groups of animals receiving the various long-chain fatty acids. It is postulated that only a fraction of the removed FFA is immediately oxidized, while a portion is stored and oxidized at a later date.

scholarly journals Long-chain fatty acids of Sporothrix (Sporotrichum) schenckii

1976 ◽  
Vol 3 (6) ◽  
pp. 635-636
Author(s):  
R J Stretton ◽  
R K Dart
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Palmitic Acid ◽  
Acid Content ◽  
Fatty Acid Content ◽  
Sporothrix Schenckii ◽  
Major Fatty Acid ◽  
Long Chain Fatty Acids ◽  
Long Chain ◽  
Chain Fatty Acids

A number of strains purporting to belong to the species Sporothrix schenckii were examined for their fatty acid content. The majority of the strains were isolated from cases of sporotrichosis. Two strains were reputedly saprophytic. In all cases except the two saprophytic ones the major fatty acid was a C18 diene. Considerable amounts of palmitic acid and C18 monoene were found in all strains.

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