Binding of bilirubin and long-chain fatty acids to human serum albumin with general remarks on displacement of firmly bound ligands

1977 ◽  
Vol 37 (3) ◽  
pp. 257-266 ◽  
Author(s):  
R. Brodersen ◽  
L. Funding
Keyword(s):  
Fatty Acids ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Long Chain Fatty Acids ◽  
Long Chain ◽  
Chain Fatty Acids

scholarly journals Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0180404 ◽  
Author(s):  
Keishi Yamasaki ◽  
Saya Hyodo ◽  
Kazuaki Taguchi ◽  
Koji Nishi ◽  
Noriyuki Yamaotsu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Binding Sites ◽  
Drug Binding ◽  
Long Chain Fatty Acids ◽  
Drug Binding Sites ◽  
Long Chain ◽  
Chain Fatty Acids

scholarly journals Conformational changes in human serum albumin studied by fluorescence and absorption spectroscopy. Distance measurements as a function of pH and fatty acids

1989 ◽  
Vol 258 (1) ◽  
pp. 199-204 ◽  
Author(s):  
B Honoré ◽  
A O Pedersen
Keyword(s):  
Fatty Acids ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Conformational Changes ◽  
Saturated Fatty Acids ◽  
Distance Measurements ◽  
Low Concentrations ◽  
Long Chain ◽  
Chain Fatty Acids

pH- and fatty acid-induced conformational changes in human serum albumin were investigated by fluorescence-energy transfer, determining the distance between Trp-214 and bound bilirubin at 25 degrees C. This distance changes significantly with the pH, being 2.52 +/- 0.01 nm at pH 6, 2.31 +/- 0.04 nm at pH 9, 2.13 +/- 0.07 nm at pH 11.0 and 2.77 nm at pH 11.9. The influence of different fatty acids on the distance was also determined. At pH 7.4 medium-chain fatty acids seem to increase this distance, whereas long-chain fatty acids, at low concentrations, decrease the distance between the two chromophores. The contraction of the protein carrying long-chain saturated fatty acids is even more pronounced at pH 9.

scholarly journals Binding of long-chain fatty acids to bovine serum albumin

1969 ◽  
Vol 10 (1) ◽  
pp. 56-67
Author(s):  
Arthur A. Spector ◽  
Kathryn John ◽  
John E. Fletcher
Keyword(s):  
Fatty Acids ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Long Chain Fatty Acids ◽  
Long Chain ◽  
Chain Fatty Acids

scholarly journals Binding of long-chain fatty acids to serum albumin in healthy humans Relationship to obesity

1991 ◽  
Vol 197 (2) ◽  
pp. 461-465 ◽  
Author(s):  
Rolf BRODERSEN ◽  
Henrik VORUM ◽  
Niels KRUKOW ◽  
Anders Overgaard PEDERSEN
Keyword(s):  
Fatty Acids ◽  
Serum Albumin ◽  
Long Chain Fatty Acids ◽  
Healthy Humans ◽  
Long Chain ◽  
Chain Fatty Acids
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