Amino acid imbalance protein intake, and changes in rat brain and plasma amino acids

1972 ◽  
Vol 223 (6) ◽  
pp. 1497-1497
Author(s):  
Y. Peng ◽  
J. K. Tews ◽  
A. E. Harper
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Rat Brain ◽  
Protein Intake ◽  
Plasma Amino Acids ◽  
Amino Acid Imbalance

Page 314: Y. Peng, J. K. Tews, and A. E. Harper. "Amino acid imbalance protein intake, and changes in rat brain and plasma amino acids." Page 317, Fig. 5: the top section should carry the heading "HISTIDINE IMBALANCE (liver)."

Food Intake Regulation: Amino Acid Toxicity and Changes in Rat Brain and Plasma Amino Acids

1973 ◽  
Vol 103 (4) ◽  
pp. 608-617 ◽  
Author(s):  
Y. Peng ◽  
J. Gubin ◽  
A. E. Harper ◽  
M. G. Vavich ◽  
A. R. Kemmerer
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Food Intake ◽  
Rat Brain ◽  
Plasma Amino Acids ◽  
Food Intake Regulation ◽  
Acid Toxicity ◽  
Intake Regulation

CIRCADIAN PERIODICITY OF BLOOD AMINO ACIDS IN THE NEONATE

PEDIATRICS ◽  
1970 ◽  
Vol 45 (5) ◽  
pp. 782-791
Author(s):  
Ralph D. Feigin ◽  
Morey W. Haymond
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Detailed Analysis ◽  
Normal Values ◽  
Time Of Day ◽  
Plasma Amino Acids ◽  
Older Children ◽  
Total Blood ◽  
Term Infants ◽  
Plasma Tyrosine

Blood amino acids were obtained every 4 hours for 24 hours from 46 full-term infants who were between 1 hour and 120 hours of age when first sampled. Blood was also obtained at 0400 and 1200 hours on the same day from 10 additional infants, aged 48 to 72 hours at the time of study, for more detailed analysis of individual blood amino acids. Periodicity of total blood amino acids was demonstrated as early as the first day of life in some infants. This blood amino acid rhythmicity was similar but not identical to that previously observed in adults and older children. Concentrations of blood amino acids were minimal at 0400 hours and peaked between 1200 and 2000 hours. Periodicity of individual blood amino acids was similar to that for total blood amino acids but much less consistent. The presence of periodicity for plasma tyrosine was demonstrable even in two patients with neonatal tyrosinemia. Since plasma amino acids vary normally as a function of time, "normal values" must be standardized for time of day.

Effect of Amino Acid Imbalance on Plasma and Tissue Free Amino Acids in the Rat

1968 ◽  
Vol 96 (3) ◽  
pp. 303-318 ◽  
Author(s):  
P. M.-B. Leung ◽  
Q. R. Rogers ◽  
A. E. Harper
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Free Amino Acids ◽  
Free Amino ◽  
Amino Acid Imbalance

scholarly journals The Amino Acid Need for Milk Synthesis Is Defined by the Maximal Uptake of Plasma Amino Acids by Porcine Mammary Glands

2004 ◽  
Vol 134 (9) ◽  
pp. 2182-2190 ◽  
Author(s):  
Xinfu Guan ◽  
Brian J. Bequette ◽  
Pao K. Ku ◽  
Robert J. Tempelman ◽  
Nathalie L. Trottier
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Mammary Glands ◽  
Plasma Amino Acids

High Protein Intake during Continuous Hemodiafiltration: Impact on Amino Acids and Nitrogen Balance

2002 ◽  
Vol 25 (4) ◽  
pp. 261-268 ◽  
Author(s):  
R. Bellomo ◽  
H. K. Tan ◽  
S. Bhonagiri ◽  
I. Gopal ◽  
J. Seacombe ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Nitrogen Balance ◽  
Protein Intake ◽  
Protein Supplementation ◽  
High Protein ◽  
Total Serum ◽  
Amino Acid Supplementation ◽  
Continuous Hemodiafiltration ◽  
High Protein Intake

Aims To study the effect of combined continuous veno-venous hemodiafiltration (CVVHDF) and high (2.5 g/kg/day) parenteral amino acid supplementation on nitrogen balance, amino acid losses and azotemic control in a cohort of patients with severe acute renal failure (ARF). Methods We administered 2.5 grams/kg/day of amino acids intravenously to seven critically ill patients with ARF. We obtained paired blood and ultrafiltrate (UF) samples (n=20) and calculated amino acid clearances and losses, nitrogen balance, protein catabolic rate and total nitrogen losses. Results The median total serum amino acid concentration was high at 5.2 mmol/L with particularly high concentrations of ornithine, lysine, and phenylalanine, but a low level of histidine. The median overall amino acid clearance was 18.6 ml/min (range: 12 to 29 ml/min). UF losses as percentage of administered dose were high for tyrosine (53.6 %) but low for methionine (3.0 %) and arginine (2.3 %). A positive nitrogen balance was achieved in 7 (35%) of the 20 study days with an overall median nitrogen balance of -1.8 g/day. Urea levels were maintained at a median of 26.6 mmol/L. Conclusions High protein intake increases the serum concentrations of most amino acids. Such protein supplementation, when coupled with CVVHDF, achieves a slightly negative overall nitrogen balance in extremely catabolic patients while still allowing adequate azotemic control.

Source and function of urinary ammonia in the alligator

1959 ◽  
Vol 197 (4) ◽  
pp. 873-879 ◽  
Author(s):  
Roland A. Coulson ◽  
Thomas Hernandez
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Acid Level ◽  
Amino Acid Level ◽  
Plasma Amino Acid ◽  
Plasma Amino Acids ◽  
Renal Reabsorption ◽  
And Function ◽  
Phosphate Solutions

The rate of renal deamination of 18 amino acids was determined by injecting them into alligators and measuring the ammonia excreted. Not only did glycine, alanine, glutamine and leucine account for nearly half of the plasma amino acids, they were also deaminated more rapidly than any of the others. In view of this it was concluded that these four amino acids are the natural precursors of urinary NH3 in the alligator. Increased NH3 and CO2 excretion following glycine injections resulted in increased renal reabsorption of Na and Cl when NaCl was injected and increased Na reabsorption when NaHCO3 or Na phosphate solutions were injected. The fact that excess NH4HCO3 excretion enhances salt reabsorption independent of plasma pH makes it probable that the excretion of N is the chief function of the ammonia mechanism and that salt conservation is incidental. Insulin decreased the plasma amino acid level and drastically reduced the NH3 excretion. With the decrease in ammonia, NaCl and NaHCO3 were excreted in increased amounts.

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