scholarly journals MAFbx, MuRF1, and the stress-activated protein kinases are upregulated in muscle cells during total knee arthroplasty

2012 ◽  
Vol 303 (4) ◽  
pp. R376-R386 ◽  
Author(s):  
Ashley N. Bailey ◽  
Austin D. Hocker ◽  
Benjamin R. Vermillion ◽  
Keith Smolkowski ◽  
Steven N. Shah ◽  
...  
Keyword(s):  
Older Adults ◽  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Muscle Protein ◽  
Vastus Lateralis ◽  
Cost Effective ◽  
Mrna Levels ◽  
Tourniquet Time ◽  
Total Knee ◽  
Expanding Population

Total knee arthroplasty (TKA) is the most common and a cost-effective surgical remediation for older adults with long-standing osteoarthritis. In parallel with the expanding population of older adults, the number of TKAs performed annually is projected to be 3.48 million by 2030. During this surgery, a tourniquet is used to stop blood flow to the operative leg. However, the molecular pathways that are affected by tourniquet use during TKA continue to be elucidated. We hypothesized that components of the catabolic FoxO3a (i.e., MuRF1, MAFbx, and Bnip3) pathway, as well as the cellular stress pathways [i.e., stress-activated protein kinase (SAPK)/JNK and MAPKs], are upregulated during TKA. The purpose of this study was to measure changes in transcripts and proteins involved in muscle cell catabolic and stress-activated pathways. We obtained muscle biopsies from subjects, 70 ± 1.3 yr, during TKA, from the vastus lateralis at baseline (before tourniquet inflation), during maximal ischemia (just before tourniquet release), and during reperfusion. Total tourniquet time was 43 ± 2 min and reperfusion time was 16 ± 1. Significant increases in FoxO3a downstream targets, MAFbx and MuRF1, were present for mRNA levels during ischemia (MAFbx, P = 0.04; MuRF1, P = 0.04), and protein expression during ischemia (MAFbx, P = 0.002; MuRF1, P = 0.001) and reperfusion (MuRF1, P = 0.002). Additionally, stress-activated JNK gene expression ( P = 0.01) and protein were elevated during ischemia ( P = 0.001). The results of this study support our hypothesis that protein degradation pathways are stimulated during TKA. Muscle protein catabolism is likely to play a role in the rapid loss of muscle volume measured within 2 wk of this surgery.

scholarly journals Slight femoral under-correction versus neutral alignment in total knee arthroplasty with preoperative varus knees: a comparative study

Arthroplasty ◽  
2022 ◽  
Vol 4 (1) ◽  
Author(s):  
Kai Lei ◽  
Li-Ming Liu ◽  
Peng-Fei Yang ◽  
Ran Xiong ◽  
De-Jie Fu ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Operative Time ◽  
Length Of Hospital Stay ◽  
Clinical Results ◽  
Patient Reported Outcome Measures ◽  
Tourniquet Time ◽  
Patient Reported ◽  
Total Knee ◽  
Neutral Alignment

Abstract Background This study aimed to compare the short-term clinical results of slight femoral under-correction with neutral alignment in patients with preoperative varus knees who underwent total knee arthroplasty. Methods The medical records and imaging data were retrospectively collected from patients who had undergone total knee arthroplasty in our hospital from January 2016 to June 2019. All patients had varus knees preoperatively. Upon 1:1 propensity score matching, 256 patients (256 knees) were chosen and divided into a neutral alignment group (n=128) and an under-correction group (n=128). The patients in the neutral group were treated with the neutral alignment. In the under-correction group, the femoral mechanical axis had a 2° under-correction. The operative time, tourniquet time and the length of hospital stay in the two groups were recorded. The postoperative hip-knee-ankle angle, frontal femoral component angle and frontal tibial component angle were measured. Patient-reported outcome measures were also compared. Results The operative time, tourniquet time and the length of hospital stay in the under-correction group were significantly shorter than the neutral alignment group (P<0.05). At the 2-year follow-up, the under-correction group had a larger varus alignment (P<0.05) and a larger frontal femoral component angle (P<0.05), and the frontal tibial component angles of the two groups were comparable. Compared with the neutral alignment group, the slight femoral under-correction group had significantly better patient-reported outcome measures scores (P<0.05). Conclusion For varus knees treated with total knee arthroplasty, alignment with a slight femoral under-correction has advantages over the neutral alignment in terms of the shorter operative time and better short-term clinical results. Level of evidence III

scholarly journals Comparison of Alignment and Prosthesis Positioning Accuracy Between Robotics and Personalized 3D Preoperative Planning in Total Knee Arthroplasty

2021 ◽  
Author(s):  
Kai Lei ◽  
LiMing Liu ◽  
PengFei Yang ◽  
Ran Xiong ◽  
Liu Yang ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Tibial Component ◽  
Preoperative Planning ◽  
Operation Time ◽  
Consecutive Series ◽  
Clinical Trial Registry ◽  
Tourniquet Time ◽  
Positioning Accuracy ◽  
Total Knee

Abstract Purpose: Lower limb alignment is crucial in total knee arthroplasty (TKA). Previous studies have shown that robotics and personalized three-dimensional (3D) preoperative planning could improve postoperative alignment accuracy compared with conventional TKA, but comparison between the above two techniques has never been reported. The purpose of this study was to compare the alignment and prosthesis positioning accuracy between robotics and personalized 3D preoperative planning in TKA.Methods: A consecutive series of patients who received TKA in our Center from September 2020 to January 2021 were enrolled. After 1:2 matching, 52 and 104 patients were eventually included in robotics group and personalized 3D preoperative planning group, respectively. Multiple postoperative alignment variables, operation time, tourniquet time, length of hospital stay, hemoglobin (Hb) decrease at 1 and 3 days after operation were recorded and compared.Results: Compared with personalized 3D preoperative planning, robotics had significantly lower frontal tibial component (FTC) angle absolute deviation (P<0.001) and less FTC outliers (P<0.05). The postoperative hip-knee-ankle (HKA) angle and frontal femoral component (FFC) angle were different between two groups, while the absolute deviations were similar. Hb decreases of robotics were significantly lower than those of personalized 3D preoperative planning (P<0.001), while the operation time and tourniquet time were longer (P<0.001).Conclusion: Compared with personalized 3D preoperative planning, robotics has more accurate tibial component coronal alignment and less postoperative Hb decrease, while the operation time is significantly longer.Trial registration: The Chinese Clinical Trial Registry, ChiCTR2000036235. Registered 22 August 2020, http://www.chictr.org.cn/showproj.aspx?proj=59300

scholarly journals Outpatient total knee arthroplasty: is it worth considering?

2020 ◽  
Vol 5 (3) ◽  
pp. 172-179
Author(s):  
E. Carlos Rodríguez-Merchán
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Discharge Planning ◽  
Young Patients ◽  
Cost Effective ◽  
Medical Outcomes ◽  
Vein Thrombosis ◽  
Cost Effective Treatment ◽  
Total Knee ◽  
Deep Vein

Some authors have reported that outpatient total knee arthroplasty (TKA) is a successful, safe and cost-effective treatment in the management of advanced osteoarthritis. The success obtained has been attributed to the coordination of the multidisciplinary team, standardized perioperative protocols, optimal hospital discharge planning and careful selection of patients. One study has demonstrated a higher risk of perioperative surgical and medical outcomes in outpatient TKA than inpatient TKA, including component failure, surgical site infection, knee stiffness and deep vein thrombosis. There remains a lack of universal criteria for patient selection. Outpatient TKA has thus far been performed in relatively young patients with few comorbidities. It is not yet clear whether outpatient TKA is worth considering, except in very exceptional cases (young patients without associated comorbidities). Outpatient TKA should not be generally recommended at the present time. Cite this article: EFORT Open Rev 2020;5:172-179. DOI: 10.1302/2058-5241.5.180101

scholarly journals The efficacy of pre-emptive analgesia on pain management in total knee arthroplasty: a mini-review

Arthroplasty ◽  
2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Jianda Xu ◽  
Huan Li ◽  
Chong Zheng ◽  
Bin Wang ◽  
Pengfei Shen ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Pain Management ◽  
Postoperative Pain ◽  
Knee Arthroplasty ◽  
Physiological Mechanism ◽  
Cost Effective ◽  
Postoperative Pain Management ◽  
Multimodal Analgesia ◽  
Total Knee ◽  
End Stage

Abstract Total knee arthroplasty (TKA) is considered a cost-effective and efficacious treatment for patients with end-stage knee arthritis. Meanwhile, TKA has been regarded as one of the most painful orthopaedic surgeries. Pain control after TKA remains a challenging task. Many analgesic innovations are used to reduce the level of pain, but none has been proven to be the optimum choice till now. Multimodal analgesia incorporates the use of analgesic adjuncts with different mechanisms of action to enhance postoperative pain management. This approach is a preferable choice in relieving postoperative pain with minimum side effects. This paper aims to review pre-emptive analgesia for pain management in TKA. We reviewed the application of pre-emptive analgesia, its physiological mechanism, and the techniques.

scholarly journals Robot-Assisted Navigation versus Computer-Assisted Navigation in Primary Total Knee Arthroplasty: Efficiency and Accuracy

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Tanner C. Clark ◽  
Frank H. Schmidt
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Primary Total Knee Arthroplasty ◽  
Secondary Outcome ◽  
Computer Assisted ◽  
Robot Assisted ◽  
Tourniquet Time ◽  
Assisted Navigation ◽  
Total Knee ◽  
Primary Total Knee

Background. Since the introduction of robot-assisted navigation in primary total knee arthroplasty (TKA), there has been little research conducted examining the efficiency and accuracy of the system compared to computer-assisted navigation systems. Objective. To compare the efficiency and accuracy of Praxim robot-assisted navigation (RAN) and Stryker computer-assisted navigation (CAN) in primary TKA. Methods. This was a retrospective study consisting of 52 patients who underwent primary TKA utilizing RAN and 29 patients utilizing CAN. The primary outcome measure was navigation time. Secondary outcome measures included intraoperative final mechanical axis alignment, intraoperative robot-assisted bone cut accuracy, tourniquet time, and hospitalization length. Results. RAN navigation times were, on average, 9.0 minutes shorter compared to CAN after adjustment. The average absolute intraoperative malalignment was 0.5° less in the RAN procedures compared to the CAN procedures after adjustment. Patients in the RAN group tended to be discharged 0.6 days earlier compared to patients in the CAN group after adjustment. Conclusions. Among patients undergoing TKA, there was decreased navigation time, decreased final malalignment, and decreased hospitalization length associated with the use of RAN when compared to CAN independent of age, BMI, and pre-replacement alignment.

A Pilot Study Evaluating Presurgery Neuroanatomical Biomarkers for Postoperative Cognitive Decline After Total Knee Arthroplasty in Older Adults

2014 ◽  
Vol 58 (4) ◽  
pp. 173-174
Author(s):  
Catherine C. Price ◽  
Jared J. Tanner ◽  
Ilona Schmalfuss ◽  
Cynthia Wilson Garvan ◽  
Peter Gearen ◽  
...  
Keyword(s):  
Older Adults ◽  
Total Knee Arthroplasty ◽  
Pilot Study ◽  
Cognitive Decline ◽  
Knee Arthroplasty ◽  
Postoperative Cognitive Decline ◽  
Total Knee

Process Improvement Project Using Tranexamic Acid Is Cost-Effective in Reducing Blood Loss and Transfusions After Total Hip and Total Knee Arthroplasty

2017 ◽  
Vol 32 (8) ◽  
pp. 2375-2380 ◽  
Author(s):  
Harry A. Demos ◽  
Zilan X. Lin ◽  
William R. Barfield ◽  
Sylvia H. Wilson ◽  
Dawn C. Robertson ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Process Improvement ◽  
Knee Arthroplasty ◽  
Cost Effective ◽  
Improvement Project ◽  
Total Hip ◽  
Total Knee

Muscle Force Steadiness in Older Adults Before and After Total Knee Arthroplasty

2014 ◽  
Vol 29 (6) ◽  
pp. 1143-1148 ◽  
Author(s):  
Jessica W. Smith ◽  
Robin L. Marcus ◽  
Christopher L. Peters ◽  
Christopher E. Pelt ◽  
Brian L. Tracy ◽  
...  
Keyword(s):  
Older Adults ◽  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Muscle Force ◽  
Force Steadiness ◽  
Before And After ◽  
Total Knee

scholarly journals Efficiency and Blood Loss of Various Spacer and Intramedullary Dowel Constructs in Two-Stage Treatment of Total Knee Arthroplasty

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Hanna House, BS ◽  
Mary Ziemba-Davis, BA ◽  
Michael Meneghini, MD
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Knee Arthroplasty ◽  
Operative Time ◽  
Operating Time ◽  
Treatment Protocol ◽  
Two Stage ◽  
Tourniquet Time ◽  
Infected Total Knee Arthroplasty ◽  
Total Knee

Background and Hypothesis: Treatment for infected total knee arthroplasty (TKA) employs antibiotic-eluding articulating or static spacers, with or without intramedullary (IM) dowels between implant resection and reimplantation. While it is unknown which spacer type is more efficient intra-operatively, IM dowels require additional time for fabrication. Surgical efficiency is critical to minimizing anesthesia time and blood loss, especially in complex surgeries with compromised hosts. We quantified operative time and postoperative intra-articular blood loss based on spacer type and the use of IM dowels. Project Methods: 103 consecutive infected TKAs treated from 2010-2019 were retrospectively reviewed. Outcome variables included operative time and intraarticular drain rate. Covariates included sex; age, BMI; ASA-PS classification; surgeon; McPherson infection classification; tourniquet time; tranexamic acid (TXA) use; intrathecal anesthesia, length of stay, and blood transfusion. Multivariate analyses were used. Results: The sample was 52% female with average age of 66±9 years and average BMI of 36±9 kg/m2. Articulating spacers without dowels (ASwoD), articulating spacers with dowels (ASwD), and static spacers with dowels were used in 57.3%, 21.4%, and 21.4% of knees, respectively. Longer mean operating time was observed when static spacers with dowels were used at resection (162 vs.130 ASwoD/140 ASwD minutes; p=0.001) and reimplantation (187 vs. 149 ASwoD/148 ASwD minutes; p=0.017). At reimplantation, drain rate was highest when articulating spacers with dowels were used (37 vs. 20/26 mL/hr), but not when TXA was used (p=0.002). Conclusion and Potential Impact: Articulating and static spacers provide equivalent infection eradication, and the necessity of IM dowels has not been thoroughly studied. In light of this equivalency, it is important to understand other costs associated with spacer types and IM dowels. Our observations that spacer/dowel constructs affect time under anesthesia and blood loss may contribute to the efficiency and safety of the two-stage treatment protocol.

A Simple Goniometer for Use Intra-Operatively in Total Knee Arthroplasty

2010 ◽  
Author(s):  
Kate D. Liddle ◽  
Jennifer Peter ◽  
Jovauna M. Currey ◽  
Jenni M. Buckley ◽  
William A. McGann
Keyword(s):  
Total Knee Arthroplasty ◽  
Range Of Motion ◽  
Knee Arthroplasty ◽  
Computer Assisted Surgery ◽  
Cost Effective ◽  
Knee Extension ◽  
Computer Assisted ◽  
Navigation Systems ◽  
Important Indicator ◽  
Total Knee

Intra-operative range of motion (ROM) assessment can be challenging during total knee arthroplasty (TKA) surgery. Measurement accuracy is often compromised by patient draping and anatomy, particularly when assessing knee extension. Accurate ROM assessment is important, as ROM after total knee arthroplasty is an important indicator of clinical outcome. Computer assisted surgery has been shown to accurately determine intra-operative range of motion; however, navigation systems are costly and not readily available to many surgeons. We have developed a simple, cost-effective intraoperative device to precisely measure knee flexion and extension that is efficient and easy to use.

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