Association of overactive bladder and stress urinary incontinence in rats with pudendal nerve ligation injury

2008 ◽  
Vol 294 (5) ◽  
pp. R1510-R1516 ◽  
Author(s):  
Akira Furuta ◽  
Masafumi Kita ◽  
Yasuyuki Suzuki ◽  
Shin Egawa ◽  
Michael B. Chancellor ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Overactive Bladder ◽  
Pudendal Nerve ◽  
Bladder Function ◽  
Urinary Continence ◽  
Detrusor Muscle ◽  
Pathophysiological Mechanism ◽  
Afferent Pathways ◽  
Contractile Responses

Approximately one-third of patients with stress urinary incontinence (SUI) also suffer from urgency incontinence, which is one of the major symptoms of overactive bladder (OAB) syndrome. Pudendal nerve injury has been recognized as a possible cause for both SUI and OAB. Therefore, we investigated the effects of pudendal nerve ligation (PNL) on bladder function and urinary continence in female Sprague-Dawley rats. Conscious cystometry with or without capsaicin pretreatment (125 mg/kg sc), leak point pressures (LPPs), contractile responses of bladder muscle strips to carbachol or phenylephrine, and levels of nerve growth factor (NGF) protein and mRNA in the bladder were compared in sham and PNL rats 4 wk after the injury. Urinary frequency detected by a reduction in intercontraction intervals and voided volume was observed in PNL rats compared with sham rats, but it was not seen in PNL rats with capsaicin pretreatment that desensitizes C-fiber-afferent pathways. LPPs in PNL rats were significantly decreased compared with sham rats. The contractile responses of detrusor muscle strips to phenylephrine, but not to carbachol, were significantly increased in PNL rats. The levels of NGF protein and mRNA in the bladder of PNL rats were significantly increased compared with sham rats. These results suggest that pudendal nerve neuropathy induced by PNL may be one of the potential risk factors for OAB, as well as SUI. Somato-visceral cross sensitization between somatic (pudendal) and visceral (bladder) sensory pathways that increases NGF expression and α1-adrenoceptor-mediated contractility in the bladder may be involved in this pathophysiological mechanism.

Lower urinary tract conditions

2020 ◽  
pp. 27-56
Author(s):  
Helen Jefferis ◽  
Natalia Price
Keyword(s):  
Risk Factors ◽  
Urinary Incontinence ◽  
Urinary Tract ◽  
Stress Urinary Incontinence ◽  
Lower Urinary Tract ◽  
Management Strategies ◽  
Bladder Function ◽  
Urinary Continence ◽  
Overactive Bladder Syndrome ◽  
Lower Urinary

This chapter covers conditions affecting the lower urinary tract. It begins with an overview and management strategies of overactive bladder syndrome, including both conservative and pharmacological methods. Stress urinary incontinence (SUI) is covered in detail, from an overview and risk factors, to conservative, surgical, and other interventions. The controversy surrounding synthetic mid-urethral slings is highlighted. Other types of urinary continence are defined, alongside voiding dysfunction. Finally, drugs that can affect bladder function are listed.

scholarly journals Effect of Preoperative Urodynamic Study on Urinary Outcomes after Transobturator Sling

2021 ◽  
Author(s):  
Pedro Rincon Cintra da Cruz ◽  
Aderivaldo Cabral Dias Filho ◽  
Gabriel Nardi Furtado ◽  
Rhaniellen Silva Ferreira ◽  
Ceres Nunes Resende
Keyword(s):  
Logistic Regression ◽  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Propensity Score ◽  
Urinary Continence ◽  
Urodynamic Study ◽  
Transobturator Sling ◽  
Continence Status ◽  
And Performance

Abstract Objective To evaluate whether performing preoperative urodynamic study influences postoperative urinary symptoms of women with stress urinary incontinence that underwent transobturator sling. Methods Retrospective analysis of patients treated for stress urinary incontinence by transobturator sling from August 2011 to October 2018. Predictor variables included preoperative urodynamic study, age, incontinence severity, body mass index, preoperative storage symptoms and previous anti-urinary incontinence procedure. Outcome variables were postoperative subjective continence status, storage symptoms and complications. Logistic regression after propensity score was employed to compare outcomes between patients who underwent or not pre-operative urodynamic study. Results The present study included 88 patients with an average follow-up of 269 days. Most patients (n = 52; 59.1%) described storage symptoms other than stress urinary incontinence, and 38 patients (43.2%) underwent preoperative urodynamic studies. Logistic regression after propensity score did not reveal an association between urinary continence outcomes and performance of preoperative urodynamic study (odds ratio 0.57; confidence interval [CI]: 0.11–2.49). Among women that did not undergo urodynamic study, there was a subjective improvement in urinary incontinence in 92% of the cases versus 87% in those that underwent urodynamic study (p = 0.461). Furthermore, postoperative storage symptoms were similar between women who did not undergo urodynamic study and those who underwent urodynamic study, 13.2% versus 18.4%, respectively (p = 0.753). Conclusion Preoperative urodynamic study had no impact on urinary incontinence cure outcomes as well as on urinary storage symptoms after the transobturator sling in women with stress urinary incontinence.

scholarly journals Prevalence of Overactive Bladder and Stress Urinary Incontinence in Women Who Have Sex with Women: An Internet-Based Survey

2014 ◽  
Vol 23 (11) ◽  
pp. 935-940 ◽  
Author(s):  
Renea M. Sturm ◽  
Benjamin N. Breyer ◽  
Chin-Shang Li ◽  
Leslee L. Subak ◽  
Jeannete S. Brown ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Overactive Bladder

scholarly journals Burch Retropubic Urethropexy for Genuine Stress Urinary Incontinence: A Review of Eight Cases

2017 ◽  
Vol 5 (2) ◽  
pp. 129-132
Author(s):  
Disha A Rajput ◽  
Shalini M Valecha ◽  
Manisha Sarwade ◽  
Shrikant Dhumale
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Urinary Continence ◽  
Urgency Incontinence ◽  
Patient’S Satisfaction ◽  
Satisfaction Index ◽  
Genuine Stress Urinary Incontinence

ABSTRACT Introduction Urinary incontinence (UI) is more common than any other chronic disease with the prevalence of approximately 23 and 55%. Among the various forms of UI, stress incontinence (SUI) is the most common (49%), with urgency incontinence (UUI) representing 21% and mixed type (MUI) at 29%. As it affects the quality-of-life of women, the restoration of urinary continence is one of the greatest challenges. Aim To review the cases of genuine SUI treated surgically by Burch retropubic urethropexy. Results We have managed surgically eight cases of genuine SUI by Burch retropubic urethropexy. On 1-year follow-up, none of the patients had any urinary complaints. All had responded well to surgery and patient's satisfaction index was good. Conclusion Since SUI is the commonest among incontinences, it is a challenge to diagnose and treat to improve quality-of-life of patients. Burch retropubic urethropexy is the gold standard treatment for SUI, especially if other indications exist for abdominal surgery. Even in the present era of less invasive vaginal procedures, results are comparable. How to cite this article Rajput DA, Valecha SM, Sarwade M, Dhumale S. Burch Retropubic Urethropexy for Genuine Stress Urinary Incontinence: A Review of Eight Cases. J South Asian Feder Menopause Soc 2017;5(2):129-132.

scholarly journals The effect of intravaginal electrical stimulation on the quality of life and changes in function and anatomy of pelvic floor in women with stress urinary incontinence

2012 ◽  
Vol 26 (1) ◽  
pp. 5-11
Author(s):  
Carneiro Erica ◽  
Araùjo Nazete ◽  
Cader Samaria ◽  
Fonseca Aluizio ◽  
Bittencourt Leila ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Electrical Stimulation ◽  
Stress Urinary Incontinence ◽  
Pelvic Floor ◽  
Pelvic Floor Muscles ◽  
Detrusor Muscle ◽  
Intravaginal Electrical Stimulation ◽  
Urine Loss

Abstract Introduction: Urinary incontinence (UI), according to the Committee of the International Continence Society Standards, is defined as any involuntary urine loss associated to exertion conditions. This urine loss can be called Stress Urinary Incontinence (SUI) and when the detrusor muscle becomes inactive Material and methods: The goal of this study was verifying intravaginal electrical stimulation effects on bladder floor mobility, pelvic floor muscles´ width, their contraction ability and the quality of life of 40 women whose age ranged from 35 to 55 and who were diagnosed with Stress Urinary Incontinence disorder. They were split into two groups: Geletro (underwent 16 perineal electrical stimulation sessions) and control group, Gc (no intervention). The variables were respectively evaluated by the following instruments: transvaginal ultrassonography (Toshiba trademark), Phenix electromyographic biofeedback and King´s Health Questionnaire. Results: The results were bladder floor mobility reduction (Δ% = -9,13%, p=0,0930), width increase on pelvic floor muscles (Δ% = 11,64%, p= 0,2924), both not significant, muscle strength increase due to biofeedback (Δ% =60,49%, p= 0,0001) and to AFA* (Δ% = 24,53%, p=0,0001), and significant decrease of all questionnaire scores: DOM 1 (Δ% = -50,00%, p = 0,000), DOM 2 (Δ% = -55,14%, p= 0,005), DOM 3 (Δ% =-74,98 %, p= 0,002), DOM 4 (Δ% = -73,87%, p= 0,002), DOM 5 (Δ% = -68,91%, p= 0,001), DOM 6 (Δ% = -85,90%, p= 0,000), DOM 7 (Δ% = -72,48%, p= 0,014), DOM 8 (Δ% =-71,88 %, p= 0,030), DOM 9Δ% =-73,29 %, p= 0,023) Conclusions: The Geletro group in comparison to the Gc which showed that intravaginal electrical stimulation improved the pelvic floor anatomically and functionally and also the quality of life of Geletro group. Stress Urinary Incontinence improvement could only be subjectively demonstrated.

scholarly journals Risk Factors for Urgency Incontinence in Women Undergoing Stress Urinary Incontinence Surgery

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Leslie M. Rickey ◽  
Liyuan Huang ◽  
David D. Rahn ◽  
Yvonne Hsu ◽  
Heather J. Litman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Symptom Severity ◽  
Bladder Function ◽  
Incontinence Episode ◽  
Incontinence Surgery ◽  
Fascial Sling ◽  
Patient Reported ◽  
Sui Surgery

Objective.To determine baseline variables associated with urgency urinary incontinence (UUI) in women presenting for stress urinary incontinence (SUI) surgery.Methods. Baseline data from two randomized trials enrolling 1,252 women were analyzed: SISTEr (fascial sling versus Burch colposuspension) and TOMUS (retropubic versus transobturator midurethral sling). Demographic data, POP-Q measures, and validated measures of symptom severity and quality of life were collected. Charlson Comorbidity Index (CCI) and Patient Health Questionnaire-9 were measured in TOMUS. Multivariate models were constructed with UUI and symptom severity as outcomes.Results. Over two-thirds of subjects reported bothersome UUI at baseline. TOMUS patients with more comorbidities had higher UDI irritative scores (CCI score 0 = 39.4, CCI score 1 = 42.1, and CCI score 2+ = 51.0,P=0.0003), and higher depression scores were associated with more severe UUI. Smoking, parity, prior incontinence surgery/treatment, prolapse stage, and incontinence episode frequency were not independently associated with UUI.Conclusions. There were no modifiable risk factors identified for patient-reported UUI in women presenting for SUI surgery. However, the direct relationships between comorbidity level, depression, and worsening of UUI/urgency symptoms may represent targets for preoperative intervention. Further research is necessary to elucidate the pathophysiologic mechanisms that explain the associations between these medical conditions and bladder function.

scholarly journals Rehabilitation treatment in patients with urinary incontinence

2020 ◽  
Vol 12 (3) ◽  
pp. 1-10
Author(s):  
Cvetanka Gjerakaroska-Savevska ◽  
Erieta Nikolikj-Dimitrova ◽  
Valentina Koevska ◽  
Biljana Mitrevska ◽  
Marija Gocevska ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Pelvic Floor ◽  
Behavioral Therapy ◽  
Pelvic Floor Muscle ◽  
Urinary Continence ◽  
Rehabilitation Treatment ◽  
The Individual

Urinary incontinence is the inability to control urination with spectrum of disturbances from periodical urinary leaks to complete inability to retain urine. It occurs more often in elderly and in women. Urinary incontinence has a great impact on general health and may reduce the quality of life. There are several types: stress urinary incontinence, urgent urinary incontinence, neurogenic urinary incontinence, overflow urinary incontinence. Stress urinary incontinence is the most frequent one and is due to pelvic floor muscle weakness. For assessment and treatment of these patients the individual approach is warranted. The treatment of these patients includes medications, behavioral therapy, biofeedback, pelvic floor muscle training, electrical stimulation, magnetic stimulation and surgery. Non-surgical treatment might be effective to prevent surgery. Rehabilitation treatment with pelvic floor exercises and physical modalities for patients with urinary incontinence is important for recovery of the urinary continence and improvement of quality of life in these patients.

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