Acid-base equilibrium during acute long-lasting experiments in artificially ventilated cats

1979 ◽  
Vol 236 (1) ◽  
pp. R126-R131
Author(s):  
C. Galletti ◽  
M. G. Maioli ◽  
E. R. Sanseverino

Experiments were carried out to study blood acid-base equilibrium in the cat during experiments with artificial ventilation. Blood acid-base equilibrium was examined in the arterial and venous blood by analyzing pH, carbon dioxide and oxygen partial pressure, and plasma bicarbonates. Artificial ventilation was regulated on the basis of this analysis; CO2 concentration in expired air was monitored throughout the experiment. An attempt was made to verify if artificial ventilation could be regulated indirectly only on the basis of CO2 concentration in expired air. The most appropriate acid-base equilibrium was maintained when CO2 concentration in expired air was kept within the range of 3.9-4.1%.

2007 ◽  
Vol 26 (3) ◽  
pp. 702-712 ◽  
Author(s):  
Yuichiro Himeda ◽  
Nobuko Onozawa-Komatsuzaki ◽  
Hideki Sugihara ◽  
Kazuyuki Kasuga

1999 ◽  
Vol 84 (6) ◽  
pp. 1997-2001
Author(s):  
Brandon J. Orr-Walker ◽  
Anne M. Horne ◽  
Margaret C. Evans ◽  
Andrew B. Grey ◽  
M. A. F. Murray ◽  
...  

Menopause is associated with an increase in venous bicarbonate concentrations that is reversible with hormone replacement therapy (HRT). However, the mechanism underlying this effect is not known. To address this question, we studied the changes in acid-base indexes in the arterialized venous blood of normal postmenopausal women commencing conjugated equine estrogen (0.625 mg/day), medroxyprogesterone acetate (MPA; 5 mg/day), their combination, or placebo, in a double blind randomized controlled study over 3 months. Serum bicarbonate concentrations decreased significantly in the groups receiving either MPA or estrogen plus MPA (P = 0.008). This trend was apparent as early as 2 days and reached 2.7 and 2.3 mmol/L in the respective groups by 3 months. Similar changes were seen with partial pressure of carbon dioxide (P = 0.04); a change of −0.7 kPa occurred in the estrogen plus MPA group at 3 months. There were no changes in bicarbonate concentrations or partial pressure of carbon dioxide in those receiving estrogen alone or placebo. Accompanying changes in blood pH were apparent in the estrogen plus MPA group, where there was an upward trend at 1 week (P = 0.056) and a significant change from baseline (+0.013) at 3 months (P = 0.03). In the whole group, the changes in pH were inversely correlated with those in urinary excretion of hydroxyproline (r = −0.44; P = 0.01). We conclude that HRT using conjugated estrogens and MPA produces small, but sustained, changes in acid-base status. These may contribute to the effects of HRT and menopause on many tissues and disease processes, including the development of osteoporosis.


1979 ◽  
Vol 16 (5) ◽  
pp. 612-618 ◽  
Author(s):  
Nicolaos E. Madias ◽  
Horacio J. Adrogué ◽  
Gary L. Horowitz ◽  
Jordan J. Cohen ◽  
William B. Schwartz

1942 ◽  
Vol 144 (2) ◽  
pp. 529-535
Author(s):  
Frank C. d'Elseaux ◽  
Frances C. Blackwood ◽  
Lucille E. Palmer ◽  
Katherine G. Sloman

1931 ◽  
Vol 90 (2) ◽  
pp. 607-617
Author(s):  
Edward Muntwyler ◽  
Natalie Limbach ◽  
Arthur H. Bill ◽  
Victor C. Myers

1926 ◽  
Vol 67 (1) ◽  
pp. 175-218
Author(s):  
John P. Peters ◽  
Harold A. Bulger ◽  
Anna J. Eisenman ◽  
Carter Lee

1926 ◽  
Vol 67 (1) ◽  
pp. 165-173 ◽  
Author(s):  
John P. Peters ◽  
Harold A. Bulger ◽  
Anna J. Eisenman

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