Neurohypophyseal secretion in hypovolemic rats: inverse relation to sodium appetite

1987 ◽  
Vol 252 (5) ◽  
pp. R889-R896 ◽  
Author(s):  
E. M. Stricker ◽  
J. A. Hosutt ◽  
J. G. Verbalis

Subcutaneous injection of polyethylene glycol (PEG) solution in rats produces exponential increases in secretion of arginine vasopressin (AVP) and oxytocin (OT) in proportion to the induced plasma volume deficits. Previously, we reported that acute water loads eliminated the neurohypophyseal hormone responses to hypovolemia, whereas hypertonic NaCl potentiated them. The present experiments indicated that AVP and OT secretion after PEG treatment were blunted by prior maintenance of rats on a sodium-deficient diet for 2 days. In contrast, plasma AVP and OT levels after PEG treatment were enhanced by prior adrenalectomy or ligation of the inferior vena cava or by concurrent administration of phentolamine in association with arterial hypotension. AVP and OT responses to hypovolemia were similarly potentiated in rats made uremic by bilateral nephrectomy or by puncturing their bladders. These results parallel previous findings that osmotic dilution and sodium deprivation each enhance the sodium appetite induced by PEG treatment in rats, whereas hyperosmolality, hypotension, and uremia each abolish it. Consequently, they support our previous hypothesis that sodium appetite is inversely related to the activity of hypothalamic oxytocinergic neurons.

1979 ◽  
Vol 237 (1) ◽  
pp. R45-R51 ◽  
Author(s):  
E. M. Stricker ◽  
A. H. Vagnucci ◽  
R. H. McDonald ◽  
F. H. Leenen

Plasma renin activities (PRA) and aldosterone concentrations increased in parallel over a wide range of plasma volume deficits produced in unanesthetized rats by extravascular administration of polyethylene glycol (PEG) solution. When PEG-treated rats were given water to drink, their intakes were proportional to PRA; when given water and 0.5 M NaCl, PRA and the steroid concentrations diminished concurrently in association with sodium consumption. Aldosterone concentrations and NaCl intakes were markedly enhanced after PEG treatment in rats maintained on a sodium-deficient diet for 4 days. On the other hand, a clear relation between PRA and water intake, and between circulating aldosterone levels and sodium intake, was not suggested by other experiments in this series. For example, bilateral nephrectomy abolished the rise in PRA during hypovolemia yet rats drank water normally. Moreover, aldosterone concentrations were substantially elevated by PEG treatment in the nephrectomized rats yet sodium appetite was abolished. These and other findings suggest that neither angiotensin nor aldosterone plays a prominent role in stimulating water and saline intakes during hypovolemia.


2006 ◽  
Vol 175 (4S) ◽  
pp. 392-393
Author(s):  
Fernando P. Secin ◽  
Zohar A. Dotari ◽  
Bobby Shayegan ◽  
Semra Olgac ◽  
Bertrand Guillonneau ◽  
...  

1998 ◽  
Vol 6 (1) ◽  
pp. 51-72
Author(s):  
Allan J. Pantuck ◽  
Kenneth B. Cummings

1999 ◽  
Vol 1 ◽  
pp. S64-S64
Author(s):  
A OZYUREK ◽  
Z KURUGOL ◽  
C DORAK ◽  
E LEVENT ◽  
A EGEMEN ◽  
...  

VASA ◽  
1999 ◽  
Vol 28 (4) ◽  
pp. 289-292 ◽  
Author(s):  
Tiesenhausen ◽  
Amann ◽  
Thalhammer ◽  
Aschauer

Congenital anomalies of the caval vein are often associated with other abnormities such as heart defects, situs inversus or a polysplenia-asplenia-syndrome. An isolated, congenital malformation like aplasia of the inferior vena cava is a rare finding. A review of the embryology and abnormities, diagnostics, clinical signs and treatment is given together with the histories of two patients having thrombosis of the lower extremities and pelvic veins, caused by aplasia of the inferior vena cava. After thrombotic complications caused by vena cava aplasia there is high risk of recurrence. Those patients should be anticoagulated for lifetime.


VASA ◽  
2014 ◽  
Vol 43 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Paweł Gać ◽  
Małgorzata Kuśmierska ◽  
Przemysław Jaźwiec ◽  
Magdalena Bolt ◽  
Anna Kuśmierska ◽  
...  

VASA ◽  
2011 ◽  
Vol 40 (2) ◽  
pp. 157-162 ◽  
Author(s):  
Piecuch ◽  
Wiewiora ◽  
Nowowiejska-Wiewiora ◽  
Szkodzinski ◽  
Polonski

The placement of an inferior vena cava (IVC) filter is a therapeutic method for selected patients with deep venous thrombosis and pulmonary embolism. However, insertion and placement of the filter may be associated with certain complications. For instance, retroperitoneal hematoma resulting from perforation of the wall by the filter is such a very rare but serious complication. We report the case of a 64-year-old woman with perforation of the IVC wall and consecutive hematoma caused by the filter who was treated surgically.


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