scholarly journals Functional MRI detects perfusion impairment in renal allografts with delayed graft function

2015 ◽  
Vol 308 (12) ◽  
pp. F1444-F1451 ◽  
Author(s):  
Katja Hueper ◽  
Faikah Gueler ◽  
Jan Hinrich Bräsen ◽  
Marcel Gutberlet ◽  
Mi-Sun Jang ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Transplantation ◽  
Functional Mri ◽  
Graft Loss ◽  
Graft Function ◽  
Resistance Index ◽  
Deceased Donor ◽  
Renal Perfusion ◽  
Delayed Graft Function ◽  
Renal Outcome

Delayed graft function (DGF) after kidney transplantation is not uncommon, and it is associated with long-term allograft impairment. Our aim was to compare renal perfusion changes measured with noninvasive functional MRI in patients early after kidney transplantation to renal function and allograft histology in biopsy samples. Forty-six patients underwent MRI 4–11 days after transplantation. Contrast-free MRI renal perfusion images were acquired using an arterial spin labeling technique. Renal function was assessed by estimated glomerular filtration rate (eGFR), and renal biopsies were performed when indicated within 5 days of MRI. Twenty-six of 46 patients had DGF. Of these, nine patients had acute rejection (including borderline), and eight had other changes (e.g., tubular injury or glomerulosclerosis). Renal perfusion was significantly lower in the DGF group compared with the group with good allograft function (231 ± 15 vs. 331 ± 15 ml·min−1·100 g−1, P < 0.001). Living donor allografts exhibited significantly higher perfusion values compared with deceased donor allografts ( P < 0.001). Renal perfusion significantly correlated with eGFR ( r = 0.64, P < 0.001), resistance index ( r = −0.57, P < 0.001), and cold ischemia time ( r = −0.48, P < 0.01). Furthermore, renal perfusion impairment early after transplantation predicted inferior renal outcome and graft loss. In conclusion, noninvasive functional MRI detects renal perfusion impairment early after kidney transplantation in patients with DGF.

scholarly journals SP777EARLY RENAL PERFUSION IMPAIRMENT QUANTIFIED FUNCTIONAL MRI IS PREDICTIVE FOR DELAYED RENAL GRAFT FUNCTION AND RENAL OUTCOME ONE YEAR AFTER KIDNEY TRANSPLANTATION

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii634-iii635
Author(s):  
Katja Hueper ◽  
Faikah Gueler ◽  
Jan Hinrich Bräsen ◽  
Marcel Gutberlet ◽  
Mi-Sun Jang ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Functional Mri ◽  
Graft Function ◽  
Renal Perfusion ◽  
Renal Outcome ◽  
Renal Graft ◽  
One Year

scholarly journals Endogenous intronic antisense long non-coding RNA, MGAT3-AS1, and kidney transplantation

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Subagini Nagarajah ◽  
Shengqiang Xia ◽  
Marianne Rasmussen ◽  
Martin Tepel
Keyword(s):  
Kidney Transplantation ◽  
Predictive Value ◽  
Graft Function ◽  
Deceased Donor ◽  
Delayed Graft Function ◽  
Transplant Recipients ◽  
Donor Kidney ◽  
Non Coding Rna ◽  
Deceased Donor Kidney ◽  
Long Non Coding Rna

Abstract β-1,4-mannosylglycoprotein 4-β-N-acetylglucosaminyltransferase (MGAT3) is a key molecule for the innate immune system. We tested the hypothesis that intronic antisense long non-coding RNA, MGAT3-AS1, can predict delayed allograft function after kidney transplantation. We prospectively assessed kidney function and MGAT3-AS1 in 129 incident deceased donor kidney transplant recipients before and after transplantation. MGAT3-AS1 levels were measured in mononuclear cells using qRT-PCR. Delayed graft function was defined by at least one dialysis session within 7 days of transplantation. Delayed graft function occurred in 22 out of 129 transplant recipients (17%). Median MGAT3-AS1 after transplantation was significantly lower in patients with delayed graft function compared to patients with immediate graft function (6.5 × 10−6, IQR 3.0 × 10−6 to 8.4 × 10−6; vs. 8.3 × 10−6, IQR 5.0 × 10−6 to 12.8 × 10−6; p < 0.05). The median preoperative MGAT3-AS1 was significantly lower in kidney recipients with delayed graft function (5.1 × 10−6, IQR, 2.4 × 10−6 to 6.8 × 10−6) compared to recipients with immediate graft function (8.9 × 10−6, IQR, 6.8 × 10−6 to 13.4 × 10−6; p < 0.05). Receiver-operator characteristics showed that preoperative MGAT3-AS1 predicted delayed graft function (area under curve, 0.83; 95% CI, 0.65 to 1.00; p < 0.01). We observed a positive predictive value of 0.57, and a negative predictive value of 0.95. Long non-coding RNA, MGAT3-AS1, indicates short-term outcome in patients with deceased donor kidney transplantation.

Gene Expression Patterns in Deceased Donor Kidneys Developing Delayed Graft Function After Kidney Transplantation

2008 ◽  
Vol 85 (4) ◽  
pp. 626-635 ◽  
Author(s):  
Valeria R. Mas ◽  
Kellie J. Archer ◽  
Kenneth Yanek ◽  
Catherine I. Dumur ◽  
Maria I. Capparuccini ◽  
...  
Keyword(s):  
Gene Expression ◽  
Kidney Transplantation ◽  
Expression Patterns ◽  
Graft Function ◽  
Deceased Donor ◽  
Delayed Graft Function ◽  
Gene Expression Patterns

MO975INFLUENCE OF THE TYPE OF DIALYSIS ON SHORT-TERM KIDNEY TRANSPLANT RESULTS. EXPERIENCE OF OUR  CENTER

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Maria Lanau Martinez ◽  
Marta Artamendi Larrañaga ◽  
Celia Garijo Pacheco ◽  
Iñigo Gaston Najarro ◽  
Guillermo Pereda Bengoa ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Transplantation ◽  
Acute Rejection ◽  
Graft Function ◽  
Vascular Complications ◽  
Group Versus ◽  
Infectious Complications ◽  
Delayed Graft Function ◽  
Dialysis Technique

Abstract Background and Aims Kidney transplantation (KT) is considered to be the best option for renal replacement therapy (RRT) in patients with advanced chronic kidney disease, surpassing any dialysis technique in quality and life expectancy. However, results in terms of how pre-KT dialysis technique influences graft and recipient survival are mixed. Some studies show a higher incidence of vascular complications in the immediate post-transplant period and higher rates of acute rejection in patients coming from peritoneal dialysis (PD) versus those coming from hemodialysis (HD) while others observe a lower incidence of delayed graft function in the PD group of patients versus those on HD. Our objective is to analyze if there are differences in immediate post-kidney transplantation and at 6 months of follow-up depending on the pre-KT dialysis technique, PD versus HD. Method Observational study of all patients with KT of cadaveric donor from the beginning of the KT program in our Center, from August 2011 to August 2019. We analyzed the characteristics of donors and recipients according to the technique (PD/HD), the evolution and complications in the immediate post-KT, as well as results at 6 months of follow-up in terms of complications, renal function and survival of the recipient and the graft. For statistical analysis we used SPSS 25. We compared qualitative variables by means of Xi2 test, and quantitative variables by t of Student, or U of Mann-Whitney if the variables did not follow a normal distribution. A value of p &lt;0.05 was considered significant. Results 121 patients were included, 71 of whom were in the HD group, versus 50 who were in the PD group. The recipients in the HD group were significantly older (57.2 vs 51.6 years, p 0,02) and stayed on dialysis longer (33.8 vs 26.8 months). We observed no difference in the recipient's cardiovascular history, except for increased smoking in the HD group (52.1% vs. 24%). The donor-recipient immune profile was similar in both groups. As for the incidence of delayed graft function, it was significantly lower in the PD group (14.9% vs 34.3%), finding no difference in renal function at hospital discharge or in days of admission. In the first 6 months of follow-up, we found no differences in terms of vascular, urological or infectious complications. There were also no differences in the incidence of acute rejection, renal function measured by creatinine (HD 1.47 vs DP 1.50 mg/dl) and proteinuria (HD 200 vs DP 216 mg/24 hours). Graft and recipient survival at 6 months of TR follow-up were similar in both groups. Conclusion In our experience, we have not found differences in the evolution at 6 months of the KT according to the modality of dialysis , nor greater incidence of vascular, immunological or other complications, with a survival of graft and receptor superimposable between both groups, PD or HD.

Sign in / Sign up

Export Citation Format

Share Document