Measurement of pleural pressure at low and high frequencies in normal rabbits

1987 ◽  
Vol 63 (3) ◽  
pp. 1142-1146 ◽  
Author(s):  
D. A. Chartrand ◽  
T. H. Ye ◽  
J. M. Maarek ◽  
H. K. Chang
Keyword(s):  
Body Surface ◽  
Pressure Transducer ◽  
Esophageal Pressure ◽  
Pleural Pressure ◽  
Opening Pressure ◽  
High Frequencies ◽  
Occlusion Test ◽  
Airway Opening ◽  
Catheter Tip ◽  
The Relationship

In eight tracheotomized adult rabbits placed in the supine position, we employed a catheter-tip piezoresistive pressure transducer to measure esophageal pressure (Pes) and assessed the validity of taking the changes in Pes to be the changes in pleural pressure (Ppl). We applied an occlusion test in which the tracheal cannula was occluded during either spontaneous inspiratory efforts or body surface oscillations ranging from 3 to 50 Hz. The relationship between Pes and airway opening pressure (Pao) was recorded. In all instances, the changes in Pes and Pao were virtually identical in both amplitude and phase. We conclude that, as evaluated by the occlusion test, a catheter-tip pressure transducer placed in the esophagus of rabbits can give adequate estimation of local pleural changes up to at least 50 Hz.

Liquid-filled esophageal catheter for measuring pleural pressure in preterm neonates

1989 ◽  
Vol 67 (2) ◽  
pp. 889-893 ◽  
Author(s):  
A. L. Coates ◽  
G. M. Davis ◽  
P. Vallinis ◽  
E. W. Outerbridge
Keyword(s):  
Chest Wall ◽  
Precise Measurement ◽  
Esophageal Pressure ◽  
Lung Mechanics ◽  
Pleural Pressure ◽  
Preterm Neonates ◽  
Alveolar Pressure ◽  
Occlusion Test ◽  
Catheter System ◽  
Airway Opening

The precise measurement of esophageal pressure (Pes) as a reflection of pleural pressure (Ppl) is crucial to the measurement of lung mechanics in the newborn. The fidelity of Pes as a measurement of Ppl is determined by the occlusion test in which, during respiratory efforts against an occlusion at the airway opening, changes in pressure (delta Pao) (Pao is assumed to be equal to alveolar pressure) are shown to be equal to changes in Pes (delta Pes). Eight intubated premature infants (640–3,700 g) with chest wall distortion were studied using a water-filled catheter system to measure Pes. During the occlusion test, all patients had a finite region of the esophagus where delta Pes equaled delta Pao, which corresponded to points in the esophagus above the cardia but below the carina. In conclusion, even in the presence of chest wall distortion, a liquid-filled catheter with the tip between the cardia and carina can provide an accurate measurement of Ppl, even in the very small premature infant with chest wall distortion.

Effects of surface tension and viscosity on airway reopening

1990 ◽  
Vol 69 (1) ◽  
pp. 74-85 ◽  
Author(s):  
D. P. Gaver ◽  
R. W. Samsel ◽  
J. Solway
Keyword(s):  
Surface Tension ◽  
Fluid Viscosity ◽  
Opening Pressure ◽  
Viscous Forces ◽  
Considerable Portion ◽  
Airway Opening ◽  
Wall Compliance ◽  
Large Opening ◽  
Surface Tension Forces ◽  
The Relationship

We studied airway opening in a benchtop model intended to mimic bronchial walls held in apposition by airway lining fluid. We measured the relationship between the airway opening velocity (U) and the applied airway opening pressure in thin-walled polyethylene tubes of different radii (R) using lining fluids of different surface tensions (gamma) and viscosities (mu). Axial wall tension (T) was applied to modify the apparent wall compliance characteristics, and the lining film thickness (H) was varied. Increasing mu or gamma or decreasing R or T led to an increase in the airway opening pressures. The effect of H depended on T: when T was small, opening pressures increased slightly as H was decreased; when T was large, opening pressure was independent of H. Using dimensional analysis, we found that the relative importance of viscous and surface tension forces depends on the capillary number (Ca = microU/gamma). When Ca is small, the opening pressure is approximately 8 gamma/R and acts as an apparent “yield pressure” that must be exceeded before airway opening can begin. When Ca is large (Ca greater than 0.5), viscous forces add appreciably to the overall opening pressures. Based on these results, predictions of airway opening times suggest that airway closure can persist through a considerable portion of inspiration when lining fluid viscosity or surface tension are elevated.

Volume-time profile during relaxed expiration in the normal dog

1985 ◽  
Vol 59 (3) ◽  
pp. 732-737 ◽  
Author(s):  
J. H. Bates ◽  
M. Decramer ◽  
D. Chartrand ◽  
W. A. Zin ◽  
A. Boddener ◽  
...  
Keyword(s):  
Respiratory System ◽  
Time Course ◽  
Elastic Equilibrium ◽  
Esophageal Pressure ◽  
Time Profile ◽  
Time Interval ◽  
Opening Pressure ◽  
Lung Inflation ◽  
Volume Comparison ◽  
Airway Opening

Airway opening pressure, esophageal pressure, and flow were obtained during relaxed expirations in two normal anesthetized paralyzed dogs. The signal-to-noise ratio in the flow signals was greatly increased by averaging 10 different signals obtained with the same lung inflation volume. Numerical integration of an averaged flow signal then yielded the time course of the volume of the respiratory system above functional residual capacity (the elastic equilibrium volume). Comparison of volume signals obtained with different inflation volumes suggests that the resistance of the respiratory system increases with flow. The flow-volume and semilog volume curves show that expiration is induced by two apparently separate mechanisms: one causes emptying of most of the expired volume over a time interval of much less than 1 s, whereas the other contributes a relatively small amount to the expired volume over a significantly longer time (greater than or equal to 1 s). We postulate the first mechanism to be due to that of the respiratory system behaving like a single unit, with an elastance that is slightly volume dependent, emptying through a single airway which has a resistance that increases with flow. From the nature of airway opening pressure and esophageal pressure measured after occlusion in midexpiration, we conclude that the second mechanism is due to the viscoelastic properties (i.e., creep) of the respiratory system. The properties are manifest mainly in the chest wall.

Mean airway opening pressure as an index of inspiratory muscle task intensity

1986 ◽  
Vol 60 (1) ◽  
pp. 304-306 ◽  
Author(s):  
F. D. McCool ◽  
D. E. Leith
Keyword(s):  
Endotracheal Tube ◽  
Inspiratory Muscle ◽  
Muscle Training ◽  
Opening Pressure ◽  
Mean Values ◽  
Time Integral ◽  
Pressure Time ◽  
Airway Opening ◽  
Inspiratory Resistance ◽  
The Relationship

The relationship between mean values of pressure (pressure-time integral including both inspiration and expiration) measured at the airway opening (Pao) and in the esophagus (Pes) is described for ventilation on a variety of external inspiratory resistances. Pao/Pes was 0.85 or greater when the external inspiratory resistance was a 4.0-mm or smaller endotracheal tube adaptor. Additionally, Pao can be easily and accurately measured by a slowly responding mechanical manometer. This device is simple in design, unpowered, inexpensive, and can be used outside the laboratory as part of an inspiratory muscle training program.

Airway resistance measured in liquid-trapped guinea pig lungs by micropuncture

1988 ◽  
Vol 65 (6) ◽  
pp. 2446-2452
Author(s):  
Y. L. Lai ◽  
S. Ganesan ◽  
S. J. Lai-Fook
Keyword(s):  
Guinea Pig ◽  
Airway Resistance ◽  
Close Association ◽  
Maximum Volume ◽  
Liquid Pressure ◽  
Opening Pressure ◽  
Airway Narrowing ◽  
Airway Opening ◽  
Liquid Trapping ◽  
The Relationship

We studied the relationship between bronchoconstriction and the degree of trapping in saline-filled lungs isolated from guinea pigs postmortem after rapid exsanguination. Airway resistance was measured in nine lungs, and in five lungs the site of airway narrowing was located radiographically. Animals were anesthetized with pentobarbital sodium, degassed by O2 absorption, then rapidly exsanguinated when O2 absorption was almost complete. Liquid trapping was assessed from the pressure-volume behaviour measured in saline-filled lungs. During a slow deflation from maximum volume, alveolar liquid pressure (Palv) was measured by the micropipette-servonulling method, airway opening pressure (Pao) by a strain gauge, and flow rate (Q) by weighing a reservoir connected to the airway. Airway resistance (Raw) was calculated at different lung volumes from the relationship: Raw = (Palv-Pao)/Q. In untreated lungs, Raw and fluid trapping were relatively high, and severe bronchoconstriction occurred at the level of the main stem and lobar bronchi. Nifedipine infusion reduced Raw 40-fold and decreased trapping. Raw was further reduced 10-fold and fluid trapping was minimal in lungs pretreated with nifedipine before exsanguination. Results suggest a close association between bronchoconstriction and fluid trapping in guinea pig lungs.

Measurement of pleural pressure in neonates

1982 ◽  
Vol 52 (2) ◽  
pp. 491-494 ◽  
Author(s):  
M. I. Asher ◽  
A. L. Coates ◽  
J. M. Collinge ◽  
J. Milic-Emili
Keyword(s):  
Body Position ◽  
Balloon Catheter ◽  
Esophageal Pressure ◽  
Indirect Measurement ◽  
Pleural Pressure ◽  
Internal Diameter ◽  
Term Neonates ◽  
Esophageal Balloon ◽  
Airway Opening ◽  
Pressure Changes

The indirect measurement of pleural pressure in neonates is obtained from measurements of esophageal pressure (Pes) with either a liquid-filled catheter or an esophageal balloon-catheter system. The purpose of this investigation was to assess the validity of the water-filled esophageal catheter by comparing the simultaneous changes in Pes and airway opening pressure (Pao) during occluded respiratory efforts. Equal changes in Pes and Pao under this condition indicate that Pes is a valid measurement of pleural pressure. In six healthy unsedated term neonates (aged 2–3 days) we measured Pes in the lower third of the esophagus with a water-filled catheter of eight French gage (FC), which has a 2-mm internal diameter. During occlusions, changes in Pes and Pao were almost identical in magnitude and timing in each body position studied (right lateral, prone, and supine). We conclude that the water-filled 8-FG esophageal catheter gives an accurate measurement of pleural pressure changes in healthy neonates.

The use of Body Surface Index as a Better Clinical Health indicators Compare to Body Mass Index and Body Surface Area for Clinical Application

2018 ◽  
pp. 131-136
Author(s):  
Shirazu I. ◽  
Theophilus. A. Sackey ◽  
Elvis K. Tiburu ◽  
Mensah Y. B. ◽  
Forson A.
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Clinical Application ◽  
Body Surface ◽  
Body Height ◽  
Health Indicators ◽  
The Body ◽  
Body Parameters ◽  
The Relationship ◽  
Individual Body

The relationship between body height and body weight has been described by using various terms. Notable among them is the body mass index, body surface area, body shape index and body surface index. In clinical setting the first descriptive parameter is the BMI scale, which provides information about whether an individual body weight is proportionate to the body height. Since the development of BMI, two other body parameters have been developed in an attempt to determine the relationship between body height and weight. These are the body surface area (BSA) and body surface index (BSI). Generally, these body parameters are described as clinical health indicators that described how healthy an individual body response to the other internal organs. The aim of the study is to discuss the use of BSI as a better clinical health indicator for preclinical assessment of body-organ/tissue relationship. Hence organ health condition as against other body composition. In addition the study is `also to determine the best body parameter the best predict other parameters for clinical application. The model parameters are presented as; modeled height and weight; modelled BSI and BSA, BSI and BMI and modeled BSA and BMI. The models are presented as clinical application software for comfortable working process and designed as GUI and CAD for use in clinical application.

Hearing loss in diabetics

1993 ◽  
Vol 107 (3) ◽  
pp. 179-182 ◽  
Author(s):  
J. R. Cullen ◽  
M. J. Cinnamond
Keyword(s):  
Hearing Loss ◽  
Sensorineural Deafness ◽  
Insulin Dosage ◽  
Speech Discrimination ◽  
Low Frequencies ◽  
High Frequencies ◽  
History Of ◽  
Insulin Dependent ◽  
Stapedial Reflex ◽  
The Relationship

The relationship between diabetes and senbsorineural hearing loss has been disputed. This study compares 44 insulin-dependent diabetics with 38 age and sex matched controls. All had pure tone and speech audiometry performed, with any diabetics showing sensorineural deafness undergoing stapedial reflecx decat tests. In 14 diabetics stapedial reflex tests showed no tone decay in any patient, but seven showed evidence of recruitment. Analysis of vaiance showed the diabetics to be significantly deafer than the control population.The hearing loss affected high frequencies in both sexes, but also low frequencies in the male. Speech discrimination scores showed no differences. Further analysis by sex showed the males to account for most of the differences. Analysys of the audiograms showered mostly a high tone loss. Finally duration of disbetes, insulin dosage and family history of diabtes were not found to have a significant effect on threshold.

Pleural pressure increases during inspiration in the zone of apposition of diaphragm to rib cage

1988 ◽  
Vol 65 (5) ◽  
pp. 2207-2212 ◽  
Author(s):  
W. F. Urmey ◽  
A. De Troyer ◽  
K. B. Kelly ◽  
S. H. Loring
Keyword(s):  
Esophageal Pressure ◽  
Pleural Pressure ◽  
Abdominal Pressure ◽  
Transdiaphragmatic Pressure ◽  
Rib Cage ◽  
Direct Measurements ◽  
Anesthetized Dogs ◽  
Theoretical Mechanism ◽  
Phrenic Stimulation ◽  
Anatomic Region

The zone of apposition of diaphragm to rib cage provides a theoretical mechanism that may, in part, contribute to rib cage expansion during inspiration. Increases in intra-abdominal pressure (Pab) that are generated by diaphragmatic contraction are indirectly applied to the inner rib cage wall in the zone of apposition. We explored this mechanism, with the expectation that pleural pressure in this zone (Pap) would increase during inspiration and that local transdiaphragmatic pressure in this zone (Pdiap) must be different from conventionally determined transdiaphragmatic pressure (Pdi) during inspiration. Direct measurements of Pap, as well as measurements of pleural pressure (Ppl) cephalad to the zone of apposition, were made during tidal inspiration, during phrenic stimulation, and during inspiratory efforts in anesthetized dogs. Pab and esophageal pressure (Pes) were measured simultaneously. By measuring Ppl's with cannulas placed through ribs, we found that Pap consistently increased during both maneuvers, whereas Ppl and Pes decreased. Whereas changes in Pdi of up to -19 cmH2O were measured, Pdiap never departed from zero by greater than -4.5 cmH2O. We conclude that there can be marked regional differences in Ppl and Pdi between the zone of apposition and regions cephalad to the zone. Our results support the concept of the zone of apposition as an anatomic region where Pab is transmitted to the interior surface of the lower rib cage.

Sign in / Sign up

Export Citation Format

Share Document