Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion

2000 ◽  
Vol 88 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Yudai Takarada ◽  
Yutaka Nakamura ◽  
Seiji Aruga ◽  
Tetuya Onda ◽  
Seiji Miyazaki ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Resistance Exercise ◽  
Inflammatory Responses ◽  
Plasma Concentrations ◽  
Lipid Peroxide ◽  
Vascular Occlusion ◽  
Plasma Growth Hormone ◽  
Leg Extension ◽  
Low Intensity ◽  
Before And After

Hormonal and inflammatory responses to low-intensity resistance exercise with vascular occlusion were studied. Subjects ( n = 6) performed bilateral leg extension exercise in the seated position, with the proximal end of their thigh compressed at 214 ± 7.7 (SE) mmHg throughout the session of exercise by means of a pressure tourniquet. Mean intensity and quantity of the exercise were 20% of 1 repetition maximum and 14 repetitions × 5 sets, respectively. In each set, the subjects repeated the movement until exhaustion. Plasma concentrations of growth hormone (GH), norepinephrine (NE), lacate (La), lipid peroxide (LP), interleukin-6 (IL-6), and activity of creatine phosphokinase (CPK) were measured before and after the exercise was finished and the tourniquet was released. Concentrations of GH, NE, and La consistently showed marked, transient increases after the exercise with occlusion, whereas they did not change a great deal after the exercise without occlusion (control) done at the same intensity and quantity. Notably, concentration of GH reached a level ∼290 times as high as that of the resting level 15 min after the exercise. IL-6 concentration showed a much more gradual increase and was maintained at a slightly higher level than in the control even 24 h after exercise. Concentrations of LP and CPK showed no significant change. The results suggest that extremely light resistance exercise combined with occlusion greatly stimulates the secretion of GH through regional accumulation of metabolites without considerable tissue damage.

RELATIONSHIP BETWEEN LAMB BIRTH WEIGHTS AND FETAL PLASMA GROWTH HORMONE AND INSULIN CONCENTRATIONS

1986 ◽  
Vol 66 (4) ◽  
pp. 995-1001
Author(s):  
G. J. MEARS
Keyword(s):  
Growth Hormone ◽  
Fetal Growth ◽  
Plasma Insulin ◽  
Plasma Concentrations ◽  
Maternal Plasma ◽  
Metabolic Clearance ◽  
Plasma Growth Hormone ◽  
Fetal Plasma ◽  
Plasma Gh ◽  
Ovine Fetal

Plasma concentrations of growth hormone (GH) and insulin were monitored in 11 chronically cannulated ovine fetuses and their mothers during the last month of gestation to obtain information on the role that these hormones have in determining fetal growth rate. Maternal plasma GH and insulin concentrations were independent of stage of gestation and lamb birth weights. Fetal plasma insulin concentrations were episodic in nature, independent of stage of gestation, and tended to be higher in fetuses that were heavier at birth. Fetal plasma GH concentrations were only slightly episodic in nature, were tenfold higher than maternal levels at 116–124 d gestation and increased by approximately another 25% prior to parturition. Fetal plasma GH concentrations were negtively correlated with lamb birth weights. In twin preparations, fetal plasma GH concentrations were significantly lower in the twin that was heaviest at birth. The lower GH concentrations found in faster growing fetuses are suggestive of a more rapid metabolic clearance of GH by the tissues of these animals. The results indicate that circulating fetal GH and, possibly, insulin are involved in determining the rate of ovine-fetal growth. Key words: Ovine birth weights, fetal GH, fetal insulin, fetal growth

scholarly journals Growth hormone in infant malnutrition: the arginine test in marasmus and kwashiorkor

1971 ◽  
Vol 26 (2) ◽  
pp. 169-175 ◽  
Author(s):  
F. Beas ◽  
I. Contreras ◽  
A. Maccioni ◽  
Sara Arenas
Keyword(s):  
Growth Hormone ◽  
Plasma Concentrations ◽  
Intravenous Dose ◽  
Control Group ◽  
Plasma Growth Hormone ◽  
Protein Deprivation ◽  
Arginine Test

1. Experiments in children and in animals seem to demonstrate that in marasmic malnutrition there is a reduction in the secretion of growth hormone. To study this problem the fasting, resting plasma concentrations of growth hormone were determined, before, and 45 and 60 min after, stimulation with an intravenous dose of arginine, in six infants with marasmus, in six infants with kwashiorkor and in five normal infants.2. The values of plasma growth hormone (4·5 ± 0·97 ng/ml) in marasmic infants were significantly (P < 0·001) lower than those of the controls (7·8 ± 2·6 ng/ml), and responded little to stimulation with arginine (5·1 and 5·8 ng/ml at 45 and 60 min respectively), in contrast to those in the control group, which rose to 16·4 and 14·6 ng/ml. In children with kwashiorkor the values were very variable, but generally high, and showed little response (25·6 ± 13·3 before and 25·0 ± 17·6 and 14·2 ± 5·3 ng/ml at 45 and 60 min after stimulation respectively).3. These results demonstrate that the responses of the hypophysis to deprivation of calories and protein (marasmus) and to protein deprivation (kwashiorkor) are different: in marasmus there is a progressive adaptation, with low secretion and poor reaction to stimulation, whereas in kwashiorkor the process is acute with high basal values of plasma growth hormone.

scholarly journals Postprandial changes in plasma growth hormone and insulin concentrations in calves before and after weaning

2004 ◽  
Vol 13 (Suppl. 1) ◽  
pp. 413-416
Author(s):  
K. Katoh ◽  
G. Furukawa ◽  
Y. Kobayashi ◽  
Y. Obara
Keyword(s):  
Growth Hormone ◽  
Plasma Growth Hormone ◽  
Before And After

Menopausal Status Impairs Acute Inflammatory Recovery from Resistance Exercise

2020 ◽  
pp. 1-7
Author(s):  
Emily Kullman ◽  
Christopher L. Axelrod ◽  
Emily Kullman ◽  
Kathleen D. Little ◽  
Kenneth E. Sparks
Keyword(s):  
Resistance Exercise ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Inflammatory Responses ◽  
Menopausal Status ◽  
Leg Extension ◽  
Single Bout ◽  
Body Resistance ◽  
Post Menopausal ◽  
Hormonal Milieu

The purpose of this study was to explore the effects of menopausal status on inflammatory responses to a single bout of resistance exercise (RE). Twenty pre- (N=10) or post- menopausal (N=10) women aged 18- 65 years had one repetition maximum (1RM) determined for the chest and leg press, leg and biceps curl, vertical pull down, triceps and leg extension exercises. On a separate day, participants completed a session of full body resistance exercise (RE) during which subjects performed three sets of 10 repetitions at 75% 1RM for the aforementioned exercises. Blood samples were obtained prior to, immediately, and one hour after exercise. Changes in interleukin-6, -10, and transforming growth factor beta (IL-6, -10, and TGF-β1) were determined via enzyme-linked immunosorbent assays (ELISA). IL-6 significantly increased (P<0.05) over time in both groups. Immediately post exercise levels of IL-10 were significantly lower (P<0.05) in the post-menopausal group. Changes in IL-10 correlated with 17β-estradiol levels (r2=0.45, P<0.001). Menopausal status impaired inflammatory recovery following acute RE. These changes may be attributed to menopause-induced perturbations to the hormonal milieu.

scholarly journals Oxygen Uptake On-Kinetics during Low-Intensity Resistance Exercise: Effect of Exercise Mode and Load

2019 ◽  
Vol 16 (14) ◽  
pp. 2524 ◽  
Author(s):  
Victor M. Reis ◽  
Eduardo B. Neves ◽  
Nuno Garrido ◽  
Ana Sousa ◽  
André L. Carneiro ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Resistance Exercise ◽  
Bench Press ◽  
Slow Component ◽  
Kinetics Parameters ◽  
Leg Extension ◽  
Low Intensity ◽  
Vo2 Kinetics ◽  
Exercise Effect ◽  
Constant Work Rate

Oxygen uptake (VO2) kinetics has been analyzed through mathematical modeling of constant work-rate exercise, however, the exponential nature of the VO2 response in resistance exercise is currently unknown. The present work assessed the VO2 on-kinetics during two different sub maximal intensities in the inclined bench press and in the seated leg extension exercise. Twelve males (age: 27.2 ± 4.3 years, height: 177 ± 5 cm, body mass: 79.0 ± 10.6 kg and estimated body fat: 11.4 ± 4.1%) involved in recreational resistance exercise randomly performed 4-min transitions from rest to 12% and 24% of 1 repetition maximum each, of inclined bench press (45°) and leg extension exercises. During all testing, expired gases were collected breath-by-breath with a portable gas analyzer (K4b2, Cosmed, Italy) and VO2 on-kinetics were identified using a multi-exponential mathematical model. Leg extension exercise exhibited a higher R-square, compared with inclined bench press, but no differences were found in-between exercises for the VO2 kinetics parameters. VO2 on-kinetics seems to be more sensitive to muscle related parameters (upper vs. lower body exercise) and less to small load variations in the resistance exercise. The absence of a true slow component indicates that is possible to calculate low-intensity resistance exercise energy cost based solely on VO2 measurements.

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