Somatosensory cortex activity related to position and force

1983 ◽  
Vol 49 (5) ◽  
pp. 1216-1229 ◽  
Author(s):  
V. A. Jennings ◽  
Y. Lamour ◽  
H. Solis ◽  
C. Fromm
Keyword(s):  
Somatosensory Cortex ◽  
Single Neurons ◽  
Limb Position ◽  
Neuronal Populations ◽  
Area 3A ◽  
Position Type ◽  
State Position ◽  
Limb Posture

1. The relation of somatosensory cortex (SI) neuronal activity to actively maintained limb posture was examined by recording from single neurons in the SI of monkeys trained to hold the forearm at different pronation-supination postures and to exert different directions and magnitudes of steady torque. 2. Neurons related to limb position were, in most cases (89%), also related to torque exerted by the limb. Very few neurons related to only position or only torque were found. 3. Two categories of position- and torque-related neurons were found, type 1 and type 2. Type 1 eurneuronal activity resembled the pattern of activity seen in the pronator and supinator muscles; neurons more active with supinating torque also became more active with supinated position, while neurons related to pronating torque were also related to pronated position. Type 2 neurons had a noncongruent relation to position and torque; neurons more active with supinating torque became more active with pronated position, while neurons related to pronating torque were related to supinated position. 4. Position- and torque-related neurons were characterized by having predominantly noncutaneous peripheral inputs and were concentrated in two SI regions identified as area 3a and area 2. 5. It is hypothesized that during actively held limb postures, the activity of the type 1 and type 2 neuronal populations in SI is sufficient to signal uniquely the steady-state position of the limb and the force exerted by the limb.

Threshold Firing Frequency–Current Relationships of Neurons in Rat Somatosensory Cortex: Type 1 and Type 2 Dynamics

2004 ◽  
Vol 92 (4) ◽  
pp. 2283-2294 ◽  
Author(s):  
T. Tateno ◽  
A. Harsch ◽  
H. P. C. Robinson
Keyword(s):  
Somatosensory Cortex ◽  
Low Frequency ◽  
Firing Frequency ◽  
Spike Generation ◽  
Low Frequencies ◽  
Subthreshold Oscillations ◽  
Wide Range ◽  
Rat Somatosensory Cortex

Neurons and dynamical models of spike generation display two different types of threshold behavior, with steady current stimulation: type 1 [the firing frequency vs. current ( f– I) relationship is continuous at threshold) and type 2 (discontinuous f– I)]. The dynamics at threshold can have profound effects on the encoding of input as spikes, the sensitivity of spike generation to input noise, and the coherence of population firing. We have examined the f– I and frequency–conductance ( f– g) relationships of cells in layer 2/3 of slices of young (15–21 DIV) rat somatosensory cortex, focusing in detail on the nature of the threshold. Using white-noise stimulation, we also measured firing frequency and interspike interval variability as a function of noise amplitude. Regular-spiking (RS) pyramidal neurons show a type 1 threshold, consistent with their well-known ability to fire regularly at very low frequencies. In fast-spiking (FS) inhibitory interneurons, although regular firing is supported over a wide range of frequencies, there is a clear discontinuity in their f– I relationship at threshold (type 2), which has not previously been highlighted. FS neurons are unable to support maintained periodic firing below a critical frequency fc, in the range of 10 to 30 Hz. Very close to threshold, FS cells switch irregularly between bursts of periodic firing and subthreshold oscillations. These characteristics mean that the dynamics of RS neurons are well suited to encoding inputs into low-frequency firing rates, whereas the dynamics of FS neurons are suited to maintaining and quickly synchronizing to gamma and higher-frequency input.

Type 2 Diabetes Overtakes Type 1 in Hispanic Girls

2008 ◽  
Vol 38 (15) ◽  
pp. 18
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Type 2 Diabetes

Molecular analysis of FVIII gene in severe HA patients of Costa Rica

2010 ◽  
Vol 30 (S 01) ◽  
pp. S150-S152
Author(s):  
G. Jiménez-Cruz ◽  
M. Mendez ◽  
P. Chaverri ◽  
P. Alvarado ◽  
W. Schröder ◽  
...  
Keyword(s):  
Factor Viii ◽  
Coagulation Factor ◽  
Costa Rican ◽  
Factor Viii Gene ◽  
Intron 22 Inversion ◽  
Intron 1 ◽  
Polymerase Chain ◽  
Inversion Analysis

SummaryHaemophilia A (HA) is X-chromosome linked bleeding disorders caused by deficiency of the coagulation factor VIII (FVIII). It is caused by FVIII gene intron 22 inversion (Inv22) in approximately 45% and by intron 1 inversion (Inv1) in 5% of the patients. Both inversions occur as a result of intrachromosomal recombination between homologous regions, in intron 1 or 22 and their extragenic copy located telomeric to the FVIII gene. The aim of this study was to analyze the presence of these mutations in 25 HA Costa Rican families. Patients, methods: We studied 34 HA patients and 110 unrelated obligate members and possible carriers for the presence of Inv22or Inv1. Standard analyses of the factor VIII gene were used incl. Southern blot and long-range polymerase chain reaction for inversion analysis. Results: We found altered Inv22 restriction profiles in 21 patients and 37 carriers. It was found type 1 and type 2 of the inversion of Inv22. During the screening for Inv1 among the HA patient, who were Inv22 negative, we did not found this mutation. Discussion: Our data highlight the importance of the analysis of Inv22 for their association with development of inhibitors in the HA patients and we are continuous searching of Inv1 mutation. This knowledge represents a step for genetic counseling and prevention of the inhibitor development.

Polymorphisms of the Plasminogen Activator Inhibitor- 1 Gene in Type 1 and Type 2 Diabetes, and in Patients with Diabetic Retinopathy

1994 ◽  
Vol 71 (06) ◽  
pp. 731-736 ◽  
Author(s):  
M W Mansfield ◽  
M H Stickland ◽  
A M Carter ◽  
P J Grant
Keyword(s):  
Diabetic Retinopathy ◽  
Plasminogen Activator Inhibitor ◽  
Allelic Frequency ◽  
Repeat Sequence ◽  
Dinucleotide Repeat ◽  
Plasminogen Activator Inhibitor 1 ◽  
The Difference ◽  
Pai 1

SummaryTo identify whether genotype contributes to the difference in PAI-1 levels in type 1 and type 2 diabetic subjects and whether genotype relates to the development of retinopathy, a Hind III restriction fragment length polymorphism and two dinucleotide repeat polymorphisms were studied. In 519 Caucasian diabetic subjects (192 type 1, 327 type 2) and 123 Caucasian control subjects there were no differences in the frequency of the Hind III restriction alleles (type 1 vs type 2 vs control: allele 1 0.397 vs 0.420 vs 0.448; allele 2 0.603 vs 0.580 vs 0.552) nor in the allelic frequency at either dinucleotide repeat sequence. In 86 subjects with no retinopathy at 15 years or more from diagnosis of diabetes and 190 subjects with diabetic retinopathy there was no difference in the frequency of Hind III restriction alleles (retinopathy present vs retinopathy absent: allele 1 0.400 vs 0.467; allele 2 0.600 vs 0.533) nor in the allelic frequencies at either dinucleotide repeat sequence. The results indicate that there is no or minimal influence of the PAI-1 gene on either PAI-1 levels or the development of diabetic retinopathy in patients with diabetes mellitus.

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