scholarly journals Genome-wide linkage scan for contraction velocity characteristics of knee musculature in the Leuven Genes for Muscular Strength Study

2008 ◽  
Vol 35 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Gunther De Mars ◽  
An Windelinckx ◽  
Wim Huygens ◽  
Maarten W. Peeters ◽  
Gaston P. Beunen ◽  
...  
Keyword(s):  
Velocity Ratio ◽  
Protective Role ◽  
Linkage Study ◽  
Knee Extensors ◽  
Genome Wide ◽  
A Genome ◽  
Extensor Muscles ◽  
Velocity Relationship ◽  
Relationship Of ◽  
Knee Flexors

The torque-velocity relationship is known to be affected by ageing, decreasing its protective role in the prevention of falls. Interindividual variability in this torque-velocity relationship is partly determined by genetic factors (h2: 44–67%). As a first attempt, this genome-wide linkage study aimed to identify chromosomal regions linked to the torque-velocity relationship of the knee flexors and extensors. A selection of 283 informative male siblings (17–36 yr), belonging to 105 families, was used to conduct a genome-wide SNP-based (Illumina Linkage IVb panel) multipoint linkage analysis for the torque-velocity relationship of the knee flexors and extensors. The strongest evidence for linkage was found at 15q23 for the torque-velocity slope of the knee extensors (TVSE). Other interesting linkage regions with LOD scores >2 were found at 7p12.3 [logarithm of the odds ratio (LOD) = 2.03, P = 0.0011] for the torque-velocity ratio of the knee flexors (TVRF), at 2q14.3 (LOD = 2.25, P = 0.0006) for TVSE, and at 4p14 and 18q23 for the torque-velocity ratio of the knee extensors TVRE (LOD = 2.23 and 2.08; P = 0.0007 and 0.001, respectively). We conclude that many small contributing genes are involved in causing variation in the torque-velocity relationship of the knee flexor and extensor muscles. Several earlier reported candidate genes for muscle strength and muscle mass and new candidates are harbored within or in close vicinity of the linkage regions reported in the present study.

scholarly journals A genome wide linkage study of obesity as secondary effect of antipsychotics in multigenerational families of eastern Quebec affected by psychoses

2004 ◽  
Vol 9 (12) ◽  
pp. 1067-1074 ◽  
Author(s):  
Y C Chagnon ◽  
C Mérette ◽  
R H Bouchard ◽  
C Émond ◽  
M-A Roy ◽  
...  
Keyword(s):  
Linkage Study ◽  
Secondary Effect ◽  
Multigenerational Families ◽  
Genome Wide ◽  
A Genome

Training-induced alterations of the in vivo force-velocity relationship of human muscle

1981 ◽  
Vol 51 (3) ◽  
pp. 750-754 ◽  
Author(s):  
V. J. Caiozzo ◽  
J. J. Perrine ◽  
V. R. Edgerton
Keyword(s):  
Training Group ◽  
Knee Extension ◽  
Knee Extensors ◽  
Velocity Relationship ◽  
Slow Velocity ◽  
Group A ◽  
Force Velocity ◽  
Group B ◽  
Relationship Of

Seventeen male and female subjects (ages 20–38 yr) were tested pre- and posttraining for maximal knee extension torque at seven specific velocities (0, 0.84, 1.68, 2.51, 3.35, 4.19, and 5.03 rad . s-1) with an isokinetic dynamometer. Maximal knee extension torques were recorded at a specific joint angle (0.52 rad below the horizontal plane) for all test speeds. Subjects were randomly assigned to one of three experimental groups: group A, control, n = 7; group B, training at 1.68 rad . s-1, n = 5; or group C, training at 4.19 rad . s-1, n = 5. Subjects trained the knee extensors by performing two sets of 10 single maximal voluntary efforts three times a week for 4 wk. Before training, each training group exhibited a leveling-off of muscular tension in the slow velocity-high force region of the in vivo force-velocity relationship. Training at 1.68 rad . s-1 resulted in significant (P less than 0.05) improvements at all velocities except for 5.03 rad . s-1 and markedly affected the leveling-off in the slow velocity-high force region. Training at 4.19 rad . s-1 did not affect the leveling-off phenomenon but brought about significant improvements (P less than 0.05) at velocities of 2.51, 3.35, and 4.19 rad . s-1. The changes seen in the leveling-off phenomenon suggest that training at 1.68 rad . s-1 might have brought about an enhancement of motoneuron activation.

scholarly journals Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype

2007 ◽  
Vol 13 (1) ◽  
pp. 84-89 ◽  
Author(s):  
C M Middeldorp ◽  
J-J Hottenga ◽  
P E Slagboom ◽  
P F Sullivan ◽  
E J C de Geus ◽  
...  
Keyword(s):  
Linkage Study ◽  
Chromosome 14 ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide linkage study of GAW15 gene expression data

2007 ◽  
Vol 1 (Suppl 1) ◽  
pp. S87 ◽  
Author(s):  
Donghui Kan ◽  
Richard Cooper ◽  
Xiaofeng Zhu
Keyword(s):  
Gene Expression ◽  
Gene Expression Data ◽  
Linkage Study ◽  
Expression Data ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide protein phylogenies for four African cichlid species

2017 ◽  
Author(s):  
Ajay Ramakrishnan Varadarajan ◽  
Rohini Mopuri ◽  
J. Todd Streelman ◽  
Patrick T. McGrath
Keyword(s):  
Protein Function ◽  
Evolutionary Relationship ◽  
Trait Variation ◽  
Cichlid Species ◽  
Genome Wide ◽  
A Genome ◽  
History Of ◽  
Astatotilapia Burtoni ◽  
African Cichlids ◽  
Relationship Of

ABSTRACTBackgroundThe thousands of species of closely related cichlid fishes in the great lakes of East Africa are a powerful model for understanding speciation and the genetic basis of trait variation. Recently, the genomes of five species of African cichlids representing five distinct lineages were sequenced and used to predict protein products at a genome-wide level. Here we characterize the evolutionary relationship of each cichlid protein to previously sequenced animal species.ResultsWe used the Treefam database, a set of preexisting protein phylogenies built using 109 previously sequenced genomes, to identify Treefam families for each protein annotated from four cichlid species: Metriaclima zebra, Astatotilapia burtoni, Pundamilia nyererei and Neolamporologus brichardi. For each of these Treefam families, we built new protein phylogenies containing each of the cichlid protein hits. Using these new phylogenies we identified the evolutionary relationship of each cichlid protein to its nearest human and zebrafish protein. This data is available either through download or through a webserver we have implemented.ConclusionThese phylogenies will be useful for any cichlid researchers trying to predict biological and protein function for a given cichlid gene, understanding the evolutionary history of a given cichlid gene, identifying recently duplicated cichlid genes, or performing genome-wide analysis in cichlids that relies on using databases generated from other species.

A genome-wide linkage study in families with major depression and co-morbid unexplained swelling

2008 ◽  
Vol 147B (3) ◽  
pp. 356-362
Author(s):  
Carl A. Anderson ◽  
Alan Maclean ◽  
Matthew G. Dunnigan ◽  
Anthony J. Pelosi ◽  
Valerie Murray ◽  
...  
Keyword(s):  
Major Depression ◽  
Linkage Study ◽  
Genome Wide ◽  
A Genome
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