Form and Function: Impulse Propagation in Designer Cultures of Cardiomyocytes

Physiology ◽  
1997 ◽  
Vol 12 (4) ◽  
pp. 171-177 ◽  
Author(s):  
S Rohr ◽  
JP Kucera ◽  
AG Kleber

The architecture of the cellular network forming the myocardium is an important determinant of the characteristics of impulse propagation. This article describes an experimental approach permitting the systematic study of this structure-function relationship, which is based on optical micromapping of electrical activity in cardiac cell cultures with a defined two-dimensional geometry.

2011 ◽  
Vol 368-373 ◽  
pp. 3732-3736
Author(s):  
Xiao Ling Dai ◽  
Hua Li Zhang

Due to the advance of computer science, we now have more powerful tools to digitize and analyze the complex system of urban form, which was difficult for describing and exploring previously. Space syntax theory and method is one of these tools which can help to clarify the social logic of space quantitatively. By this tool, this study examined the urban transformation process of the London area of Soho in the last 100 years, aiming at articulating the intriguing form and function relationship. This study proposed that although the spatial change and social change are in different speed, their changing process still intertwined and interacted with each other.


Author(s):  
Patricia G. Arscott ◽  
Gil Lee ◽  
Victor A. Bloomfield ◽  
D. Fennell Evans

STM is one of the most promising techniques available for visualizing the fine details of biomolecular structure. It has been used to map the surface topography of inorganic materials in atomic dimensions, and thus has the resolving power not only to determine the conformation of small molecules but to distinguish site-specific features within a molecule. That level of detail is of critical importance in understanding the relationship between form and function in biological systems. The size, shape, and accessibility of molecular structures can be determined much more accurately by STM than by electron microscopy since no staining, shadowing or labeling with heavy metals is required, and there is no exposure to damaging radiation by electrons. Crystallography and most other physical techniques do not give information about individual molecules.We have obtained striking images of DNA and RNA, using calf thymus DNA and two synthetic polynucleotides, poly(dG-me5dC)·poly(dG-me5dC) and poly(rA)·poly(rU).


2011 ◽  
Author(s):  
Scott Fluke ◽  
Russell J. Webster ◽  
Donald A. Saucier

2013 ◽  
Author(s):  
Joshua Wilt ◽  
William Revelle

Author(s):  
Barbara Schönig

Going along with the end of the “golden age” of the welfare state, the fordist paradigm of social housing has been considerably transformed. From the 1980s onwards, a new paradigm of social housing has been shaped in Germany in terms of provision, institutional organization and design. This transformation can be interpreted as a result of the interplay between the transformation of national welfare state and housing policies, the implementation of entrepreneurial urban policies and a shift in architectural and urban development models. Using an integrated approach to understand form and function of social housing, the paper characterizes the new paradigm established and nevertheless interprets it within the continuity of the specific German welfare resp. housing regime, the “German social housing market economy”.


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