Immune checkpoint-targeted antibodies: a room for dose and schedule optimization?

Anti-CTLA-4 and anti-PD-1/PD-L1 immune checkpoint inhibitors are therapeutic monoclonal antibodies that do not target cancer cells but are designed to reactivate or promote antitumor immunity. Dosing and scheduling of these biologics were established according to conventional drug development models, even though the determination of a maximum tolerated dose in the clinic could only be defined for anti-CTLA-4. Given the pharmacology of these monoclonal antibodies, their high interpatient pharmacokinetic variability, the actual clinical benefit as monotherapy that is observed only in a specific subset of patients, and the substantial cost of these treatments, a number of questions arise regarding the selected dose and the dosing interval. This review aims to outline the development of these immunotherapies and considers optimization options that could be used in clinical practice.

PENGEMBANGAN ALAT PERAGA PEMELAJARAN MATEMATIKA KELAS III SD BERBASIS METODE MONTESSORI DI SD ISLAM ASSALAM CURUG KABUPATEN TANGERANG

PENGEMBANGAN ALAT PERAGA PEMBELAJARAN MATEMATIKA KELAS III SD BERBASIS METODE MONTESSORI DI SD ISLAM ASSALAM CURUG KABUPATEN TANGERANG Fita Nur Septiana1, Mawardi, S.Si., M.Pd2, Najib Hasan, M.Pd3 1Program Studi Pendidikan Guru Sekolah Dasar 1,2 Universitas Muhammadiyah Tangerang E-mail : [email protected](1) [email protected] (2) [email protected] (3) Abstract : the purpose of this study is to develop model multiplication boards based on montessori methods in math class III . The research USE addie's version of development models. The population in this study is 3rd graders a islamic elementary school assalam curug. The techniques in drawing samples in the study use the small group test of 10 students and the large group test of 16 students. The instruments used include interviews, angkets and pre-test questions. The results of this development study met the "worthy" criteria of a media expert of 4,3 with the "very worthy" criteria and the angket research of a 4,2 materials expert and met the "very worthy" criteria and met the "very worthy" criteria and met the "very worthy" criteria and met the criteria of a 3,9 sebersar scholar and met the "worthy" criteria. At a small scale test assessment involving 10 class III students results from a 4,4 presentation and large-scale trial results from 4,3 propelled, thus the "very good" criteria. "Worthy," practical and effective "for use in math class operations materials calculate multiplication to class 3 theme 2 subtheme. Keywords: ADDIE, multiplication board, math, Research and Development (R&D

Destination management in a post-covid environment

PurposeThis paper seeks to reflect on the impacts of the pandemic on the management of tourist destinations, discussing the role of destination-management organizations in the tourism development model, as well as the challenges that these organizations must address to ensure an effective construction of a more sustainable and competitive tourism.Design/methodology/approachThe methodology is based on a literature review linking destination management with pandemic and post-pandemic responses.FindingsThe COVID-19 pandemic represents an unprecedent shock to the tourism industry's growth model since World War II, challenging tourism stakeholders (destinations and companies) with several threats and opportunities to their future competitiveness. In addition to the massive impacts in terms of business development, the abrupt reduction of tourism demand and the significative loss of jobs, the pandemic also caused significant disruption in terms of destination-management models. In less than four months, the focus of Governments and Destination Management Organizations shifted from defining development models compatible with improving the quality of life of residents due to the emergence of the so-called overtourism phenomenon, to the urgent need to support the industry's survival, to preserve jobs and ensure conditions of safety for tourists and workers.Originality/valueDemonstrates the need for a profound change in the paradigm of destination management so that the sector is prepared to face future shocks. It also proposes further discussion on the role of destination management in the recovery process of the tourism sector in global terms, given the challenges that these organizations face. The article also considers the ways in which destination management can be a fundamental tool in the process of building a more inclusive, sustainable and competitive future.

Methods for estimating and modelling spruce budworm development rates at constant temperatures

We describe an experimental protocol for measuring the response of spruce budworm postdiapause larval development to temperature. This protocol is specifically designed to include measurements of development near their upper and lower thermal thresholds. The application of this protocol to a laboratory colony allowed for the first experimental evidence that spruce budworm larval development occurs at temperatures as low as 5 °C and as high as 35 °C, and it provides data to fit stage-specific development models. Our protocol is also designed to minimise mortality near the thermal development thresholds, thus allowing for multigenerational studies. We observed developmental plasticity in larvae reared at constant temperatures, particularly the occurrence of up to 42% of some individuals requiring only five instars to complete development compared to the expected six instars. The occurrence exhibited no clear relation to temperature. Although this protocol is specifically designed for spruce budworm, it provides a template for the study of other species’ developmental responses to temperature.

Strategic Approaches to Planning School Development and Improving Educational Outcomes

The article presents an example of strategic planning of school development in order to improve educational results. The author provides arguments and justifications for the choice of specific strategic approaches from understanding the categories of "school performance", "development factors", "management team", "social capital", "innovative activity" to researching the potential of the school, specific management decisions, demonstrating the structure and content developed development models. The material of the article reflects in detail the strategy of planning the educational process in a particular school in terms of development. The model of the innovative project "Educational Navigator" is described. A model of intraschool education quality assessment is presented. The article provides examples of the results of the study.

University–industry collaboration in curriculum design and delivery: A model and its application in manufacturing engineering courses

The advantages and importance of university–industry collaboration, particularly in curriculum design and delivery, are well-known. However, although curriculum development models are available in the literature, very few are sufficiently concrete to be applicable in practice or are generalizable beyond their discipline of origin. In this paper, a co-operative model based on the Plan–Do–Study–Act cycle is presented and described. An example of its application in the curriculum design of two courses in welding within a Manufacturing Engineering Master’s program is detailed. The model was found successful based on the evaluation of the courses by students, teachers, and the industrial representatives involved. Therefore, it proved to be an effective tool for bridging the gap between industrial needs and academia in the field of Manufacturing Engineering education. At the same time, the methodology is generalizable and is applicable to any field of education.

Pengembangan Media Pembelajaran Bahasa Inggris yang Praktis dan Efektif Menggunakan Moodle

The method of delivering learning by orally as well as giving a note in the form of copy or note, is less successful in time and is not maximally obtained by a student. The purpose of this research is to produce practical and effective learning media used by teacher and student at vocational high school. Web-based learning media using model 3.11.3+, which is applied to the domain and hosting. The type of this research is R&D (research & development), and the product development models are 4D; define, design, develop and disseminate. The instruments used are questionnaire, material, practically and English questions. The subjects of research are teacher and student of SMK Pratama Padang. Data analysis techniques are product validity testing, practical analysis technique and product effectiveness analysis technique. The levels of practicality of the product are 85 (teacher’s respondent) in the practical category and 81.99 (student’s respondent) in the very practical category. The level of product effectiveness based on the gain score reached 0.45, in the medium category.

Development model of rock relief on thick horizontal and gently sloping rock strata exposed to rain

Due to various factors influencing diverse rocks, karst phenomena take unique shapes that are most often reflected in the rock relief. Through a series of different developmental factors, new factors first gradually transform the traces of old formations and over time, if they are distinct enough, they can replace them with completely new ones. In places old forms are reflected in the formation of a new rock relief only indirectly. The rock relief of karst phenomena, in this case karren, also develops under the influence of a single factor. Developmentally, rock forms, due to dissection of the surface and lasting of development, often in several layers merge into one another. A development model enables us to discover the overall development of the formation of the selected part of the rocky karst surface. The individual rock forms which have merged into the rock relief represent just one stage of development. Good knowledge of the overall development enables us to discern the development so far and predict future development. A number of development models can be discerned. One of the basic models reveals the manner of the rain-induced formation and development of horizontal and gently sloping carbonate rock strata into karren and stone forests, especially after the disintegration of the upper (thinner) rock strata and the denudation and shaping of the bottom strata. It reveals many characteristics of rock formation, from the sheet flow to the formation of rain flutes, their merging into rain channels and the development of funnel-like notches; that is, developmental transition of rock forms and rock relief in the overall development from the flat surface to its dissection into peaks.

Collective and Individual Factors in the Development of Creative Ideas in Art: The Perspective of Film Directors

The study focuses on the question if and how it is possible to balance the freedom of developing artist’s individual creative idea and the societal demand for art defined in a concrete political context. The theoretical basis for the article is formed by research approaches grounded on sociology of creativity and social psychology. The object of the case study is film directors who had obtained funding for the production and dissemination of their films within the funding program ‘Latvian Films for Latvia’s Centenary’ (2016–2018). The experience of film directors (N 16) was examined by using in-depth interviews and transcriptions analysed in accordance with qualitative methodology. The study identified two contingent levels of creativity inspiration – the individual and the societal or collective level. The authors identify several development models of the film directors’ creative ideas, three of which are dominant: the independent outsider who stresses individual, seed-incident based creativity factors independent of the Latvian Centenary program; the independent idealist who stresses both individual and collective factors, independent of the Latvian Centenary program; the conforming patriot who stresses collective creativity factors that stem from the Latvian Centenary program. The view represented in the film directors’ interviews has in common the assumption that the Latvian Centenary call had a positive influence on the film ideas, allowing the development of the artistic vision and conceptualising the framework for the expression of their ideas. The directors emphasise that there was no intentional configuration of the film creative ideas by formally adjusting them to the demand, thus circumventing the barriers of social field’s gatekeepers. In many cases the idea had been developed long before the film idea call. Most directors admitted that the goal of the Centenary call appeared important to them both in terms of the state, and on the social and personal level.

Addressing Economic Fragmentation: Modelling Regional Gambling Tourism In The Context Of Social Fields Theory

The trend in development is going from slow withdrawal from mass tourism to a growing demand for small-scale local, customer-tailored travel experiences. The main question is balancing two main tourism development models: mass tourism connected to gambling, on the one hand, and customer-oriented local experience on the other. How should policymakers proceed in shaping the development of policies supporting both models? We discuss case studies proposed to build a qualitative multi-criteria decision model to evaluate the appropriateness of the development of new models encompassing the two mentioned. Therefore, the multi-criteria decision method DEX and the DEXi software tool are practical options for decision support in gambling tourism management. This study quickly analyses basic concepts of the DEX method and possible applications on actual life decisions and valuation problems.