Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?

Physiology ◽  
2002 ◽  
Vol 17 (1) ◽  
pp. 17-21 ◽  
Author(s):  
Håkan Westerblad ◽  
David G. Allen ◽  
Jan Lännergren
Keyword(s):  
Skeletal Muscle ◽  
Lactic Acid ◽  
Muscle Fatigue ◽  
Muscle Function ◽  
Inorganic Phosphate ◽  
Creatine Phosphate ◽  
Intracellular Acidosis ◽  
Skeletal Muscle Fatigue ◽  
Mammalian Muscle ◽  
Acid Accumulation

Intracellular acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue. Recent studies on mammalian muscle, however, show little direct effect of acidosis on muscle function at physiological temperatures. Instead, inorganic phosphate, which increases during fatigue due to breakdown of creatine phosphate, appears to be a major cause of muscle fatigue.

scholarly journals Lactic acid restores skeletal muscle force in an in vitro fatigue model: are voltage-gated chloride channels involved?

2012 ◽  
Vol 302 (7) ◽  
pp. C1019-C1025 ◽  
Author(s):  
Oliver Bandschapp ◽  
Charles L. Soule ◽  
Paul A. Iaizzo
Keyword(s):  
Skeletal Muscle ◽  
Lactic Acid ◽  
Muscle Fatigue ◽  
Muscle Cell ◽  
Chloride Channel ◽  
Chloride Channels ◽  
Intracellular Acidosis ◽  
Voltage Gated ◽  
Muscle Contractile

High interstitial K+ concentration ([K+]) has been reported to impede normal propagation of electrical impulses along the muscle cell membrane (sarcolemma) and then also into the transverse tubule system; this is one considered underlying mechanism associated with the development of muscle fatigue. Interestingly, the extracellular buildup of lactic acid, once considered an additional cause for muscle fatigue, was recently shown to have force-restoring effects in such conditions. Specifically, it was proposed that elevated lactic acid (and intracellular acidosis) may lead to inhibition of voltage-gated chloride channels, thereby reestablishing better excitability of the muscle cell sarcolemma. In the present study, using an in vitro muscle contractile experimental setup to study functionally viable rectus abdominis muscle preparations obtained from normal swine, we examined the effects of 20 mM lactic acid and 512 μM 9-anthracenecarboxylic acid (9-AC; a voltage-gated chloride channel blocker) on the force recovery of K+-depressed (10 mM K+) twitch forces. We observed a similar muscle contractile restoration after both treatments. Interestingly, at elevated [K+], myotonia (i.e., hyperexcitability or afterdepolarizations), usually present in skeletal muscle with inherent or induced chloride channel dysfunctions, was not observed in the presence of either lactic acid or 9-AC. In part, these data confirm previous studies showing a force-restoring effect of lactic acid in high-[K+] conditions. In addition, we observed similar restorative effects of lactic acid and 9-AC, implicating a beneficial mechanism via voltage-gated chloride channel modulation.

Skeletal muscle fatigue does not affect shooting accuracy of handball players

2019 ◽  
Vol 27 (4) ◽  
pp. 253-259
Author(s):  
Beyza Akyüz ◽  
Pınar Arpınar Avşar ◽  
Murat Bilge ◽  
Gökhan Deliceoğlu ◽  
Feza Korkusuz
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fatigue ◽  
Skeletal Muscle Fatigue

scholarly journals Fourteen days of smoking cessation improves muscle fatigue resistance and reverses markers of systemic inflammation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mohammad Z. Darabseh ◽  
Thomas M. Maden-Wilkinson ◽  
George Welbourne ◽  
Rob C. I. Wüst ◽  
Nessar Ahmed ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Smoking Cessation ◽  
Muscle Fatigue ◽  
Fatigue Resistance ◽  
Systemic Inflammation ◽  
Muscle Function ◽  
Low Grade ◽  
Skeletal Muscle Function ◽  
Tnf Α

AbstractCigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Peak expiratory flow (p = 0.004) and forced expiratory volume in 1 s/forced vital capacity (p = 0.037) were lower in smokers compared to non-smokers but did not change significantly after smoking cessation. Smoking cessation increased skeletal muscle fatigue resistance (p < 0.001). Haemoglobin content, haematocrit, carboxyhaemoglobin, total AGEs, malondialdehyde, TNF-α, IL-2, IL-4, IL-6 and IL-10 (p < 0.05) levels were higher, and total antioxidant status (TAS), IL-12p70 and eosinophil numbers were lower (p < 0.05) in smokers. IL-4, IL-6, IL-10 and IL-12p70 had returned towards levels seen in non-smokers after 14 days smoking cessation (p < 0.05), and IL-2 and TNF-α showed a similar pattern but had not yet fully returned to levels seen in non-smokers. Haemoglobin, haematocrit, eosinophil count, AGEs, MDA and TAS did not significantly change with smoking cessation. Two weeks of smoking cessation was accompanied with an improved muscle fatigue resistance and a reduction in low-grade systemic inflammation in smokers.

scholarly journals Potential cellular and energetic mechanisms for age‐related differences in skeletal muscle fatigue

2018 ◽  
Vol 597 (2) ◽  
pp. 373-374
Author(s):  
Aurora D. Foster ◽  
Liam F. Fitzgerald ◽  
Miles F. Bartlett ◽  
Chad R. Straight
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fatigue ◽  
Skeletal Muscle Fatigue ◽  
Age Related

Photobiomodulation (PBM) therapy at 904 nm mitigates effects of exercise-induced skeletal muscle fatigue in young women

2018 ◽  
Vol 33 (6) ◽  
pp. 1197-1205 ◽  
Author(s):  
Renata Luri Toma ◽  
Murilo Xavier Oliveira ◽  
Ana Cláudia Muniz Renno ◽  
E-Liisa Laakso
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fatigue ◽  
Young Women ◽  
Skeletal Muscle Fatigue ◽  
Exercise Induced
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