scholarly journals Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System

2017 ◽  
Vol 97 (2) ◽  
pp. 839-887 ◽  
Author(s):  
Josep Dalmau ◽  
Christian Geis ◽  
Francesc Graus
Keyword(s):  
Nmda Receptor ◽  
Cell Surface ◽  
Protein Interactions ◽  
Synapse Formation ◽  
Gabab Receptor ◽  
Neurological Diseases ◽  
Neuronal Cell ◽  
Surface Proteins ◽  
Synaptic Proteins ◽  
Neuronal Proteins

Investigations in the last 10 years have revealed a new category of neurological diseases mediated by antibodies against cell surface and synaptic proteins. There are currently 16 such diseases all characterized by autoantibodies against neuronal proteins involved in synaptic signaling and plasticity. In clinical practice these findings have changed the diagnostic and treatment approach to potentially lethal, but now treatable, neurological and psychiatric syndromes previously considered idiopathic or not even suspected to be immune-mediated. Studies show that patients' antibodies can impair the surface dynamics of the target receptors eliminating them from synapses (e.g., NMDA receptor), block the function of the antigens without changing their synaptic density (e.g., GABAb receptor), interfere with synaptic protein-protein interactions (LGI1, Caspr2), alter synapse formation (e.g., neurexin-3α), or by unclear mechanisms associate to a new form of tauopathy (IgLON5). Here we first trace the process of discovery of these diseases, describing the triggers and symptoms related to each autoantigen, and then review in detail the structural and functional alterations caused by the autoantibodies with special emphasis in those (NMDA receptor, amphiphysin) that have been modeled in animals.

scholarly journals Teneurins: A Novel Family of Neuronal Cell Surface Proteins in Vertebrates, Homologous to the Drosophila Pair-Rule Gene Product Ten-m

1999 ◽  
Vol 216 (1) ◽  
pp. 195-209 ◽  
Author(s):  
Beatrix P. Rubin ◽  
Richard P. Tucker ◽  
Doris Martin ◽  
Ruth Chiquet-Ehrismann
Keyword(s):  
Cell Surface ◽  
Gene Product ◽  
Neuronal Cell ◽  
Surface Proteins ◽  
Cell Surface Proteins ◽  
Pair Rule Gene ◽  
Pair Rule

Expression patterns of neuronal cell surface proteins plexin in developing mouse

1994 ◽  
Vol 19 ◽  
pp. S126
Author(s):  
Yasunori Murakami ◽  
Toshiki Kameyama ◽  
Atsushi Kawakami ◽  
Takashi Kitsukawa ◽  
Hajime Fujisawa
Keyword(s):  
Cell Surface ◽  
Expression Patterns ◽  
Neuronal Cell ◽  
Surface Proteins ◽  
Cell Surface Proteins

scholarly journals Prediction of the Secretome and the Surfaceome: A Strategy to Decipher the Crosstalk between Adipose Tissue and Muscle during Fetal Growth

2020 ◽  
Vol 21 (12) ◽  
pp. 4375
Author(s):  
Muriel Bonnet ◽  
Nicolas Kaspric ◽  
Kimberly Vonnahme ◽  
Didier Viala ◽  
Christophe Chambon ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Cell Surface ◽  
Fetal Growth ◽  
Protein Interactions ◽  
Cell Types ◽  
Surface Proteins ◽  
Protein Protein Interactions ◽  
Cell Surface Proteins ◽  
Bovine Fetuses ◽  
Muscular Tissues

Crosstalk between adipose and muscular tissues is hypothesized to regulate the number of muscular and adipose cells during fetal growth, with post-natal consequences on lean and fat masses. Such crosstalk largely remains, however, to be described. We hypothesized that a characterization of the proteomes of adipose and muscular tissues from bovine fetuses may enhance the understanding of the crosstalk between these tissues through the prediction of their secretomes and surfaceomes. Proteomic experiments have identified 751 and 514 proteins in fetal adipose tissue and muscle. These are mainly involved in the regulation of cell proliferation or differentiation, but also in pathways such as apoptosis, Wnt signalling, or cytokine-mediated signalling. Of the identified proteins, 51 adipokines, 11 myokines, and 37 adipomyokines were predicted, together with 26 adipose and 13 muscular cell surface proteins. Analysis of protein–protein interactions suggested 13 links between secreted and cell surface proteins that may contribute to the adipose–muscular crosstalk. Of these, an interaction between the adipokine plasminogen and the muscular cell surface alpha-enolase may regulate the fetal myogenesis. The in silico secretome and surfaceome analyzed herein exemplify a powerful strategy to enhance the elucidation of the crosstalk between cell types or tissues.

scholarly journals Encephalitis and antibodies to synaptic and neuronal cell surface proteins

Neurology ◽  
2011 ◽  
Vol 77 (2) ◽  
pp. 179-189 ◽  
Author(s):  
E. Lancaster ◽  
E. Martinez-Hernandez ◽  
J. Dalmau
Keyword(s):  
Cell Surface ◽  
Neuronal Cell ◽  
Surface Proteins ◽  
Cell Surface Proteins

scholarly journals Surfaceome dynamics during neuronal development and synaptic plasticity reveal system-wide surfaceome reorganization independent of global proteostasis

2019 ◽  
Author(s):  
Marc van Oostrum ◽  
Benjamin Campbell ◽  
Maik Müller ◽  
Patrick G. A. Pedrioli ◽  
Shiva K. Tyagarajan ◽  
...  
Keyword(s):  
Total Protein ◽  
Neuronal Development ◽  
Synapse Formation ◽  
Surface Protein ◽  
Long Term Potentiation ◽  
Surface Proteins ◽  
Synaptic Proteins ◽  
Functional Requirements ◽  
Dynamic Surface ◽  
Brain Transcriptome

Neurons are highly compartmentalized cells with tightly controlled subcellular protein organization. While broad brain transcriptome, connectome and global proteome maps are being generated, system-wide analysis of temporal protein dynamics at the subcellular level are currently lacking for neuronal development and synapse formation. We performed a temporally-resolved surfaceome analysis of developing primary neuron cultures to a depth of 1000 bona fide surface proteins and reveal dynamic surface protein clusters that reflect the functional requirements during distinct stages of neuronal development. Moreover, our data shows that synaptic proteins are globally trafficked to the surface prior to synapse formation. Direct comparison of surface and total protein pools demonstrates that, depending on the time scale, surface abundance changes can correlate or differ from total protein abundance. The uncoupling of surface and total abundance changes has direct functional implications as shown in the context of synaptic vesicle transport. To demonstrate the utility of our approach we analyzed the surfaceome modulation in response to homeostatic synaptic scaling and found dynamic remodeling of the neuronal surface, which was largely independent of global proteostasis, indicative of wide-spread regulation on the level of surface trafficking. Finally, we present a quantitative analysis of the neuronal surface during early-phase long-term potentiation (LTP) and reveal fast externalization of diverse classes of surface proteins beyond the AMPA receptor, providing new insights into the requirement of exocytosis for LTP. Our resource and finding of organizational principles highlight the importance of subcellular resolution for systems-level understanding of cellular processes, which are typically masked by broad omics-style approaches.

scholarly journals Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.

1994 ◽  
Vol 269 (16) ◽  
pp. 11987-11992 ◽  
Author(s):  
Y.A. Ushkaryov ◽  
Y. Hata ◽  
K. Ichtchenko ◽  
C. Moomaw ◽  
S. Afendis ◽  
...  
Keyword(s):  
Cell Surface ◽  
Domain Structure ◽  
Neuronal Cell ◽  
Surface Proteins ◽  
Signal Sequences ◽  
Cell Surface Proteins ◽  
Conserved Domain
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