scholarly journals The Value of Alarm Features in Identifying Organic Causes of Dyspepsia

2000 ◽  
Vol 14 (8) ◽  
pp. 713-720 ◽  
Author(s):  
Lone Galmstrup Madsen ◽  
Peter Bytzer
Keyword(s):  
Weight Loss ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Gastrointestinal Disease ◽  
Abdominal Mass ◽  
Gastrointestinal Malignancy ◽  
Ulcer Disease ◽  
Inflammatory Drugs ◽  
Alarm Features ◽  
Upper Gastrointestinal

The unaided clinical diagnosis of dyspepsia is of limited value in separating functional dyspepsia from clinically relevant organic causes of dyspepsia (gastric and esophageal malignancies, peptic ulcer disease and complicated esophagitis). The identification of one or more alarm features, such as weight loss, dysphagia, signs of gastrointestinal bleeding, an abdominal mass or age over 45 years may help identify patients with a higher risk of organic disease. This review summarizes the frequency of alarm symptoms in dyspeptic patients in different settings (such as the community, primary care and specialist clinics). The prevalence of alarm features in patients diagnosed with upper gastrointestinal malignancy or peptic ulcer disease is described. The probability of diagnosing clinically relevant upper gastrointestinal disease in patients presenting with alarm features and other risk factors is discussed. Alarm features such as age, significant weight loss, use of nonsteroidal anti-inflammatory drugs, signs of bleeding and dysphagia may help stratify dyspeptic patients and help optimize the use of endoscopy resources.

scholarly journals Case Report: Peptic ulcer disease following short-term use of nonsteroidal anti-inflammatory drugs in a 3-year-old child

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 419
Author(s):  
Alin Dumitru Ciubotaru ◽  
Carmen-Ecaterina Leferman
Keyword(s):  
Risk Factors ◽  
Peptic Ulcer ◽  
Gastrointestinal Bleeding ◽  
Peptic Ulcer Disease ◽  
Upper Gastrointestinal Bleeding ◽  
Short Term ◽  
Ulcer Disease ◽  
Coffee Ground ◽  
Inflammatory Drugs ◽  
Upper Gastrointestinal

Background: Peptic ulcer disease (PUD) affects 1-2 per 1000 people annually in the USA, the UK and Europe, and occurs less frequently in children than in adults. PUD in children occurs mainly during the second decade of development. Among risk factors, nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used to manage acute febrile illness or pain in healthy children, is rarely reported to lead to PUD and upper gastrointestinal bleeding. Case presentation: We present a rare case of upper gastrointestinal bleeding following a low dose ibuprofen treatment in a 3-year-old female. The patient with a family history of peptic ulcer was admitted for fever, coffee-ground vomiting and abdominal pain. The clinical examination revealed an altered general health status with a distended and mildly tender abdomen moving normally with respiration as well as normal stool. The initial laboratory test indicated anemia with reticulocytosis. During the first hours of hospitalization, the patient had a second episode of coffee-ground vomiting. An upper digestive endoscopy with biopsy was performed in the following six hours revealing a non-bleeding gastric ulcer at 2 cm from pylorus. Helicobacter pylori testing was negative. The patient was treated with a proton pump inhibitor (esomeprazole 10 mg/day) for 2 months. There were no further gastrointestinal symptoms and hemoglobin values returned to normal, indicating resolution of her gastrointestinal bleeding. Conclusion: The short-term utilization of NSAIDs in the appropriate dosage can lead to PUD, and considering the risk factors before administration can lead to an appropriate management.

scholarly journals Case Report: Peptic ulcer disease following short-term use of nonsteroidal anti-inflammatory drugs in a 3-year-old child

F1000Research ◽  
2021 ◽  
Vol 9 ◽  
pp. 419
Author(s):  
Alin Dumitru Ciubotaru ◽  
Carmen-Ecaterina Leferman
Keyword(s):  
Risk Factors ◽  
Peptic Ulcer ◽  
Gastrointestinal Bleeding ◽  
Peptic Ulcer Disease ◽  
Upper Gastrointestinal Bleeding ◽  
Short Term ◽  
Ulcer Disease ◽  
Coffee Ground ◽  
Inflammatory Drugs ◽  
Upper Gastrointestinal

Background: Peptic ulcer disease (PUD) affects 1-2 per 1000 people annually in the USA, the UK and Europe, and occurs less frequently in children than in adults. PUD in children occurs mainly during the second decade of development. Among risk factors, nonsteroidal anti-inflammatory drugs (NSAIDs), commonly used to manage acute febrile illness or pain in healthy children, is rarely reported to lead to PUD and upper gastrointestinal bleeding. Case presentation: We present a rare case of upper gastrointestinal bleeding following a low dose ibuprofen treatment in a 3-year-old female. The patient with a family history of peptic ulcer was admitted for fever, coffee-ground vomiting and abdominal pain. The clinical examination revealed an altered general health status with a distended and mildly tender abdomen moving normally with respiration as well as normal stool. The initial laboratory test indicated anemia with reticulocytosis. During the first hours of hospitalization, the patient had a second episode of coffee-ground vomiting. An upper digestive endoscopy with biopsy was performed in the following six hours revealing a non-bleeding gastric ulcer at 2 cm from pylorus. Helicobacter pylori testing was negative. The patient was treated with a proton pump inhibitor (esomeprazole 10 mg/day) for 2 months. There were no further gastrointestinal symptoms, hemoglobin values returned to normal and the follow-up endoscopy confirmed the healing of the ulcer. Conclusion: The short-term utilization of NSAIDs in the appropriate dosage can lead to PUD, and considering the risk factors before administration can lead to an appropriate management.

scholarly journals Association of Peptic Ulcer Disease with Obesity, Serum Insulin Level and Lipid Profile

2020 ◽  
Author(s):  
Foroogh Forghani ◽  
Mahboube Mirhashemi
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Lipid Profile ◽  
Gastrointestinal Disease ◽  
Serum Insulin ◽  
Insulin Level ◽  
Contributing Factors ◽  
Ulcer Disease ◽  
Significant Difference

Abstract Background: PUD is a common and important type of gastrointestinal disease. Determination of contributing factors for PUD is an important issue for the development of preventive approaches. In this study, the association of Peptic Ulcer Disease with Obesity and Serum Insulin and Lipid Profile was studied.Methods: In this case-control study in Modarres Hospital in Tehran in 2019 among 170 consecutive subjects including 90 patients with PUD and 80 cases without it were enrolled and sampling tools were checklists. Serum Insulin and Lipid Profile and BMI were compared across the groupsResults: The results in this study demonstrated that Serum Insulin and Lipid Profile and BMI had no statistically significant difference between those patients with and without presence of PUD (P > 0.05).Conclusion: This study showed no statistically significant difference between those patients with and without the presence of PUD from points of Serum Insulin and Lipid Profile and BMI.

Not so Goody’s powder

2021 ◽  
Vol 14 (7) ◽  
pp. e242055
Author(s):  
Raja Samir Khan ◽  
Sardar Momin Shah-Khan ◽  
Justin Kupec
Keyword(s):  
Peptic Ulcer ◽  
Adverse Effects ◽  
Gastrointestinal Bleeding ◽  
Peptic Ulcer Disease ◽  
Upper Gastrointestinal Bleeding ◽  
Gastrocolic Fistula ◽  
Over The Counter ◽  
Ulcer Disease ◽  
Upper Gastrointestinal ◽  
Acute Anaemia

Over-the-counter analgesic medications are widely used amongst American adults and are also available in powder forms. Their adverse effects have been well documented in literature. Gastrocolic fistulas as a complication of peptic ulcer disease from analgesic powder usage have been previously unreported. Here, we report a patient with upper gastrointestinal bleeding and acute anaemia secondary to peptic ulcer complicated by gastrocolic fistula in a patient using analgesic powder.

Effects of Ramadan fasting on peptic ulcer disease as diagnosed by upper gastrointestinal endoscopy

2012 ◽  
Vol 13 (4) ◽  
pp. 180-183
Author(s):  
Ali Kagan Gokakin ◽  
Atilla Kurt ◽  
Gunduz Akgol ◽  
Boran Cihat Karakus ◽  
Mustafa Atabey ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Gastrointestinal Endoscopy ◽  
Upper Gastrointestinal Endoscopy ◽  
Ramadan Fasting ◽  
Ulcer Disease ◽  
Upper Gastrointestinal

THE ASSOCIATION OF HELICOBACTER PYLORI INFECTION AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN PEPTIC-ULCER DISEASE

2004 ◽  
Vol 99 ◽  
pp. S44
Author(s):  
Juan C. Zapata-Colindres ◽  
Sergio Zepeda-Gomez ◽  
Aldo Montano-Loza ◽  
Edgar Vazquez-Ballesteros ◽  
Francisco Valdovinos-Andraca
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Helicobacter Pylori Infection ◽  
Ulcer Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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