scholarly journals Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Kayo Kuyama ◽  
Sisilia Fusi Fifita ◽  
Masamichi Komiya ◽  
Yan Sun ◽  
Yoshiaki Akimoto ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Immunohistochemical Study ◽  
Fat Cells ◽  
Fatty Tissue ◽  
Review Of The Literature ◽  
Woven Bone ◽  
Osteoid Tissue ◽  
Spindle Cells ◽  
S 100 ◽  
Lipomatous Tumors

The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 & and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

scholarly journals Immunohistochemical study of a canine neurofibroma

2012 ◽  
Vol 83 (1) ◽  
Author(s):  
Hamidreza Fattahian ◽  
Pejman Mortazavi ◽  
Hamidreza Moosavian ◽  
Hamid Mohyeddin ◽  
Roozbeh Moridpour
Keyword(s):  
Case Report ◽  
Diagnostic Imaging ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Immunohistochemical Study ◽  
Collagen Fibres ◽  
Spindle Cells ◽  
Left Mandible ◽  
S 100 ◽  
Diagnostic Approaches

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.

Aneurysmal Bone Cyst of the Larynx Presenting With Hypoglottic Obstruction

2001 ◽  
Vol 125 (5) ◽  
pp. 673-676
Author(s):  
Duilio Della Libera ◽  
Gillian Redlich ◽  
Lucia Bittesini ◽  
Giovanni Falconieri
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Radical Surgery ◽  
Bone Cyst ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Review Of The Literature ◽  
Osteoid Tissue ◽  
Spindle Cells ◽  
Apparent Relationship

Abstract We report a new case of aneurysmal bone cyst of the larynx occurring in a 22-year-old man. The lesion manifested with progressive breathing discomfort and appeared as a polypoid pedunculated mass attached to the subglottic mucosa. Microscopically, it featured numerous mononuclear and multinucleated giant cells surrounding cavernous spaces filled with blood. Foci of proliferating spindle cells and mature osteoid tissue could be recognized. There was no apparent relationship with the cricoid perichondrium. Clinical follow-up was negative for local recurrence. Based on this report and a review of the literature, we conclude that aneurysmal bone cyst of the larynx is phenotypically comparable to its bone homologue; however, its microscopic recognition may be difficult, especially on small biopsy fragments. Since it can be confused with several lesions, including telangiectatic osteosarcoma, awareness of this rare appearance of aneurysmal bone cyst is important to avoid unnecessary radical surgery.

scholarly journals Lipomas of the Oral Cavity: Clinicopathological and Immunohistochemical Study of 24 Cases and Review of the Literature

2014 ◽  
Vol 67 (S1) ◽  
pp. 67-73 ◽  
Author(s):  
Tomofumi Naruse ◽  
Souichi Yanamoto ◽  
Shin-ichi Yamada ◽  
Satoshi Rokutanda ◽  
Akiko Kawakita ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Immunohistochemical Study ◽  
Review Of The Literature

scholarly journals Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature

2011 ◽  
Vol 2011 ◽  
pp. 1-4
Author(s):  
Rosanna Zamparese ◽  
Francesco Corini ◽  
Antonio Braccischi ◽  
Antonella D'Angelo ◽  
Lucilla Diamanti ◽  
...  
Keyword(s):  
Final Diagnosis ◽  
Low Grade ◽  
Review Of The Literature ◽  
Uncertain Malignant Potential ◽  
Primary Sarcoma ◽  
Stromal Sarcoma ◽  
Spindle Cells ◽  
S 100 ◽  
Mitotic Figures ◽  
Transurethral Prostatic Resection

Primary sarcoma tumours of the prostate are rare and are classified, according to their histology, as stromal tumours of uncertain malignant potential (STUMP) and stromal prostatic sarcoma (PS; low and high grade). We describe a case of a 71-year-old man that developed progressive urinary obstruction symptoms and was subjected to a transurethral prostatic resection (TURP). Histologically, there is a diffuse proliferation of epithelioid and spindle cells that showed rare atypical mitotic figures. Immunohistochemically, the neoplastic cells express diffusely CD34 and focally progesterone whereas no immunoreactivity was seen for cytocheratin, desmin, S-100, Bcl-2, chromogranin, CD117, and actin smooth muscle. A final diagnosis of low-grade prostatic stromal sarcoma (LG-PS) was made. This is a really rare neoplasm; in the literature, in fact, to our knowledge, only 6 cases are described and all of these were alive and free of disease at followup. Our patient too is free of disease at 15 months from the diagnosis.

scholarly journals Inflammatory fibroid polyp: an immunohistochemical study

2004 ◽  
Vol 41 (2) ◽  
pp. 104-107 ◽  
Author(s):  
Gilda da Cunha Santos ◽  
Venâncio A.F. Alves ◽  
Alda Wakamatsu ◽  
Sérgio Zucoloto
Keyword(s):  
Smooth Muscle ◽  
Factor Viii ◽  
Immunohistochemical Study ◽  
Smooth Muscle Actin ◽  
Positive Staining ◽  
Muscle Actin ◽  
Inflammatory Fibroid Polyp ◽  
Spindle Cells ◽  
S 100 ◽  
Fibroid Polyp

BACKGROUND: Inflammatory fibroid polyp is a localized lesion, which arises in the submucosa of the gastrointestinal tract, most often in the stomach.Although it is generally believed to represent a reactive, nonneoplastic condition, its histogenesis remains controversial. AIM: To study inflammatory fibroid polyp by immunohistochemistry in an attempt to further clarify their histogenesis. MATERIAL AND METHODS: Nine cases were studied by immunohistochemistry using a panel of antibodies against smooth-muscle actin, vimentin, S-100 protein, factor VIII- R.Ag and macrophage (HAM-56). RESULTS: There was a strong diffuse positive staining pattern in the spindle cells with vimentin antibody. A patchy staining for smooth-muscle actin was observed in these cells. Immunophenotyping revealed a heterogeneous reaction with HAM-56. In edematous areas, HAM-56-positive cells show voluminous cytoplasm and reniform nuclei. In cell-rich areas, the HAM-56-positive cells had fusiform cytoplasm. Stains for S-100 and factor VIII RAg were negative in the proliferating elements. CONCLUSIONS: The present immunohistochemical study refutes the suggested neural or vascular nature of the lesion. The strong positivity for vimentin in all cases suggests a major component of spindle cells best recognizable as fibroblasts. These results would favor the existence of a span of morphological and immunohistochemical patterns possibly indicating evolutive phases of an inflammatory reaction.

scholarly journals Lipoma intraoral atípico: relato de caso

2020 ◽  
Vol 9 (3) ◽  
Author(s):  
Naíza Menezes Medeiros Abrahim ◽  
Gesom Avohai Dias Sombra ◽  
Jardel dos Santos Silva ◽  
André Luiz Carvalho Barreiros ◽  
Jeconias Câmara ◽  
...  
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Spindle Cell ◽  
Immunohistochemical Study ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Spindle Cell Lipoma ◽  
Maxillofacial Region ◽  
Rare Case Report ◽  
Head Neck

Os lipomas são tumores de tecido mole que raramente acometem a cavidade oral. A lesão apresenta variáveis clínicas e histopatológicas que não alteram seu prognóstico. Apesar de suas características comuns, a lesão pode estabelecer diagnóstico diferencial com outras lesões de tecido mole. O objetivo desse artigo é relatar a apresentação clínica não usual de um lipoma localizado em mucosa jugal com 3cm em sua maior extensão, em paciente do sexo masculino com 56 anos de idade. O plano de tratamento foi a biópsia excisional com excelente prognóstico.Descritores: Boca; Lipoma; Neoplasia Bucais.ReferênciasJuliasse LE, Nonaka CF, Pinto LP, Freitas Rde A, Miguel MC. Lipomas of the oral cavity: clinical and histopathologic study of 41 cases in a Brazilian population. Eur Arch Otorhinolaryngol. 2010;267(3):459-65.Naruse T, Yanamoto S, Yamada S, Rokutanda S, Kawakita A, Takahashi H et al. Lipomas of the oral cavity: clinicopathological and immunohistochemical study of 24 cases and review of the literature. Indian J Otolaryngol Head Neck Surg. 2015;67(Suppl 1):67-73.Manor E, Sion-Vardy N, Joshua BZ, Bodner L. Oral lipoma: analysis of 58 new cases and review of the literature. Ann Diagn Pathol. 2011;15(4):257-61.Avelar LR, Carvalho RWF, Falcão PGCB, Antunes AA, Andrade ESS et al. Lipomas da Região Oral e Maxilofacial: Estudo Retrospectivo de 16 Anos no Brasil. Rev Port Estomatol Cir Maxilofac 2008;49(4):207-11.Said-Al-Naief N, Zahurullah FR, Sciubba JJ. Oral spindle cell lipoma. Ann Diagn Pathol. 2001;5(4):207-15.Egido-Moreno S, Lozano-Porras AB, Mishra S, Allegue-Allegue M, Marí-Roig A, López-López J. Intraoral lipomas: Review of literature and report of two clinical cases. J Clin Exp Dent. 2016;8(5):e597-603. A RK, N PN, Y S, A VK, D KK. Intraoral lipoma: a rare case report and review of literature. J Clin Diagn Res. 2013;7(12):3090-91.Raj M, Ramadoss T, Anuradha G, Devi S. Intraoral lipoma: review of literature and case report. J Indian Acad Oral Med Radiol. 2012; 24(1):36-38Carvalho MF, Junqueira TP, Souza RR, Capistrano HM, Chaves MGAM.The importance of early diagnosis of large lipomas in the maxillofacial region. Rev Cubana Estomatol. 2011;48(1):77-83Noro Filho GA, Caputo BV, Santos CC, Souza RS, Giovani EM, Scabar LF et al. Diagnosis and treatment of intraoral lipoma: a case report. J Health Sci Inst. 2010;28(2):129-31.

Cerebral Malignant Nerve Sheath Tumor, Triton Tumor Variant: Case Report

2003 ◽  
Vol 6 (2) ◽  
pp. 168-172 ◽  
Author(s):  
Leticia Bornstein-Quevedo ◽  
Fabiola Peralta-Olvera ◽  
Alfonso Marhx-Bracho ◽  
Rodolfo Rodríguez-Jurado ◽  
Beatriz de Leon-Bojorge
Keyword(s):  
Clinical Evidence ◽  
Immunohistochemical Study ◽  
Nerve Sheath Tumor ◽  
Intraparenchymal Hemorrhage ◽  
Malignant Triton Tumor ◽  
Nerve Sheath ◽  
Spindle Cells ◽  
S 100 ◽  
History Of ◽  
The Right

A case of a cerebral malignant triton tumor in a 3-year-old boy with a 2-month history of frontal headache and no clinical evidence of neurofibromatosis is reported. The computed tomography (CT) scan showed a large, irregular tumor in the right parietooccipital lobe. A partial surgical resection was performed. Histologically, the tumor was highly cellular and consisted of spindle cells with hyperchromatic and pleomorphic nuclei. Focally, neoplastic cells with rhabdomyoblastic features were found. The immunohistochemical study showed that tumor cells were positive for S-100 protein and CD57, and the rhabdomyoblasts expressed desmin, Myo-D1, and myoglobin. During the postoperative period, a massive intraparenchymal hemorrhage was identified and surgical drainage was performed. The patient worsened and died 10 days after the first surgery. Postmortem study was not authorized. Six cases of cerebral malignant nerve sheath tumor have been described; however, primary intraparenchymal malignant triton tumor has not been previously described.

Gangliocytic Paraganglioma of the Duodenum: Case Report

1987 ◽  
Vol 73 (4) ◽  
pp. 425-429 ◽  
Author(s):  
Stefania Dante ◽  
Giuseppe Viale ◽  
Paolo Dalla Palma
Keyword(s):  
Case Report ◽  
Ganglion Cells ◽  
Neuron Specific Enolase ◽  
Gangliocytic Paraganglioma ◽  
Spindle Cells ◽  
S 100 ◽  
Neurofilament 200

A case of gangliocytic paraganglioma of the second portion of the duodenal loop is presented. The tumor was polypoid and, histologically, composed of mature ganglion cells, spindle cells and epithelial-like cells. Immunocytochemical examination demonstrated the presence of neurofilament 200 K and S-100 protein only in the first two types of cells; all the cells were positive for neuron-specific enolase. The reaction for cytokeratin was negative in all neoplastic components. According to morphologic and immunocytochemical findings, we suggest a hamartomatous nature of this entity.

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