scholarly journals Immunohistochemical study of a canine neurofibroma

2012 ◽  
Vol 83 (1) ◽  
Author(s):  
Hamidreza Fattahian ◽  
Pejman Mortazavi ◽  
Hamidreza Moosavian ◽  
Hamid Mohyeddin ◽  
Roozbeh Moridpour
Keyword(s):  
Case Report ◽  
Diagnostic Imaging ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Immunohistochemical Study ◽  
Collagen Fibres ◽  
Spindle Cells ◽  
Left Mandible ◽  
S 100 ◽  
Diagnostic Approaches

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.

scholarly journals Case report and immunohistochemical study of a malignant peripheral nerve sheath tumor in a dog

2017 ◽  
Vol 54 (4) ◽  
pp. 420
Author(s):  
Thaís De Almeida Moreira ◽  
Leandro Willian Borges ◽  
Talita Lopes Serra ◽  
Diego Petrocino Caetano ◽  
Marcelo Carrijo da Costa ◽  
...  
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Immunohistochemical Study ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
S 100

O tumor maligno da bainha do nervo periférico é raro e pouco descrito em cães. Classicamente, o termo “neurofibroma/sarcoma” é empregado quando o tumor é composto por células de Schwann e células perineurais. Neste relato são descritos os achados clínicos, histopatológicos e imuno-histoquímicos de um caso de tumor maligno da bainha do nervo periférico, provavelmente neurofibrossarcoma, localizado no subcutâneo do membro pélvico de um cão da raça Rottweiler. Os achados histopatológicos associados às observações imuno-histoquímicas contribuíram para o diagnóstico, sendo observada positividade para proteína S-100, vimentina e CD57, permitindo a diferenciação da neoplasia em questão de outros tumores malignos com características morfológicas similares.

Gangliocytic Paraganglioma of the Duodenum: Case Report

1987 ◽  
Vol 73 (4) ◽  
pp. 425-429 ◽  
Author(s):  
Stefania Dante ◽  
Giuseppe Viale ◽  
Paolo Dalla Palma
Keyword(s):  
Case Report ◽  
Ganglion Cells ◽  
Neuron Specific Enolase ◽  
Gangliocytic Paraganglioma ◽  
Spindle Cells ◽  
S 100 ◽  
Neurofilament 200

A case of gangliocytic paraganglioma of the second portion of the duodenal loop is presented. The tumor was polypoid and, histologically, composed of mature ganglion cells, spindle cells and epithelial-like cells. Immunocytochemical examination demonstrated the presence of neurofilament 200 K and S-100 protein only in the first two types of cells; all the cells were positive for neuron-specific enolase. The reaction for cytokeratin was negative in all neoplastic components. According to morphologic and immunocytochemical findings, we suggest a hamartomatous nature of this entity.

scholarly journals Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Kayo Kuyama ◽  
Sisilia Fusi Fifita ◽  
Masamichi Komiya ◽  
Yan Sun ◽  
Yoshiaki Akimoto ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Immunohistochemical Study ◽  
Fat Cells ◽  
Fatty Tissue ◽  
Review Of The Literature ◽  
Woven Bone ◽  
Osteoid Tissue ◽  
Spindle Cells ◽  
S 100 ◽  
Lipomatous Tumors

The purpose of this study was to determine the clinicopathological and immunohistochemical features of lipoma/fibrolipoma with rare occasions as osseous and/or chondroid differentiation in the oral cavity. Two cases of the tumors, who presented with a painless, relatively hard mass on the oral mucosa, were studied. These were consisted of a well-circumscribed mass of fatty tissue with chondroid and significant fibrous component intermixed with the lobules of fat cells with chondroid and woven bone component, respectively. Immunohistochemical study revealed that peripheral spindle cells around chondroid tissue stained diffusely for S-100 & and Sox-9, though peripheral spindle cells around osteoid tissue only stained for RUNX-2. According to review of the literature, lipoma/fibrolipoma with osseous and/or chondroid differentiation was 18 cases. Also fibrolipoma with osseous and chondroid differentiation is the first to be reported here. These results indicated that the cartilage/bone is produced by differentiation of undifferentiated mesenchymal cells of stroma.

Malignant Peripheral Nerve Sheath Tumor of Frontal Sinus: A Case Report, Literature Review, and Immunohistochemical Study

2017 ◽  
Vol 3 (1) ◽  
pp. 1-3
Author(s):  
Mojtaba Babaei Zarch ◽  
Mansour Moghimi ◽  
Mohammad Hossein Dadgarnia ◽  
Seyed Mojtaba Ghelmani ◽  
Mohammad Baghi Yazdi ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Peripheral Nerve ◽  
Frontal Sinus ◽  
Immunohistochemical Study ◽  
Nerve Sheath Tumor ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath

scholarly journals Desmoplastic melanoma associated with an intraepidermal lentiginous lesion: case report and literature review

2013 ◽  
Vol 88 (3) ◽  
pp. 408-412 ◽  
Author(s):  
Cesar de Souza Bastos Junior ◽  
Juan Manuel Pineiro-Maceira ◽  
Fernando Manuel Belles de Moraes
Keyword(s):  
Case Report ◽  
De Novo ◽  
White Male ◽  
Collagen Deposition ◽  
Lentigo Maligna ◽  
Primary Cutaneous Melanoma ◽  
Reticular Dermis ◽  
Desmoplastic Melanoma ◽  
Spindle Cells ◽  
S 100

Desmoplastic melanoma tends to present as firm, amelanotic papules. Microscopically, it reveals a proliferation of fusiform cells in the dermis and variable collagen deposition, as well as intraepidermal melanocytic proliferation of lentiginous type in most cases. Biopsy in a 61-year-old white male patient, who had received a diagnosis of lentigo maligna on his face 10 years before, revealed a proliferation of dermal pigmented spindle cells and collagen deposition, reaching the deep reticular dermis, with a lentiginous component. Immunohistochemistry with S-100, Melan-A and WT1 showed positivity, but it was weak with HMB45. Desmoplastic melanoma associated with lentigo maligna was diagnosed. Several authors discuss whether desmoplastic melanoma represents a progression from the lentiginous component or arises "de novo". Desmoplastic melanoma represents a minority of cases of primary cutaneous melanoma (less than 4%). Identification of lentigo maligna indicates that desmoplastic melanoma should be carefully investigated.

Case Report of Isolated Schwannoma—A Rare Eyelid Tumor

2014 ◽  
Vol 07 (02) ◽  
pp. 143 ◽  
Author(s):  
Sudhir Singh ◽  
Subodh Saraf ◽  
Divyesh Goswami ◽  
Sumit Singh ◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Benign Tumor ◽  
Excisional Biopsy ◽  
Histopathologic Examination ◽  
Eyelid Tumor ◽  
Uveal Tract ◽  
Neural Sheath

Schwannoma (neurilemmoma) is a benign tumor of the peripheral nerve arising from Schwann cells that form the neural sheath. Schwannoma of ophthalmic interest is rare. Although it has been reported in relation to the orbit, and less frequently with the uveal tract and conjunctiva, instances of eyelid Schwannoma are extremely uncommon. We report a case of a 18-year-old male who developed eyelid Schwannoma. The mass was surgically removed by excisional biopsy. The histopathologic examination showed Schwannoma.

scholarly journals Spindle Cell Lipoma: A Case Report And Review Of Literature

2013 ◽  
Vol 10 (2) ◽  
pp. 92-95 ◽  
Author(s):  
P Chandrashekar ◽  
M Jose ◽  
M Dadhich ◽  
L Chatra ◽  
V Holla
Keyword(s):  
Medical Journal ◽  
Case Report ◽  
Spindle Cell ◽  
Histopathological Examination ◽  
English Literature ◽  
Review Of Literature ◽  
Spindle Cell Lipoma ◽  
Collagen Fibres ◽  
Spindle Cells ◽  
Rare Lesion

Oral spindle cell lipoma is a rare lesion and until now only 26 cases have been reported in English literature. In this article we report a case of oral spindle cell lipoma presented to our institution in July 2011, as an asymptomatic solitary growth of the buccal mucosa in a 58 year old male patient. On histopathological examination the lesion exhibited an admixture of adipocytes and spindle cells with collagen fibres and numerous mast cells. Kathmandu University Medical Journal | Vol.10 | No. 2 | Issue 38 | Apr – June 2012 | Page 92-95 DOI: http://dx.doi.org/10.3126/kumj.v10i2.7353

scholarly journals Large solitary neurofibroma of the cheek mucosa: a case report

2021 ◽  
Vol 10 (2) ◽  
pp. e56810212905
Author(s):  
Andre Luis Costa Cantanhede ◽  
Carolinne da Gloria Araújo ◽  
Priscila Mayara Silva de Almeida ◽  
Hassan Lavalier de Oliveira Lima
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Schwann Cells ◽  
Histological Examination ◽  
Unusual Case ◽  
Surgical Excision ◽  
Benign Tumors ◽  
Intraoral Approach ◽  
S 100 ◽  
Neural Origin

Neurofibromas are uncommon benign tumors in the oral cavity, which are composed of Schwann cells, perineural-like cells, and fibroblasts. The diagnosis can be confirmed by histological examination and immunopositivity for the S-100 protein indicating its neural origin. Surgical excision is the treatment of choice, and the intraoral approach is the best route for a medium-sized lesion and the prognosis is excellent. This paper aims at to present a unusual case of large neurofibroma located at the cheek mucosa of a young man and review important aspects of this tumor in the oral cavity.

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