scholarly journals Management of Esophageal Carcinoma Associated with Cirrhosis: A Retrospective Case-Control Analysis

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Florence Trivin ◽  
Eveline Boucher ◽  
Elodie Vauléon ◽  
Isabelle Cumin ◽  
Elisabeth Le Prisé ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Esophageal Carcinoma ◽  
Case Control ◽  
Control Analysis ◽  
Retrospective Case ◽  
Compensated Cirrhosis ◽  
Dismal Prognosis ◽  
Chemotherapy Dose ◽  
Case Control Analysis ◽  
Control Study

Objectives. Esophageal carcinoma and cirrhosis have the overlapping etiologic factors.Methods. In a retrospective analysis conducted in 2 Breton institutions we wanted to asses the frequency of this association and the outcome of these patients in a case-control study where each case (cirrhosis and esophageal cancer) was paired with two controls (esophageal cancer).Results. In a 10-year period, we have treated 958 esophageal cancer patients; 26 (2.7%) had a cirrhosis. The same treatments were proposed to the 2 groups; cases received nonsignificantly different radiation and chemotherapy dose than controls. Severe toxicities and deaths were more frequent among the cases. At the end of the treatment 58% of the cases and 67% of the controls were in complete remission; median and 2-year survival were not different between the 2 groups. All 4 Child-Pugh B class patients experienced severe side effects and 2 died during the treatment.Conclusions. This association is surprisingly infrequent in our population! Child-Pugh B patients had a dismal prognosis and a bad tolerance to radiochemotherapy; Child-Pugh A patients have the same tolerance and the same prognosis as controls and the evidence of a well-compensated cirrhosis has not modified our medical options.

Evaluation of Hypertriglyceridemia as a Mediator Between Endocrine Diseases and Pancreatitis in Dogs

2019 ◽  
Vol 55 (2) ◽  
pp. 92-100 ◽  
Author(s):  
Hakhyun Kim ◽  
Ji-Houn Kang ◽  
Tae-Young Heo ◽  
Byeong-Teck Kang ◽  
Gonhyung Kim ◽  
...  
Keyword(s):  
Medical Records ◽  
Multiple Logistic Regression Analysis ◽  
Case Control ◽  
Control Analysis ◽  
Retrospective Case ◽  
Endocrine Diseases ◽  
Matched Case ◽  
Case Control Analysis ◽  
Control Study

ABSTRACT The role of hypertriglyceridemia (HTG) secondary to endocrine diseases in the occurrence of pancreatitis in dogs has not been fully investigated. The objective of the present study was to evaluate HTG as a mediator between endocrine diseases and pancreatitis in dogs. The study design was a retrospective case-control study. Medical records of dogs newly diagnosed with acutely presenting pancreatitis between 2012 and 2014 were reviewed for the presence or absence of hyperadrenocorticism (HAC), diabetes mellitus (DM), and hypothyroidism. A matched case-control analysis was performed, and the association between endocrine diseases and pancreatitis was evaluated using multiple logistic regression analysis. In dogs with pancreatitis, the odds of HAC (P < .001) and DM (P < .001) were 4.5 and 12.4 times that of dogs without pancreatitis, respectively. HTG significantly mediated the association between DM and pancreatitis but not between HAC and pancreatitis. Additional studies will be necessary to confirm these findings and to further elucidate the associations between endocrine diseases and pancreatitis.

Outbreak ofSerratia marcescensColonization and Infection Traced to a Healthcare Worker With Long-Term Carriage on the Hands

2006 ◽  
Vol 27 (11) ◽  
pp. 1153-1158 ◽  
Author(s):  
Jutte J. C. de Vries ◽  
Willy H. Baas ◽  
Kees van der Ploeg ◽  
Albêrt Heesink ◽  
John E. Degener ◽  
...  
Keyword(s):  
Medical Center ◽  
Case Control ◽  
Control Analysis ◽  
Epidemic Strain ◽  
Retrospective Case ◽  
Neurosurgical Intensive Care ◽  
Neurosurgical Intensive Care Unit ◽  
Case Control Analysis ◽  
Control Study

Objective.To reveal the source of a nosocomial outbreak of colonization and infection with a strain ofSerratia marcescenspositive for Guiana extended-spectrumβ-lactamase 1 (GES-1) that occurred among patients in a neurosurgical intensive care unit (ICU) in a Dutch university medical center from May 2002 through March 2003.Methods.Samples from the environment and from the hands of healthcare workers (HCWs) were cultured. A retrospective case-control study was carried out.Results.Fifteen neurosurgical ICU patients who had 1 or more cultures that yielded the epidemic strain ofS. marcescensfrom May 2002 through March 2003 were defined as case patients and matched with 30 control patients. Environmental cultures did not reveal a prominent source ofS. marcescens. Cultures of specimens from the hands of 100 HCWs revealed colonization of a single HCW with the epidemic strain. Although this HCW instantly went on leave, serial cultures detected prolonged carriage of the epidemic strain on the hands of the HCW for 3 months. The skin of the HCW's hands was psoriatic. The epidemic abruptly ended after the colonized HCW went on leave. Retrospective case-control analysis showed that the patients colonized or infected withS. marcescensreceived significantly more nursing care from the colonized HCW than did control patients (P<.05). From February 2004 through October 2004, a second cluster of 3 patients was detected with the epidemic strain ofS. marcescens. In October 2004, the formerly colonized HCW appeared to have carriage of the epidemic strain on the hands again.Conclusions.A single HCW with the epidemic strain ofS. marcescenson the hands was considered the source of this outbreak.

Abstract TP216: Subtle Cardiovascular Measures in Young-onset Cryptogenic Ischemic Stroke: A Prospective Case-control Study

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Nicolas Martinez-Majander ◽  
Daniel Gordin ◽  
Jani Pirinen ◽  
Juha Sinisalo ◽  
Mika Lehto ◽  
...  
Keyword(s):  
Heart Rate ◽  
Case Control Study ◽  
Augmentation Index ◽  
Supply And Demand ◽  
Case Control ◽  
Applanation Tonometry ◽  
Control Analysis ◽  
Independent Association ◽  
Case Control Analysis ◽  
Control Study

Background: Worldwide, ≈1.3 million annual ischemic strokes (IS) occur in young adults (<50 years of age), of which up to 50% remain cryptogenic after a complete diagnostic work-up. In a pilot case-control study, we studied the value of arterial stiffness and related subendocardial viability in the search of underlying pathophysiology in these patients. Methods: We prospectively enrolled 51 patients aged 18-49 with recent imaging-positive cryptogenic IS and 51 age- and sex-matched stroke-free controls (NCT01934725). Measurements were done with an applanation tonometry (SphygmoCor). Augmentation Index (AIx) served as a measure of stiffness in small arteries. Aortic and brachial pulse wave velocities (aPWV; bPWV) reflected stiffness in large and intermediate-sized arteries, respectively. Subendocardial viability ratio (SEVR) was derived from radial artery waveform measures, reflecting myocardial oxygen supply and demand. Related-samples statistics were applied for univariate case-control analyses and linear regression to explore the relationship between parameters with significant association in case-control analysis. Results: AIx, aPWV, bPWV, heart rate, and systolic or diastolic blood pressures did not differ statistically between patients and controls. Mean SEVR was significantly lower in patients compared with controls (148±35 vs. 161±29, P=0.003). In patients, higher heart rate was inversely associated with SEVR (P<0.001). Age, sex, migraine with and without aura, smoking, and systolic and diastolic blood pressure showed no independent association with SEVR. Conclusions: To our knowledge, this is the first report to show an association between SEVR and stroke. Yet unrecognized subtle cardiovascular pathology may play a role in early-onset cryptogenic IS.

scholarly journals A 10-YEAR RETROSPECTIVE CASE-CONTROL ANALYSIS OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW AT A MAJOR TERTIARY CARE DENTAL INSTITUTION

2019 ◽  
Vol 128 (1) ◽  
pp. e51
Author(s):  
Dr. Laurel Henderson ◽  
Mrs. Amna Imran ◽  
Ms. Pardis Barati Mahvar ◽  
Mr. Andrew Sanapanya ◽  
Dr. Parish P. Sedghizadeh
Keyword(s):  
Tertiary Care ◽  
Osteonecrosis Of The Jaw ◽  
Case Control ◽  
Control Analysis ◽  
Retrospective Case ◽  
Case Control Analysis

scholarly journals Statin Use Is Associated With Reduced Risk of Histologic Subtypes of Esophageal Cancer: A Nested Case-Control Analysis

2014 ◽  
Vol 146 (3) ◽  
pp. 661-668 ◽  
Author(s):  
Leo Alexandre ◽  
Allan B. Clark ◽  
Hina Y. Bhutta ◽  
Sean Holt ◽  
Michael P.N. Lewis ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Case Control ◽  
Control Analysis ◽  
Case Control Analysis ◽  
Nested Case Control ◽  
Histologic Subtypes ◽  
Reduced Risk ◽  
Statin Use

scholarly journals Association of bone mineral density with reoperation rate following instrumented lumbar spinal fusion: a retrospective cohort and case-control study

2019 ◽  
Author(s):  
Maximilian Thomas Löffler ◽  
Niklas Loreck ◽  
Nico Sollmann ◽  
Johannes Kaesmacher ◽  
Felix Zibold ◽  
...  
Keyword(s):  
Case Control Study ◽  
Cohort Analysis ◽  
Case Control ◽  
Control Analysis ◽  
Lumbar Spinal Fusion ◽  
Mineral Density ◽  
Lumbar Spinal ◽  
Case Control Analysis ◽  
Prevalence Of Osteoporosis ◽  
Control Study

Abstract Background Low bone mineral density (BMD) is believed to influence the outcome of instrumented spinal surgery and can lead to reoperation. Purpose of this retrospective cohort and case-control study was to investigate the association of BMD with the risk of reoperation following instrumented lumbar spinal fusion (LSF). Methods For the cohort analysis, 81 patients were included who received LSF with and without polymethyl methacrylate (PMMA)-augmentation. For the case-control analysis, 18 patients who had reoperation following LSF were matched to 26 patients who did not have reoperation (matching criteria: sex, age ± 5 years, fused levels, and augmentation). Opportunistic BMD screening was performed in perioperative CT scans using asynchronous calibration. Mean BMD was compared between patients with and without reoperation in augmented and non-augmented surgeries. Results In the cohort analysis, prevalence of osteoporosis (BMD < 80 mg/cm³) was 29% in non-augmented and 85% in augmented LSF. Seven of 48 patients with non-augmented (15%) and 4 of 33 patients with augmented LSF (12%) had reoperation. In non-augmented LSF, patients with reoperation had significantly lower BMD than patients without reoperation (p = 0.005). In the case-control analysis, patients with reoperation presented numerically lower BMD of 78.8 ± 33.1 mg/cm³ than patients without reoperation with BMD of 89.4 ± 39.7 mg/cm³ (p = 0.357).Conclusions Prevalence of osteoporosis in patients undergoing LSF is relatively high. Patients with reoperation following LSF showed slightly lower BMD compared to matched patients without reoperation, but the difference was not statistically significant. Opportunistic BMD screening in preoperative CT is feasible and can provide valuable information about osteoporotic bone status.

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