scholarly journals A 10-YEAR RETROSPECTIVE CASE-CONTROL ANALYSIS OF MEDICATION-RELATED OSTEONECROSIS OF THE JAW AT A MAJOR TERTIARY CARE DENTAL INSTITUTION

2019 ◽  
Vol 128 (1) ◽  
pp. e51
Author(s):  
Dr. Laurel Henderson ◽  
Mrs. Amna Imran ◽  
Ms. Pardis Barati Mahvar ◽  
Mr. Andrew Sanapanya ◽  
Dr. Parish P. Sedghizadeh
Keyword(s):  
Tertiary Care ◽  
Osteonecrosis Of The Jaw ◽  
Case Control ◽  
Control Analysis ◽  
Retrospective Case ◽  
Case Control Analysis

scholarly journals Management of Esophageal Carcinoma Associated with Cirrhosis: A Retrospective Case-Control Analysis

2009 ◽  
Vol 2009 ◽  
pp. 1-5 ◽  
Author(s):  
Florence Trivin ◽  
Eveline Boucher ◽  
Elodie Vauléon ◽  
Isabelle Cumin ◽  
Elisabeth Le Prisé ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Esophageal Carcinoma ◽  
Case Control ◽  
Control Analysis ◽  
Retrospective Case ◽  
Compensated Cirrhosis ◽  
Dismal Prognosis ◽  
Chemotherapy Dose ◽  
Case Control Analysis ◽  
Control Study

Objectives. Esophageal carcinoma and cirrhosis have the overlapping etiologic factors.Methods. In a retrospective analysis conducted in 2 Breton institutions we wanted to asses the frequency of this association and the outcome of these patients in a case-control study where each case (cirrhosis and esophageal cancer) was paired with two controls (esophageal cancer).Results. In a 10-year period, we have treated 958 esophageal cancer patients; 26 (2.7%) had a cirrhosis. The same treatments were proposed to the 2 groups; cases received nonsignificantly different radiation and chemotherapy dose than controls. Severe toxicities and deaths were more frequent among the cases. At the end of the treatment 58% of the cases and 67% of the controls were in complete remission; median and 2-year survival were not different between the 2 groups. All 4 Child-Pugh B class patients experienced severe side effects and 2 died during the treatment.Conclusions. This association is surprisingly infrequent in our population! Child-Pugh B patients had a dismal prognosis and a bad tolerance to radiochemotherapy; Child-Pugh A patients have the same tolerance and the same prognosis as controls and the evidence of a well-compensated cirrhosis has not modified our medical options.

scholarly journals COVID-19 with early neurological and cardiac thromboembolic phenomena—timeline of incidence and clinical features

2021 ◽  
Author(s):  
Uma Sundar ◽  
Sanah Merchant ◽  
Meera Shah ◽  
Amita Mukhopadhyay ◽  
Shaonak Kolte ◽  
...  
Keyword(s):  
Tertiary Care ◽  
Binary Logistic Regression ◽  
Case Control ◽  
Respiratory Support ◽  
Binary Logistic Regression Analysis ◽  
Case Group ◽  
Control Analysis ◽  
Chi Square ◽  
Coronary Syndrome ◽  
Case Control Analysis

Background: At our tertiary care public hospital, we saw COVID-19 presenting with thromboembolic phenomena, indicating a possible early thrombo-inflammatory pathology. Objectives: We documented patients with cardiac and neurological thromboembolic phenomena as a primary presentation of COVID-19, and compared a subset of COVID associated strokes against COVID-19 patients without thrombotic manifestations. Methods: We included all COVID-Stroke and COVID-ACS (COVID-19, with ischemic arterial stroke/Acute Coronary Syndrome presenting prior to/simultaneous with/within 72 hours of systemic/respiratory COVID manifestations) admitted from April to November 2020. In the nested case control analysis, we used unpaired T-test and chi-square test to study differences between COVID-Strokes (case group) and non-thrombotic COVID controls. Results and Conclusions: We noted 68 strokes and 122 ACS associated with COVID-19. ACS peaked in May-June, while stroke admissions peaked later in September-October, possibly because severe strokes may have expired at home during the lockdown. In the case-control analysis, cases (n=43; 12F:31M; mean age 51.5 years) had significantly higher D-Dimer values than controls (n=50; 9F:41M; mean age 51.6 years). Mortality was significantly higher in cases (51.2% vs. 26.0%; p = 0.018). We noted 7.5 times higher mortality in cases versus controls even among patients needing minimal oxygen support. Imaging in 37 patients showed both anterior and posterior circulation territories affected in seven, with almost half of Carotid territory strokes being large hemispherical strokes. Additionally, CT/MRI angiography in 28 strokes showed large vessel occlusions in 19 patients. Death in cases thus probably occurred before progression to intense respiratory support, due to severe central nervous system insult. Binary logistic regression analysis showed respiratory support intensity to be the sole independent predictor of mortality among cases. Respiratory distress could have been due to COVID-19 lung infection or aspiration pneumonia resulting from obtunded sensorium. In controls, mortality was predicted by increasing age, female sex, and respiratory support intensity.

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