scholarly journals Gastrointestinal Stromal Tumor in Pregnancy: A Case Report

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
S. Scherjon ◽  
W. F. Lam ◽  
H. Gelderblom ◽  
F. W. Jansen
Keyword(s):  
Clinical Course ◽  
First Trimester ◽  
Optimal Management ◽  
Mesenchymal Tumors ◽  
Term Outcome ◽  
Long Term Outcome ◽  
First Choice ◽  
First Trimester Of Pregnancy ◽  
In Pregnancy

Background. Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract and are diagnosed relatively seldom in pregnancy.Case. We describe a remarkable clinical course and long-term outcome, now nine years after first diagnosis, of a massive and metastatic, with a high malignancy grade GIST case, found in and treated from the first trimester of pregnancy onwards.Conclusion. GIST occurring during pregnancy is extremely rare. However, early diagnosis is important for optimal management. The recent better understanding of oncogenesis, the use of immunohistochemistry for differential diagnosis of GISTs, and the use of imatinib mesylate as the treatment of first choice are—as shown in this case—important for care of pregnant women with this type of malignancy.

scholarly journals Primary sclerosing cholangitis and pregnancy

2011 ◽  
Vol 1 (3) ◽  
pp. 55 ◽  
Author(s):  
Casper Q. Kammeijer ◽  
Robert A. De Man ◽  
Christianne J.M. De Groot
Keyword(s):  
Ursodeoxycholic Acid ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Rare Case ◽  
Progressive Disease ◽  
High Dose ◽  
Term Outcome ◽  
Long Term Outcome ◽  
In Pregnancy

Primary sclerosing cholangitis is a progressive disease, and coincidentally in pregnancy it is rare. It is characterized by progressive inflammation and destruction of bile ducts finally resulting in liver failure. A rare case of primary sclerosing cholangitis in pregnancy is presented. The course of the pregnancy was marked by threatened preterm delivery and exacerbation of cholestasis. She was successfully treated with ursodeoxycholic acid (UDCA). Although, primary sclerosing cholangitis has both maternal and fetal effects on pregnancy, the overall outcome is favorable. Only few cases have been reported using high dose ursodeoxycholic acid for primary sclerosing cholangitis in pregnancy, it often improves pruritus but has no protection against stillbirth. Data on the safety to the fetus or neonate and long-term outcome are scarce.

scholarly journals Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors

2006 ◽  
Vol 155 (6) ◽  
pp. 823-829 ◽  
Author(s):  
Emanuele Ferrante ◽  
Monica Ferraroni ◽  
Tristana Castrignanò ◽  
Laura Menicatti ◽  
Mascia Anagni ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Pituitary Tumors ◽  
Term Outcome ◽  
Long Term Outcome ◽  
North West ◽  
Presenting Symptoms ◽  
Post Surgery ◽  
First Choice

Objective: The long-term outcome of non-functioning pituitary adenoma (NFPA) patients is not clearly established, probably due to the low annual incidence and prolonged natural history of these rare tumors. The aim of this study was to evaluate clinical data at presentation and long-term post-surgery and radiotherapy outcome in a cohort of patients with NFPA. Design and methods: A computerized database was developed using Access 2000 software (Microsoft Corporation, 1999). Retrospective registration of 295 NFPA patients was performed in seven Endocrinological Centers of North West Italy. Data were analyzed by STATA software. Results: The main presenting symptoms were visual defects (67.8%) and headache (41.4%) and the most frequent pituitary deficit was hypogonadism (43.3%), since almost all tumors were macroadenomas (96.5%). Surgery was the first choice treatment (98% of patients) and total debulking was achieved in 35.5%. Radiotherapy was performed as adjuvant therapy after surgery in 41% of patients. At the follow-up, recurrence occurred in 19.2% of patients without post-surgical residual tumor after 7.5 ± 2.6 years, regrowth in 58.4% of patients with post-surgical remnant after 5.3 ± 4.0 years and residue enlargement in 18.4% of patients post-surgically treated with radiotherapy after 8.1 ± 7.3 years. Conclusions: Our database indicates that the goal of a definitive surgical cure has been achieved during the last decade in a low percentage of patients with NFPA. This tumor database may help to reduce the delay between symptom onset and diagnosis, to assess prognostic parameters for the follow-up of patients with different risk of recurrence and to define the efficacy and safety of different treatments and their association with mortality/morbidity.

Long-Term Outcome of Patients Undergoing Balloon Mitral Valvotomy in Pregnancy

2005 ◽  
Vol 95 (12) ◽  
pp. 1504-1506 ◽  
Author(s):  
Harikrishnan Sivadasanpillai ◽  
Anand Srinivasan ◽  
Sivasankaran Sivasubramoniam ◽  
Krishnamoorthy Kavassery Mahadevan ◽  
Ajith Kumar ◽  
...  
Keyword(s):  
Term Outcome ◽  
Long Term Outcome ◽  
Mitral Valvotomy ◽  
In Pregnancy

scholarly journals Long-Term Outcome of Thrombolytic Therapy for Massive Pulmonary Embolism in Pregnancy

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Sy Van Hoang ◽  
Anh Tuan Vo ◽  
Kha Minh Nguyen
Keyword(s):  
Pulmonary Embolism ◽  
Pregnant Woman ◽  
Massive Pulmonary Embolism ◽  
Fibrinolytic Therapy ◽  
Shortness Of Breath ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Fetal Complications ◽  
In Pregnancy

A 25-year-old pregnant woman presented at 12 weeks of gestation with syncope and shortness of breath caused by massive pulmonary embolism. Due to persistent shock, fibrinolytic therapy with rtPA was administered. After fibrinolysis, clinical and hemodynamic response was excellent. No bleeding and fetal complications were recorded.

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