scholarly journals Short-and Long-Term Clinical Outcomes of Infliximab in Fulminant Ulcerative Colitis

Ulcers ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
J. Florholmen ◽  
G. Øverland ◽  
T. Olsen ◽  
R. Rismo ◽  
G. Cui ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Clinical Outcomes ◽  
Observation Time ◽  
Control Group ◽  
Infliximab Treatment ◽  
Fulminant Colitis ◽  
Superior Effect ◽  
Short And Long Term ◽  
Fulminant Ulcerative Colitis

The aim was to characterize short- and long-term clinical outcomes of infliximab in fulminant ulcerative colitis. Patients with severe ulcerative colitis meeting the criteria of fulminant colitis after 3 days of glucocorticosteroid treatment were randomized to control or additional induction therapy of infliximab followed by an on demand/maintenance therapy of infliximab. Twenty six patients with fulminant colitis were equally randomized. At Day 7, ten patients in the control group and none in the infliximab group were in the need of colectomy (). Due to superior effect of infliximab, patients in the control group were of ethical reasons transformed to infliximab treatment instead of performing colectomy. The probability to avoid colectomy was 0.66 with a median observation time of 52 months and a maximal of 91 months. The addition of azathioprine reduced the risk of late colectomy. We conclude that infliximab is effective in preventing early and late colectomy in fulminant colitis.

scholarly journals P160 SERUM ALBUMIN WEEK 6/WEEK 0 RATIO AFTER ANTI-TNF BEST PREDICTS BOTH SHORT- AND LONG-TERM CLINICAL OUTCOMES IN ANTI-TNF-NAïVE ULCERATIVE COLITIS PATIENTS

2018 ◽  
Vol 24 (suppl_1) ◽  
pp. S59-S60
Author(s):  
Sun-Ho Lee ◽  
Kiju Chang ◽  
Eun Mi Song ◽  
Sung Wook Hwang ◽  
Sang Hyoung Park ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Serum Albumin ◽  
Clinical Outcomes ◽  
Short And Long Term

scholarly journals Similar Short- and Long-term Colectomy Rates with Ciclosporin and Infliximab Treatment in Hospitalised Ulcerative Colitis Patients

2016 ◽  
Vol 10 (7) ◽  
pp. 821-827 ◽  
Author(s):  
Nicolette W. Duijvis ◽  
Anne S. ten Hove ◽  
Cyriel I. J. Ponsioen ◽  
Gijs R. van den Brink ◽  
Christianne J. Buskens ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Infliximab Treatment ◽  
Short And Long Term

P160 SERUM ALBUMIN WEEK 6/WEEK 0 RATIO AFTER ANTI-TNF BEST PREDICTS BOTH SHORT- AND LONG-TERM CLINICAL OUTCOMES IN ANTI-TNF-NAïVE ULCERATIVE COLITIS PATIENTS

2018 ◽  
Vol 154 (1) ◽  
pp. S85-S86
Author(s):  
Sun-Ho Lee ◽  
Kiju Chang ◽  
Eun Mi Song ◽  
Sung Wook Hwang ◽  
Sang Hyoung Park ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Serum Albumin ◽  
Clinical Outcomes ◽  
Short And Long Term

Time-Dependent Changes in Excitability After One-Trial Conditioning of Hermissenda

1997 ◽  
Vol 78 (6) ◽  
pp. 3460-3464 ◽  
Author(s):  
Terry Crow ◽  
Vilma Siddiqi
Keyword(s):  
Time Dependent ◽  
Control Group ◽  
Type B ◽  
Control Groups ◽  
Phototactic Behavior ◽  
Parallel Processes ◽  
Short And Long Term ◽  
A Site ◽  
Different Levels

Crow, Terry and Vilma Siddiqi. Time-dependent changes in excitability after one-trial conditioning of Hermissenda. J. Neurophysiol. 78: 3460–3464, 1997. The visual system of Hermissenda has been studied extensively as a site of cellular plasticity produced by classical conditioning. A one-trial conditioning procedure consisting of light paired with the application of serotonin (5-HT) to the exposed, but otherwise intact, nervous system produces suppression of phototactic behavior tested 24 h after conditioning. Short- and long-term enhancement (STE and LTE) of excitability in identified type B photoreceptors is a cellular correlate of one-trial conditioning. LTE can be expressed in the absence of STE suggesting that STE and LTE may be parallel processes. To examine the development of enhancement, we studied its time-dependent alterations after one-trial conditioning. Intracellular recordings from identified type B photoreceptors of independent groups collected at different times after conditioning revealed that enhanced excitability follows a biphasic pattern in its development. The analysis of spikes elicited by 2 and 30 s extrinsic current pulses at different levels of depolarization showed that enhancement reached a peak 3 h after conditioning. From its peak, excitability decreased toward baseline control levels 5–6 h after conditioning followed by an increase to a stable plateau at 16 to 24 h postconditioning. Excitability changes measured in cells from unpaired control groups showed maximal changes 1 h posttreatment that rapidly decremented within 2 h. The conditioned stimulus (CS) elicited significantly more spikes 24 h postconditioning for the conditioned group as compared with the unpaired control group. The analysis of the time-dependent development of enhancement may reveal the processes underlying different stages of memory for this associative experience.

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