Extramedullary Plasmacytoma of the Tonsil

2021 ◽

Vol 1 (1) ◽

Author(s):

Mohamed Hamdy Helal ◽

Ahmed Mohamed Bader ◽

Mohamed A. Fouad ◽

Malak Yousef Mohamed shoukheba

Keyword(s):

Soft Tissues ◽

Plasma Cells ◽

Malignant Neoplasm ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Solitary Plasmacytoma ◽

Upper Respiratory Tract ◽

Head And Neck Region ◽

Plasma Cell Neoplasm ◽

Disseminated Disease

The plasma cell neoplasm is a rare malignant neoplasm of plasma cells that may present as Extramedullary Plasmacytoma (EMP) in soft tissues especially in the upper respiratory tract, in the bone as a Solitary Plasmacytoma of bone (SPB), or as a part of the multifocal disseminated disease as Multiple Myeloma (MM). The majority of 80% occurs in the head and neck region. In our case, a 23-year-old female patient presented with a non-tender swelling of the gingiva in the upper and lower jaws with the mobility of all teeth. The radiological examination showed severe destruction of bone around all teeth.

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Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations

Otorhinolaryngology Clinics - An International Journal ◽

10.5005/jp-journals-10003-1134 ◽

2013 ◽

Vol 5 (3) ◽

pp. 157-163

Author(s):

Kerem Öztürk ◽

Mustafa Şahin ◽

Raşit Midilli ◽

Gülce Gürsan ◽

Nazan Özsan ◽

...

Keyword(s):

Head And Neck ◽

Soft Tissues ◽

Plasma Cells ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Mastoid Cavity ◽

Upper Respiratory Tract ◽

Head And Neck Region ◽

Systemic Dissemination ◽

Upper Respiratory

ABSTRACT Extramedullary plasmacytoma (EMP) is a rarely seen neoplasm of plasma cells which may be locally destructive by involving submucosal soft tissues of upper respiratory tract but without systemic dissemination. It comprises less than 1% of head and neck malignities. Clinical presentation depends on tumor's effect and its involvement site. Diagnosis is made with histopathologic examination of tissue biopsy. Responses to its treatment with local radiotherapy and surgery are similar. In this article; it is intended to update our knowledge regarding EMP and remind this rarely encountered disease by presenting various cases detected in nasopharynx, tonsil, buccal mucosa, larynx, mastoid cavity and sphenoid sinus, with literature line. How to cite this article Öztürk K, Şahin M, Midilli R, Gürsan G, Özsan N, Savaş R. Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations. Int J Otorhinolaryngol Clin 2013;5(3):157-163.

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Extramedullary plasmacytoma of the nasal cavity: A case report

Romanian Journal of Rhinology ◽

10.2478/rjr-2018-0026 ◽

2018 ◽

Vol 8 (32) ◽

pp. 233-234

Author(s):

Paskaramoorthy Sasitharan ◽

Nor Idayu Mohd Yusof ◽

Kugan Varatha Raju

Keyword(s):

Nasal Cavity ◽

Plasma Cells ◽

Clinical Laboratory ◽

Neck Region ◽

Young Female ◽

Extramedullary Plasmacytoma ◽

Head And Neck Region ◽

Systemic Involvement ◽

History Of ◽

Histopathologic Findings

Abstract Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells. It is most often located in the head and neck region. Extramedullary Plasmacytomas are more predominant in males who are in the 5th – 6th decade. In this report, this patient, who is a young female, presented to our clinic with history of intermittent nasal obstruction for the past year. She was diagnosed with extramedullary plasmacytoma and was subjected to radiotherapy. The clinical and histopathologic findings of plasmacytoma are discussed. In order to exclude systemic involvement, a systematic approach using clinical, laboratory and radiologic investigations was performed. Extramedullary plasmacytoma of the nasal cavity is rare and should be considered in the differential diagnosis of nasal cavity masses, especially in the young age group.

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Combined modality therapy for naso-oropharyngeal solitary extramedullary plasmacytoma: case report

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20174342 ◽

2017 ◽

Vol 3 (4) ◽

pp. 1105

Author(s):

Andrea Masarykova ◽

Marin Dzongov ◽

Alexandra Hanicova ◽

Ingrid Zavacka ◽

Danijela Scepanovic

Keyword(s):

Case Report ◽

Head And Neck ◽

Plasma Cell ◽

Fdg Pet ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Head And Neck Region ◽

Pet Ct ◽

Fdg Pet Ct ◽

Solitary Extramedullary Plasmacytoma

<p>Most patients with plasma cell neoplasia have generalized disease at diagnosis. However, some patients have a solitary extramedullary plasmacytomas (SEPs). SEPs are rare, typically solitary tumors comprising approximately 3–5% all plasma cell neoplasms. Almost 90% arise in the head and neck region, especially in the nasal cavity, sinuses, oropharynx, salivary glands and larynx. Solitary extramedullary plasmacytoma (SEP) has a predilection for the male gender and occurs most frequently in patients 50 years and older. SEP often runs an indolent clinical course with a tendency for local recurrence, and progresses to plasma cell myeloma in about 15% of patients. In this paper, we have reported the case of SEP of the naso-oropharynx in 55 years old woman who was presented with a sense of the nasal obstruction. The resection was performed and a mature plasmacytoma was demonstrated histologically. However, ENT examination and positron emission tomography/computed tomography examination with 18-fluorodeoxyglucose (18-FDG PET/CT) have shown that the patient had residual naso-oropharyngeal disease after surgery. A negative bone marrow biopsy and 18-FDG PET/CT have confirmed that it was a solitary extramedullary plasmacytoma of the head and neck region. Following the surgery, intensity modulated radiotherapy (IMRT) was administered. No relapse or progression to the multiple myeloma was recorded during the 3.5 years of follow-up. This case report, which describes a rare tumor of the naso-oropharynx, is expected to improve the recognition and referral of this condition in medical practice. </p>

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Extramedullary Plasmacytoma of Head and Neck Region: Report of Six Cases with Different Localizations

Otorhinolaryngology Clinics - An International Journal ◽

10.5005/aijoc-6-3-10 ◽

2014 ◽

Vol 6 (3) ◽

pp. 10-16 ◽

Cited By ~ 1

Author(s):

Kerem Öztürk ◽

Mustafa Şahin ◽

Raşit Midilli ◽

Gülce Gürsan ◽

Nazan Özsan ◽

...

Keyword(s):

Head And Neck ◽

Soft Tissues ◽

Plasma Cells ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Mastoid Cavity ◽

Upper Respiratory Tract ◽

Head And Neck Region ◽

Systemic Dissemination ◽

Upper Respiratory

ABSTRACT Extramedullary plasmacytoma (EMP) is a rarely seen neoplasm of plasma cells which may be locally destructive by involving submucosal soft tissues of upper respiratory tract but without systemic dissemination. It comprises less than 1% of head and neck malignities. Clinical presentation depends on tumor's effect and its involvement site. Diagnosis is made with histopathologic examination of tissue biopsy. Responses to its treatment with local radiotherapy and surgery are similar. In this article; it is intended to update our knowledge regarding EMP and remind this rarely encountered disease by presenting various cases detected in nasopharynx, tonsil, buccal mucosa, larynx, mastoid cavity and sphenoid sinus, with literature line.

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Extramedullary plasmacytoma of the nasal inferior turbinate: a case report

Journal of International Medical Research ◽

10.1177/03000605211062503 ◽

2021 ◽

Vol 49 (12) ◽

pp. 030006052110625

Author(s):

Yan Liu ◽

Xiaopei Yuan ◽

Xiaohong Peng ◽

Zhiming Xing ◽

Lisheng Yu

Keyword(s):

Multiple Myeloma ◽

Case Report ◽

Clinical Practice ◽

Plasma Cells ◽

Neck Region ◽

Inferior Turbinate ◽

Extramedullary Plasmacytoma ◽

Head And Neck Region ◽

Short Cycle

An extramedullary plasmacytoma (EMP) is a rare neoplasm characterized by monoclonal proliferation of plasma cells without features of multiple myeloma. Most EMPs occur in the head and neck region, especially in the aerodigestive tract. We herein report a case of an EMP arising from the nasal inferior turbinate. The mass was surgically removed, and a short cycle of radiotherapy was performed after the surgery. There was no recurrence of the tumor after 1 year of follow-up. These result may be useful for physicians who encounter similar situations in clinical practice.

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Extramedullary Plasmacytoma of Nasal Cavity

Clinical Rhinology An International Journal ◽

10.5005/jp-journals-10013-1265 ◽

2016 ◽

Vol 9 (1) ◽

pp. 50-52

Author(s):

Ravi Meher ◽

Swati Tandon

Keyword(s):

Nasal Cavity ◽

Head And Neck ◽

Soft Tissues ◽

Plasma Cells ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Upper Aerodigestive Tract ◽

Head And Neck Region ◽

Plasma Cell Neoplasms ◽

Extramedullary Plasmacytomas

ABSTRACT Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells in soft tissues. Extramedullary plasmacytomas constitute 3 to 5% of all plasma cell neoplasms. Most lesions occur in the head and neck, primarily in the upper aerodigestive tract, with 75% occurring in nose and paranasal sinuses. To the best of our knowledge, only few cases of sinonasal extramedullary plasmacytomas have been reported in the literature. It is important for otolaryngologists to acquire knowledge of this disease as 80 to 90% occur in the head and neck region. We report a rare case of extramedullary plasmacytoma of the nasal cavity in a 60-year-old male managed by surgery and radiotherapy. How to cite this article Tandon S, Meher R, Chauhan A. Extramedullary Plasmacytoma of Nasal Cavity. Clin Rhinol An Int J 2016;9(1):50-52.

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Extramedullary Plasmacytoma of the Larynx Treated by a Surgical Endoscopic Approach and Radiotherapy

Case Reports in Otolaryngology ◽

10.1155/2015/951583 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4

Author(s):

Massimiliano Pino ◽

Filippo Farri ◽

Pietro Garofalo ◽

Fausto Taranto ◽

Andrea Toso ◽

...

Keyword(s):

Plasma Cell ◽

Soft Tissues ◽

Neck Region ◽

Extramedullary Plasmacytoma ◽

Head And Neck Region ◽

History Of ◽

Uncommon Case ◽

Disseminated Disease ◽

Transoral Resection ◽

Suspension Laryngoscopy

Extramedullary plasmacytoma (EMP) is a rare variant of plasma cell myeloma that affects soft tissues. The head and neck region are the most affected sites, although others have also been described. Herein we report an uncommon case of EMP of the larynx in a 65-year-old male who presented with a history of progressive dysphonia and hoarseness. Laryngeal fiberscopy evidenced a reddish pedicled voluminous mass in the left false cords and ventricle. Microscopic suspension laryngoscopy was performed under general anaesthesia and a 4 W Acublade CO2 Laser was used for transoral resection of the lesion. This was followed by adjuvant radiotherapy, with the widely recommended doses on the supraglottic region, to achieve better local control. Diagnosis of EMP is based on immunohistochemistry and the exclusion of systemic plasma cell proliferative disorders. Diagnosis of solitary EMP can be made only if studies for disseminated disease and X-ray and/or magnetic resonance imaging of the spine, pelvis, femurs, and humerus and bone marrow biopsy are negative. As there are no internationally established guidelines, treatment of EMP is mainly based on consensus of expert opinion.

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