scholarly journals Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
K. C. Masoumi ◽  
Gina Shaw-Hallgren ◽  
Ramin Massoumi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Tumor Suppressor ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Hedgehog Signaling ◽  
Cancer Type ◽  
Skin Cancers

Ubiquitin and ubiquitin-related proteins posttranslationally modify substrates, and thereby alter the functions of their targets. The ubiquitination process is involved in various physiological responses, and dysregulation of components of the ubiquitin system has been linked to many diseases including skin cancer. The ubiquitin pathways activated among skin cancers are highly diverse and may reflect the various characteristics of the cancer type. Basal cell carcinoma and squamous cell carcinoma, the most common types of human skin cancer, are instances where the involvement of the deubiquitination enzyme CYLD has been recently highlighted. In basal cell carcinoma, the tumor suppressor protein CYLD is repressed at the transcriptional levels through hedgehog signaling pathway. Downregulation of CYLD in basal cell carcinoma was also shown to interfere with TrkC expression and signaling, thereby promoting cancer progression. By contrast, the level of CYLD is unchanged in squamous cell carcinoma, instead, catalytic inactivation of CYLD in the skin has been linked to the development of squamous cell carcinoma. This paper will focus on the current knowledge that links CYLD to nonmelanoma skin cancers and will explore recent insights regarding CYLD regulation of NF-κB and hedgehog signaling during the development and progression of these types of human tumors.

scholarly journals Histopathological pattern of skin cancer at tertiary referral skin health centre

2019 ◽  
Vol 9 (2) ◽  
pp. 1555-1559
Author(s):  
Ram Chandra Adhikari ◽  
Mahesh Shah ◽  
Anil Kumar Jha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Verrucous Carcinoma ◽  
Health Centre ◽  
Female Ratio ◽  
Skin Cancers

Background: The skin is a heterogeneous organ, capable of producing various types of skin tumors. The incidence of skin cancers, including melanoma and non-melanoma has been reported to have risen in many parts of the world. In Asian and African countries, individuals with pigmented races have a much lower incidence of skin cancers despite sunny hot weather. This study is aimed to analyze age, sex and site wise of distribution of skin cancers. Materials and Methods: The study included a total of 60 patients with histopathologically proven skin cancers from January 2015 to December 2018 in the department of pathology, DI skin health and referral centre, Kathmandu, Nepal. Results: A total of 60 cases of histopathologically proven skin cancer constituted 3.69% of total skin biopsies. Patient age ranged from 15 to 88 years with mean age being 61 years. The majority of the patients were in the age group of 61-70 yrs. The male to female ratio is 1:1.3. Basal cell carcinoma was the most common skin cancer constituting 43.4%, followed by squamous cell carcinoma (28.3%). The most common site of skin cancer is head & neck (73.3%), followed by lower extremities (8.3%). Other skin cancers were Bowen’s disease, melanoma, verrucous carcinoma, keratoacanthoma, trichilemmal carcinoma, extramammary Paget’s disease, Non-Hodgkin lymphoma and metastatic tumor. Conclusions: The most common type of skin cancer is basal cell carcinoma, followed by squamous cell carcinoma and head & neck being the commonest site.

Multifokale Neoplasien der Haut: Biologie, Ätiologie und zielgerichtete Therapien von nicht-melanozytärem Hautkrebs

2018 ◽  
Vol 6 (3) ◽  
pp. 135-146
Author(s):  
Ana R. Fernandes ◽  
Ana C. Santos ◽  
Elena Sanchez-Lopez ◽  
Andjekla B. Kovačević ◽  
Marta Espina ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Photodynamische Therapie ◽  
Zielgerichtete Therapien ◽  
Aktinische Keratose ◽  
Skin Cancers ◽  
Nonmelanoma Skin Cancers

Neoplastische Hautläsionen sind multifokal auftretende, diffuse Hautinfiltrationen, die besonders in der Differentialdiagnose ulzerativer, nodulärer oder verkrustender Hautläsionen von Bedeutung sind. Nicht-melanozytäre Hautkrebsformen (nonmelanoma skin cancers, NMSC) wie das Basalzellkarzinom (basal cell carcinoma, BCC), das Plattenepithelkarzinom (squamous cell carcinoma, SCC) und die aktinische Keratose (AK) sind die häufigsten malignen Tumoren beim Menschen. BCC wachsen langsam und bilden meist keine Metastasen, wohingegen SCC ein stärker infiltrierendes, destruierendes Wachstum zeigen und Metastasen bilden. AK sind Vorstufen des kutanen SCC. Bei der klassischen NMSC-Therapie kommt die photodynamische Therapie in Verbindung mit Chemotherapeutika zur Anwendung. Das zunehmende Verständnis der Pathomechanismen, die bei der Tumorentstehung, -progression und -differenzierung eine Rolle spielen, stützt die Anwendung zielgerichteter Chemotherapien zur Verringerung der Zytotoxizität klassischer Therapien. Die vorliegende Übersichtsarbeit beschreibt den aktuellen Wissensstand über NMSC, einschließlich der Risikofaktoren, Onkogene und Karzinogenese von Hautkrebs und erörtert die herkömmliche Behandlung im Vergleich zu neuartigen therapeutischen Optionen. Übersetzung aus Skin Pharmacol Physiol 2018;31:59-73 (DOI: 10.1159/000479529)

Geographic Pathology of Skin Cancer

1999 ◽  
Vol 3 (3) ◽  
pp. 120-122
Author(s):  
Robert Jackson
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Cancer ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Basal Cell ◽  
Sun Exposure

Background: The development of knowledge concerning the role of sun exposure in causing skin cancer has been a gradual one. Objective: This article reviews the article by Urbach who used manikin coated with an ultraviolet dosimeter to see exactly where on the head and neck the exposure was greatest. Conclusion: Urbach showed that the areas of greatest sun exposure on his manikins corresponded with the location of 95% of squamous cell carcinoma and 66% of basal cell carcinoma. He also clearly showed the importance of scattered sky and reflected radiation.

Relation Between Smoking and Skin Cancer

2001 ◽  
Vol 19 (1) ◽  
pp. 231-238 ◽  
Author(s):  
Sofie A.E. De Hertog ◽  
Christianne A.H. Wensveen ◽  
Maarten T. Bastiaens ◽  
Christine J. Kielich ◽  
Marjo J.P. Berkhout ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Risk Factor ◽  
Relative Risk ◽  
Skin Cancer ◽  
Malignant Melanoma ◽  
Basal Cell Carcinoma ◽  
Confidence Interval ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell

PURPOSE: Tobacco smoking is a risk factor for several cancers. The risk of cutaneous malignancies related to smoking, however, is relatively unknown. We investigated the possible association between smoking and skin cancer. PATIENTS AND METHODS: A hospital-based case-control study was performed that included 161 patients with squamous cell carcinoma, 301 with nodular basal cell carcinoma, 153 with superficial multifocal basal cell carcinoma, 125 with malignant melanoma, and 386 controls. Information on smoking history was collected in personal interviews. Relative risks were estimated using exposure odds ratios from cross-tabulation and logistic regression. RESULTS: An association between smoking and squamous cell carcinoma of the skin was found (relative risk, 2.3; 95% confidence interval, 1.5 to 3.6; P = .0001), with a higher risk for current smokers (relative risk, 3.3; 95% confidence interval, 1.9 to 5.5) than for former smokers (relative risk, 1.9; 95% confidence interval, 1.2 to 3.0). After adjustment for age, sex, and sun exposure, the relative risk of squamous cell carcinoma was 2.0 (95% confidence interval, 1.2 to 3.2; P = .008). There was a dose-response relationship with number of cigarettes and pipes smoked. No significant association was found between smoking and nodular basal cell carcinoma, superficial multifocal basal cell carcinoma, or malignant melanoma. CONCLUSION: Tobacco smoking is an independent risk factor for cutaneous squamous cell carcinoma.

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