scholarly journals Recent Applications of Liposomes in Ophthalmic Drug Delivery

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Gyan P. Mishra ◽  
Mahuya Bagui ◽  
Viral Tamboli ◽  
Ashim K. Mitra
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Half Life ◽  
Topical Delivery ◽  
Posterior Segment ◽  
Hydrophilic Polymers ◽  
Ophthalmic Drug Delivery ◽  
Liposomal Formulations ◽  
Ophthalmic Drug ◽  
Targeted Drug

Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature. Current approaches for topical delivery of liposomes are focused on improving the corneal adhesion and permeation by incorporating various bioadhesive and penetration enhancing polymers. In the case of posterior segment disorders improvement in intravitreal half life and targeted drug delivery to the retina is achieved by liposomes. In this paper we have attempted to summarize the applications of liposomes in the field of ophthalmic drug delivery by citing numerous investigators over the last decade.

scholarly journals The Hypotonic Environmental Changes Affect Liposomal Formulations for Nose-to-Brain Targeted Drug Delivery

2019 ◽  
Vol 108 (8) ◽  
pp. 2570-2579 ◽  
Author(s):  
Iren Yeeling Wu ◽  
Trygg Einar Nikolaisen ◽  
Nataša Škalko-Basnet ◽  
Massimiliano Pio di Cagno
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Environmental Changes ◽  
Liposomal Formulations ◽  
Targeted Drug

scholarly journals Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1685
Author(s):  
Ayah Mohammad Burhan ◽  
Butsabarat Klahan ◽  
Wayne Cummins ◽  
Vanessa Andrés-Guerrero ◽  
Mark E. Byrne ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Special Focus ◽  
Topical Drug Delivery ◽  
Ophthalmic Drug Delivery ◽  
Mucoadhesive Polymers ◽  
Eye Tissues ◽  
Successful Design ◽  
Ophthalmic Drug

Posterior segment eye diseases (PSEDs) including age macular degeneration (AMD) and diabetic retinopathy (DR) are amongst the major causes of irreversible blindness worldwide. Due to the numerous barriers encountered, highly invasive intravitreal (IVT) injections represent the primary route to deliver drugs to the posterior eye tissues. Thus, the potential of a more patient friendly topical route has been widely investigated. Mucoadhesive formulations can decrease precorneal clearance while prolonging precorneal residence. Thus, they are expected to enhance the chances of adherence to corneal and conjunctival surfaces and as such, enable increased delivery to the posterior eye segment. Among the mucoadhesive polymers available, chitosan is the most widely explored due to its outstanding mucoadhesive characteristics. In this review, the major PSEDs, their treatments, barriers to topical delivery, and routes of topical drug absorption to the posterior eye are presented. To enable the successful design of mucoadhesive ophthalmic drug delivery systems (DDSs), an overview of mucoadhesion, its theory, characterization, and considerations for ocular mucoadhesion is given. Furthermore, chitosan-based DDs that have been explored to promote topical drug delivery to the posterior eye segment are reviewed. Finally, challenges of successful preclinical to clinical translation of these DDSs for posterior eye drug delivery are discussed.

scholarly journals Roles of Polyethylene Glycol on the Surface of Nanoparticles for Targeted Drug Delivery

Nanoscale ◽  
2021 ◽  
Author(s):  
Liwang Shi ◽  
Jinqiu Zhang ◽  
Man Zhao ◽  
Shukun Tang ◽  
Xu Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Polymeric Material ◽  
Targeted Drug Delivery ◽  
Rapid Development ◽  
Hydrophilic Polymers ◽  
Targeted Drug ◽  
Drug Nanocarriers

The rapid development of drug nanocarriers has benefited from surface hydrophilic polymers of particles, which has improved the drug's pharmacokinetics. Polyethylene glycol (PEG) is a kind of polymeric material with...

Targeted drug delivery vehicles mediated by nanocarriers and aptamers for posterior eye disease therapeutics: barriers, recent advances and potential opportunities

2021 ◽  
Author(s):  
Tingting Zhang ◽  
Xin Jin ◽  
Nan Zhang ◽  
Xinyi Jiao ◽  
Yuanyuan Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Posterior Segment ◽  
Drug Delivery Vehicles ◽  
Effective Strategies ◽  
Combined Application ◽  
Targeted Drug ◽  
Ophthalmic Therapy

Abstract Nanomedicine and aptamer have excellent potential in giving play to passive and active targeting respectively, which are considered to be effective strategies in the retro-ocular drug delivery system. The presence of closely adjoined tissue structures in the eye makes it difficult to administer the drug in the posterior segment of the eye. The application of nanomedicine could represent a new avenue for the treatment, since it could improve penetration, achieve targeted release, and improve bioavailability. Additionally, a novel type of targeted molecule aptamer with identical objective was proposed. As an emerging molecule, aptamer shows the advantages of penetration, non-toxicity, and high biocompatibility, which make it suitable for ocular drug administration. The purpose of this paper is to summarize the recent studies on the effectiveness of nanoparticles as a drug delivery to the posterior segment of the eye. This paper also creatively looks forward to the possibility of the combined application of nanocarriers and aptamers as a new method of targeted drug delivery system in the field of post-ophthalmic therapy.

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