scholarly journals Roles of Polyethylene Glycol on the Surface of Nanoparticles for Targeted Drug Delivery

Nanoscale ◽  
2021 ◽  
Author(s):  
Liwang Shi ◽  
Jinqiu Zhang ◽  
Man Zhao ◽  
Shukun Tang ◽  
Xu Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Polymeric Material ◽  
Targeted Drug Delivery ◽  
Rapid Development ◽  
Hydrophilic Polymers ◽  
Targeted Drug ◽  
Drug Nanocarriers

The rapid development of drug nanocarriers has benefited from surface hydrophilic polymers of particles, which has improved the drug's pharmacokinetics. Polyethylene glycol (PEG) is a kind of polymeric material with...

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 271-287 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Cancer Therapies ◽  
Medication Delivery ◽  
Lipid Nanocarriers ◽  
Targeted Drug ◽  
Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

RGD-decorated redox-responsived-α-tocopherol polyethylene glycol succinate–poly(lactide) nanoparticles for targeted drug delivery

2016 ◽  
Vol 4 (13) ◽  
pp. 2338-2350 ◽  
Author(s):  
Yuanyuan Guo ◽  
Boning Niu ◽  
Qingle Song ◽  
Yongdan Zhao ◽  
Yuling Bao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Targeted Drug Delivery ◽  
Glycol Succinate ◽  
Targeted Drug

A novel kind of copolymer, TPGS-SS-PLA, was successfully synthesized and applied in targeted drug delivery.

scholarly journals Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1832 ◽  
Author(s):  
Ylenia Jabalera ◽  
Francesca Oltolina ◽  
Ana Peigneux ◽  
Alberto Sola-Leyva ◽  
Maria P. Carrasco-Jiménez ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Magnetic Hyperthermia ◽  
Simultaneous Application ◽  
Biomimetic Nanoparticles ◽  
Targeted Drug ◽  
Model Drug ◽  
Drug Nanocarriers

The design of novel nanomaterials that can be used as multifunctional platforms allowing the combination of therapies is gaining increased interest. Moreover, if this nanomaterial is intended for a targeted drug delivery, the use of several guidance methods to increase guidance efficiency is also crucial. Magnetic nanoparticles (MNPs) allow this combination of therapies and guidance strategies. In fact, MNPs can be used simultaneously as drug nanocarriers and magnetic hyperthermia agents and, moreover, they can be guided toward the target by an external magnetic field and by their functionalization with a specific probe. However, it is difficult to find a system based on MNPs that exhibits optimal conditions as a drug nanocarrier and as a magnetic hyperthermia agent. In this work, a novel nanoformulation is proposed to be used as a multifunctional platform that also allows dual complementary guidance. This nanoformulation is based on mixtures of inorganic magnetic nanoparticles (M) that have been shown to be optimal hyperthermia agents, and biomimetic magnetic nanoparticles (BM), that have been shown to be highly efficient drug nanocarriers. The presence of the magnetosome protein MamC at the surface of BM confers novel surface properties that allow for the efficient and stable functionalization of these nanoparticles without the need of further coating, with the release of the relevant molecule being pH-dependent, improved by magnetic hyperthermia. The BM are functionalized with Doxorubicin (DOXO) as a model drug and with an antibody that allows for dual guidance based on a magnetic field and on an antibody. The present study represents a proof of concept to optimize the nanoformulation composition in order to provide the best performance in terms of the magnetic hyperthermia agent and drug nanocarrier.

Bioadhesive micelles of d -α-tocopherol polyethylene glycol succinate 1000: Synergism of chitosan and transferrin in targeted drug delivery

2017 ◽  
Vol 152 ◽  
pp. 277-288 ◽  
Author(s):  
Poornima Agrawal ◽  
Sonali ◽  
Rahul Pratap Singh ◽  
Gunjan Sharma ◽  
Abhishesh K. Mehata ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Targeted Drug Delivery ◽  
Glycol Succinate ◽  
Targeted Drug

scholarly journals Recent Applications of Liposomes in Ophthalmic Drug Delivery

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Gyan P. Mishra ◽  
Mahuya Bagui ◽  
Viral Tamboli ◽  
Ashim K. Mitra
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Half Life ◽  
Topical Delivery ◽  
Posterior Segment ◽  
Hydrophilic Polymers ◽  
Ophthalmic Drug Delivery ◽  
Liposomal Formulations ◽  
Ophthalmic Drug ◽  
Targeted Drug

Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-conjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature. Current approaches for topical delivery of liposomes are focused on improving the corneal adhesion and permeation by incorporating various bioadhesive and penetration enhancing polymers. In the case of posterior segment disorders improvement in intravitreal half life and targeted drug delivery to the retina is achieved by liposomes. In this paper we have attempted to summarize the applications of liposomes in the field of ophthalmic drug delivery by citing numerous investigators over the last decade.

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