scholarly journals One-Year Effectiveness of a 3-Week Balneotherapy Program for the Treatment of Overweight or Obesity

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Thierry Hanh ◽  
Patrick Serog ◽  
Jérôme Fauconnier ◽  
Pierre Batailler ◽  
Florence Mercier ◽  
...  
Keyword(s):  
Motivational Interview ◽  
Protocol Analysis ◽  
Controlled Trial ◽  
Dietary Advice ◽  
Obese Patients ◽  
One Year ◽  
The One ◽  
Randomised Controlled ◽  
Overweight Or Obesity

Objective. To assess the one-year effectiveness on weight loss of a 3-week balneotherapy program (BT).Method. A Zelen double consent randomised controlled trial to compare one-year BMI loss between a 3-week BT program versus usual care (UC) for overweight or obese patients (BMI: 27–35 kg/m2), associated or not with a dietary motivational interview (DMI) during the follow-up, using a 2 × 2 factorial design. Main analysis was a per protocol analysis comparing patients attending BT to patients managed by UC, matched on sex, overweight or obese status, DMI randomisation and a propensity score to attend BT or to be managed by UC.Results. From the 257 patients who completed the follow-up, 70 patients of each group could be matched. Mean BMI loss was 1.91 kg/m2[95%CI: 1.46; 2.35] for the BT patients and 0.20 kg/m2[−0.24; 0.64] for the UC patients (P<0.001), corresponding to a significant BT benefit of 1.71 kg/m2[1.08; 2.33]. There was no significant effect of DMI and no interaction with BT or UC. No adverse reaction was observed for patients attending BT.Conclusion. A 3-week BT program provided a significant one-year benefit over the usual GP dietary advice for overweight and obese patients.

Randomised controlled trial of total compared with subtotal hysterectomy with one-year follow up results

2003 ◽  
Vol 110 (12) ◽  
pp. 1088-1098 ◽  
Author(s):  
Helga Gimbel ◽  
Vibeke Zobbe ◽  
Birthe Margrethe Andersen ◽  
Thomas Filtenborg ◽  
Christian Gluud ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Subtotal Hysterectomy ◽  
One Year ◽  
Randomised Controlled

scholarly journals One-year follow-up of a randomised controlled trial on added splinting to eccentric exercises in chronic midportion Achilles tendinopathy

2008 ◽  
Vol 44 (9) ◽  
pp. 673-677 ◽  
Author(s):  
S. de Jonge ◽  
R. J. de Vos ◽  
H. T. M. Van Schie ◽  
J. A. N. Verhaar ◽  
A. Weir ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Achilles Tendinopathy ◽  
One Year ◽  
Randomised Controlled

scholarly journals Increasing dietary fibre intake in healthy adults using personalised dietary advice compared with general advice: a single-blind randomised controlled trial

2020 ◽  
pp. 1-12
Author(s):  
Iris Rijnaarts ◽  
Nicole M de Roos ◽  
Taojun Wang ◽  
Erwin G Zoetendal ◽  
Jan Top ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Dietary Fibre ◽  
Controlled Trial ◽  
Healthy Adults ◽  
Dietary Advice ◽  
Fibre Intake ◽  
Dietary Fibre Intake ◽  
Randomised Controlled ◽  
Single Blind

Abstract Objective: A high-fibre diet is associated with a lower risk for diseases. However, few adults meet the dietary fibre recommendation. Therefore, the effects and acceptance of an algorithm-generated personalised dietary advice (PDA) compared with general advice (GA) on fibre intake were investigated. Design: A 6-week, single-blind randomised controlled trial with a 3-month follow-up. Setting: PDA was based on habitual intake and provided fibre-rich alternatives using a website; GA contained brochures. Dietary intake was assessed at baseline, week 1, week 6 and 3-month follow-up. Both groups evaluated their advice at week 6. All participants had access to PDA from week 7 until 3-month follow-up. Participants: Two groups of healthy adults: PDA (n 34) and GA (n 47). For 3-month follow-up analysis, participants were re-divided into visitors (n 52) and non-visitors (n 26) of the PDA. Results: At week 6, energy intake remained stable in both groups, but fibre intake per 1000 kcal increased non-significantly in both groups (PDA = Δ0·5 ± 2·8; GA = Δ0·8 ± 3·1, P = 0·128). Importantly, a significantly higher percentage of PDA participants adhered to the recommendation compared with week 1 (PDA = 21 % increase; GA = 4 % increase, P ≤ 0·001). PDA participants evaluated the advice significantly better compared with GA participants. At 3-month follow-up, fibre intake increased compared with baseline (visitors = Δ2·2 ± 2·6, P < 0·001; non-visitors = Δ1·5 ± 1·9, P = 0·001), but was insignificantly different between groups. Visitors had a decrease and non-visitors had an increase in energy intake (visitors =Δ − 132 ± 525; non-visitors = Δ109 ± 507, P = 0·055). Conclusions: The algorithm-generated PDA was well accepted and stimulated adherence to the recommendations more than GA, indicating to be a suitable and cost-efficient method for improving dietary fibre intake in healthy adults.

Protective efficacy of 6-week regimen for latent tuberculosis infection treatment in rural China: 5-year follow-up of a randomised controlled trial

2021 ◽  
pp. 2102359
Author(s):  
Henan Xin ◽  
Xuefang Cao ◽  
Haoran Zhang ◽  
Boxuan Feng ◽  
Ying Du ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Protocol Analysis ◽  
Latent Tuberculosis Infection ◽  
Protective Efficacy ◽  
Controlled Trial ◽  
Latent Tuberculosis ◽  
Protection Rate ◽  
Ifn Γ ◽  
Randomised Controlled

BackgroundEnlarging tuberculosis (TB) preventive treatment among at-risk populations is a critical component of the End TB Strategy. It is urgently needed to develop suitable latent tuberculosis infection (LTBI) testing and treatment tools according to local TB epidemic and available resources in worldwide.MethodsBased on an open-labeled randomised controlled trial conducted since 2015 among rural residents aged 50–70 years with LTBI, the protective efficacy of the 6-week twice-weekly regimen of rifapentine plus isoniazid was further evaluated in a 5-year follow-up survey.ResultsA total of 1298 treated participants and 1151 untreated controls were included in the 5-year protective efficacy analysis. In the per-protocol analysis, the incidence rate was 0.49/100 person-years (95% confidence interval (CI): 0.30–0.67) in the untreated control group and 0.19/100 person-years (95% CI: 0.07–0.32) in the treated group, the protection rate was 61.22%. Subgroup analysis showed that the protection rate was 76.82% in the per-protocol analysis among participants with baseline IFN-γ levels in the highest quartile (≥3.25 IU·mL−1). The multiple logistic regression analysis indicated that participants with baseline BMI <18.5 kg·m−2 and with pulmonary fibrotic lesions had increased hazard of developing active disease with an adjusted hazard ratio (aHR) of 3.64 (95% CI: 1.20–11.00) and 5.99 (95% CI: 2.20–16.27), respectively. In addition, individuals with higher baseline IFN-γ levels showed an increased risk of TB occurrence (aHR 2.27, 95% CI 1.13–4.58).ConclusionsOur findings suggested the 6-week twice-weekly regimen of rifapentine plus isoniazid for LTBI treatment might be an optional tool for TB control in Chinese population.

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