scholarly journals Macrolides in Chronic Inflammatory Skin Disorders

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Abdullateef A. Alzolibani ◽  
Khaled Zedan
Keyword(s):  
Macrolide Antibiotic ◽  
Inflammatory Diseases ◽  
Case Reports ◽  
Term Therapy ◽  
Diffuse Panbronchiolitis ◽  
Pityriasis Lichenoides ◽  
Potential Benefits ◽  
Disease Modifying Agents ◽  
Long Term Therapy

Long-term therapy with the macrolide antibiotic erythromycin was shown to alter the clinical course of diffuse panbronchiolitis in the late 1980s. Since that time, macrolides have been found to have a large number of anti-inflammatory properties in addition to being antimicrobials. These observations provided the rationale for many studies performed to assess the usefulness of macrolides in other inflammatory diseases including skin and hair disorders, such as rosacea, psoriasis, pityriasis rosea, alopecia areata, bullous pemphigoid, and pityriasis lichenoides. This paper summarizes a collection of clinical studies and case reports dealing with the potential benefits of macrolides antibiotics in the treatment of selected dermatoses which have primarily been classified as noninfectious and demonstrating their potential for being disease-modifying agents.

scholarly journals Effect of Erythromycin on Chronic Respiratory Infection Caused by Pseudomonas aeruginosa with Biofilm Formation in an Experimental Murine Model

2004 ◽  
Vol 48 (6) ◽  
pp. 2251-2259 ◽  
Author(s):  
Towako Nagata ◽  
Hiroshi Mukae ◽  
Junichi Kadota ◽  
Tomayoshi Hayashi ◽  
Takeshi Fujii ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Murine Model ◽  
Biofilm Formation ◽  
Term Therapy ◽  
Diffuse Panbronchiolitis ◽  
Chronic Respiratory Infection ◽  
Model Treatment ◽  
Long Term Therapy

ABSTRACT Diffuse panbronchiolitis (DPB) is a chronic lower respiratory tract infection commonly associated with persistent late-stage Pseudomonas aeruginosa infection. However, low-dose long-term therapy with certain macrolides is effective in most patients with DPB. The present study was designed to examine the effects of long-term erythromycin (ERY) therapy by using our established murine model of chronic respiratory P. aeruginosa infection. ERY or saline was administered from day 80 after intubation with a P. aeruginosa-precoated tube for the subsequent 10, 20, 40, and 80 days. Bacteriologic and histologic analyses of the murine lungs and electron microscopy of the intubated tube were performed. In the murine model, treatment with ERY for 80 days significantly reduced the number of viable P. aeruginosa organisms in the lungs (P < 0.05). The biofilm formed in situ by P. aeruginosa on the inner wall of the inoculation tube placed into the murine bronchus became significantly thinner after 80 days of ERY treatment. We conclude that the clinical efficacy of macrolides in DPB may be due at least in part to the reduction in P. aeruginosa biofilm formation.

ANALYSIS OF 30 CASE REPORTS OF ACUTE POISONING WITH METFORMIN DURING LONG-TERM THERAPY

2010 ◽  
Vol 65 (sup1) ◽  
pp. 18-23 ◽  
Author(s):  
A. Garat ◽  
E. Tresch ◽  
F. Glowacki ◽  
D. Allorge ◽  
N. Houdret ◽  
...  
Keyword(s):  
Case Reports ◽  
Acute Poisoning ◽  
Term Therapy ◽  
Long Term Therapy

Meperidine-Related Seizures Associated with Patient-Controlled Analgesia Pumps

1993 ◽  
Vol 27 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Kathleen O. Hagmeyer ◽  
Laurie S. Mauro ◽  
Vincent F. Mauro
Keyword(s):  
Case Reports ◽  
Review Literature ◽  
Term Therapy ◽  
Patient Controlled Analgesia ◽  
Data Synthesis ◽  
Manual Search ◽  
High Doses ◽  
Long Term Therapy ◽  
Search Index

OBJECTIVE: To report three cases of meperidine-related seizures when meperidine was administered via patient-controlled analgesia pump (PCAP) and to review literature related to meperidine-associated seizures. DATA SOURCES: Case reports and review articles identified by a computerized search (MEDLINE) and manual search ( Index Medicus). DATA SYNTHESIS: PCAPs are being used frequently to relieve the pain of sickle cell crisis as well as pain from many other etiologies. We report three cases of meperidine-related seizures associated with its administration via PCAP. Each of the patients received either relatively high doses, long-term therapy, or both. Meperidine has been associated with seizure activity when administered via traditional routes. Previously identified risk factors for the development of meperidine-related seizures include renal failure, high meperidine dosages, and coadministration of hepatic enzyme-inducing medications or phenothiazines. CONCLUSIONS: Meperidine administered via PCAP may be associated with seizures. Optimally, an alternative analgesic should be administered when this route is used.

Vancomycin-Induced Neutropenia during Treatment of Endocarditis in a Pediatric Patient

1994 ◽  
Vol 28 (6) ◽  
pp. 723-726 ◽  
Author(s):  
Y. Todd Shinohara ◽  
James Colbert
Keyword(s):  
Pediatric Patient ◽  
Case Reports ◽  
Term Therapy ◽  
Vancomycin Therapy ◽  
Drug Induced ◽  
Case Summary ◽  
Drug Concentrations ◽  
Long Term Therapy ◽  
Possible Cause

OBJECTIVE: To report a case of reversible vancomycin-associated neutropenia occurring during long-term therapy with vancomycin using weight and age-adjusted dosing. CASE SUMMARY: A 2-year-old boy was started on vancomycin therapy for presumed endocarditis resulting from his ventriculoseptal defect. After 18 days of treatment, neutropenia with an absolute neutrophil count (ANC) of 990 × 106 cells/L was noted. The neutropenia progressed over the next 3 days and reached a nadir concentration of 459 × 106 cells/L. Vancomycin therapy was discontinued after 17 days (antibiotic day 20). A rise in the ANC occurred within 2 days of discontinuation. An improved ANC of 1672 × 106 cells/L occurred within 5 days. Vancomycin serum concentrations remained within an acceptable range: a peak of 30 μg/mL and a trough of 9 μg/mL. DISCUSSION: Case reports in the literature of vancomycin-associated neutropenia in adults were briefly reviewed and compared. The onset and resolution and mechanism of vancomycin-induced neutropenia were studied. The potential relationship between vancomycin, weight-, and age-adjusted dosing and the occurrence of neutropenia in our pediatric patient was postulated. CONCLUSIONS: Vancomycin is identified as a possible cause of drug-induced neutropenia. More data are needed that clearly indicate vancomycin as the offending agent in children. The vancomycin-induced neutropenia is believed to be immunologically based and independent of drug concentrations.

Antithrombotic Therapy for DVT/PE

1997 ◽  
Vol 17 (03) ◽  
pp. 161-162
Author(s):  
Thomas Hyers
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Oral Anticoagulants ◽  
Cost Effective ◽  
Therapeutic Agents ◽  
Great Promise ◽  
Term Therapy ◽  
Low Molecular Weight ◽  
Long Term Therapy

SummaryProblems with unfractionated heparin as an antithrombotic have led to the development of new therapeutic agents. Of these, low molecular weight heparin shows great promise and has led to out-patient therapy of DVT/PE in selected patients. Oral anticoagulants remain the choice for long-term therapy. More cost-effective ways to give oral anticoagulants are needed.

Office-based post-marketing surveillance study on the influence of long term therapy with aripiprazole in patients with schizophrenia

2007 ◽  
Vol 40 (05) ◽  
Author(s):  
M Kungel ◽  
A Engelhardt ◽  
T Spevakné-Göröcs ◽  
M Ebrecht ◽  
C Werner ◽  
...  
Keyword(s):  
Surveillance Study ◽  
Term Therapy ◽  
Post Marketing Surveillance ◽  
Post Marketing ◽  
Long Term Therapy
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