scholarly journals Association of Active Human Herpesvirus-6, -7 and Parvovirus B19 Infection with Clinical Outcomes in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Svetlana Chapenko ◽  
Angelika Krumina ◽  
Inara Logina ◽  
Santa Rasa ◽  
Maksims Chistjakovs ◽  
...  
Keyword(s):  
Viral Infection ◽  
Proinflammatory Cytokines ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
High Rate ◽  
Simultaneous Increase ◽  
Concurrent Infection ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6 ◽  
Healthy Persons

Frequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection and its association with clinical course of ME/CFS was evaluated. 108 ME/CFS patients and 90 practically healthy persons were enrolled in the study. Viral genomic sequences were detected by PCR, virus-specific antibodies and cytokine levels—by ELISA, HHV-6 variants—by restriction analysis. Active viral infection including concurrent infection was found in 64.8% (70/108) of patients and in 13.3% (12/90) of practically healthy persons. Increase in peripheral blood leukocyte DNA HHV-6 load as well as in proinflammatory cytokines' levels was detected in patients during active viral infection. Definite relationship was observed between active betaherpesvirus infection and subfebrility, lymphadenopathy and malaise after exertion, and between active B19 infection and multijoint pain. Neuropsychological disturbances were detected in all patients. The manifestation of symptoms was of more frequent occurrence in patients with concurrent infection. The high rate of active HHV-6, HHV-7 and B19 infection/coinfection with the simultaneous increase in plasma proinflammatory cytokines' level as well as the association between active viral infection and distinctive types of clinical symptoms shows necessity of simultaneous study of these viral infections for identification of possible subsets of ME/CFS.

A meta-analysis on association between viral infections and Kawasaki disease in children

2021 ◽  
Vol 16 (1) ◽  
pp. 27-41
Author(s):  
Mohammad Farahmand ◽  
Abbas Ahmadi-Vasmehjani ◽  
Abdoulreza Esteghamati ◽  
Shirin Sayyahfar ◽  
Sara Minaeian ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Viral Infections ◽  
Parvovirus B19 ◽  
Meta Analysis ◽  
Human Herpesvirus ◽  
Human Parvovirus B19 ◽  
Human Herpesvirus 6 ◽  
Viral Pathogens ◽  
Inverse Variance ◽  
Herpesvirus 6

Aim: To investigate the association between different viral infections and the development of Kawasaki disease (KD) in children. Materials & methods: Electronic databases were searched for relevant studies published from inception to May 2020. The pooled odds ratios (ORs) of the association of different viral pathogens with KD were estimated using a random-effects model weighted by the inverse variance method. Results: The strongest associations were found between KD and human parvovirus B19 viremia (OR = 41.05; 95% CI: 5.13–328.28; I-square = 0%), EBV IgM seropositivity (OR = 7.18; 95% CI: 3.65–14.12, I-square = 0%) and human herpesvirus-6 IgG seropositivity (OR = 5.83; 95% CI: 1.06–32.01). Conclusion: Human parvovirus B19, EBV and human herpesvirus-6 are highly suspected to be key contributors to the development of KD.

High Rate Of Reactivation Of Human Herpesvirus 6 In Children With Dengue Hemorrhagic Fever

1994 ◽  
Vol 170 (3) ◽  
pp. 746-747 ◽  
Author(s):  
K. Balachandra ◽  
K. Chimabutra ◽  
P. Supromajakr ◽  
C. Wasi ◽  
T. Yamamoto ◽  
...  
Keyword(s):  
Dengue Hemorrhagic Fever ◽  
Human Herpesvirus ◽  
Hemorrhagic Fever ◽  
High Rate ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

scholarly journals Detection of parvovirus B19 and human herpesvirus 6 in pediatric dilated cardiomyopathy: Impact after heart transplantation

2020 ◽  
Vol 13 (4) ◽  
pp. 301
Author(s):  
BibhutiB Das ◽  
BhupeshK Prusty ◽  
Jianli Niu ◽  
Meei-Li Huang ◽  
Haiying Zhu ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Dilated Cardiomyopathy ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

scholarly journals Primary human herpesvirus-6 and -7 infections, often coinciding, misdiagnosed as measles in children from a tropical region of Brazil

2003 ◽  
Vol 131 (2) ◽  
pp. 873-879 ◽  
Author(s):  
S. A. OLIVEIRA ◽  
D. J. TURNER ◽  
W. KNOWLES ◽  
J. P. NASCIMENTO ◽  
D. W. G. BROWN ◽  
...  
Keyword(s):  
Indirect Immunofluorescence ◽  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
Tropical Region ◽  
Human Herpesvirus 6 ◽  
Antibody Avidity ◽  
Tropical Conditions ◽  
Herpesvirus 6 ◽  
Immunofluorescence Antibody ◽  
Brazilian Children

We investigated primary human herpesvirus-6 and -7 (HHV-6, HHV-7) infections as a cause of rashes incorrectly diagnosed as measles in Brazilian children. Sera from 124 patients, aged 4 months to 17 years, from the states of Rio de Janeiro and Espírito Santo, in whom measles, rubella and parvovirus B19 infections had been excluded, were studied using indirect immunofluorescence antibody avidity tests; 38 (31%) had evidence of primary HHV-6 and/or HHV-7 infections. Twenty four children had primary HHV-6 infection, either recent or coincident with the rash, and similarly 31 had primary HHV-7 infection. Remarkably, almost half (17) of primary infections were dual HHV-6 and HHV-7 infections with the majority, 12 (71%), in children less than 1 year old. HHV-7 infection occurred earlier than previously reported, perhaps due to socioeconomic and tropical conditions in this region of Brazil, and thus coincided with the HHV-6 infections. This study also highlights the difficulties of diagnosing a rash illness on clinical grounds alone.

scholarly journals Molecular Detection of Epstein - Barr virus and Human Herpesvirus-6 in a Sample of Iraqi Patients with Acute Leukemia

2020 ◽  
Vol 11 (2) ◽  
pp. 2234-2240
Author(s):  
Arwa Mujahid Al-Shuwaikh ◽  
Dalya Basil Hanna ◽  
Asmaa B. Al-Obaidi ◽  
Ghaith Ali Jasim
Keyword(s):  
Acute Leukemia ◽  
Viral Infection ◽  
Epstein Barr Virus ◽  
Hematological Parameters ◽  
Human Herpesvirus ◽  
Control Group ◽  
Human Herpesvirus 6 ◽  
Barr Virus ◽  
Herpesvirus 6 ◽  
Epstein Barr

The pathogenic roles of human herpesvirus-6 (HHV-6) and Epstein-Barr virus (EBV) in acute leukemia have been of great interest. Patients with leukemia should be evaluated for viral infection, so they could be diagnosed for optimal therapy. In the current study, we aimed to determine the frequency of HHV-6 and EBV in a sample of Iraqi patients with acute leukemia in children and adults before chemotherapy. Fluorescent probe-based quantitative polymerase chain reaction (Q-PCR) method was used to quantify copies of HHV-6 and EBV DNA in 20 cases of acute lymphoblastic leukemia (AML), and 40 cases of hematological stable control subjects. Also, the effects of viral infection on hematological parameters were investigated. Results show that (47.5%) 19 out of 40 of patients at diagnosis recorded positive to one of the investigated viruses. Thirteen (32.5%) and 12 (30%) out of 40 patients with acute leukemia had positive EBV and HHV-6 viremia, respectively, while none of control group shows positive result with highly significant differences between patients and control groups (P<0.001). The mean EBV and HHV-6 viral load was (7737.615±9106.838 copies/ml) and (94393.58±214528.9 copies/ml), respectively. In this study, there was no significant association between viral infection and hematological parameters (P>0.05).In conclusion, infections or co-infections with EBV and HHV-6 could be a factor in the development of acute leukemia but further studies are required to establish whether there is a real association.

scholarly journals Fatal Myocarditis Associated with Acute Parvovirus B19 and Human Herpesvirus 6 Coinfection

2001 ◽  
Vol 39 (12) ◽  
pp. 4585-4587 ◽  
Author(s):  
J. Rohayem ◽  
J. Dinger ◽  
R. Fischer ◽  
K. Klingel ◽  
R. Kandolf ◽  
...  
Keyword(s):  
Parvovirus B19 ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6
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