scholarly journals Advances in Meniscal Tissue Engineering

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Umile Giuseppe Longo ◽  
Mattia Loppini ◽  
Francisco Forriol ◽  
Giovanni Romeo ◽  
Nicola Maffulli ◽  
...  

Meniscal tears are the most common knee injuries and have a poor ability of healing. In the last few decades, several techniques have been increasingly used to optimize meniscal healing. Current research efforts of tissue engineering try to combine cell-based therapy, growth factors, gene therapy, and reabsorbable scaffolds to promote healing of meniscal defects. Preliminary studies did not allow to draw definitive conclusions on the use of these techniques for routine management of meniscal lesions. We performed a review of the available literature on current techniques of tissue engineering for the management of meniscal tears.

2000 ◽  
Vol 13 (1-2) ◽  
pp. 19-28 ◽  
Author(s):  
Channarong Kasemkijwattana ◽  
Jacques Menetrey ◽  
Hideyuki Goto ◽  
Christopher Niyibizi ◽  
Freddie H Fu ◽  
...  

Nanomedicine ◽  
2022 ◽  
Author(s):  
Jihye Baek ◽  
Kwang Il Lee ◽  
Ho Jong Ra ◽  
Martin K Lotz ◽  
Darryl D D'Lima

Aim: To mimic the ultrastructural morphology of the meniscus with nanofiber scaffolds coupled with controlled growth factor delivery to modulate cellular performance for tissue engineering of menisci. Methods: The authors functionalized collagen nanofibers by conjugating heparin to the following growth factors for sustained release: PDGF-BB, TGF-β1 and CTGF. Results: Incorporating growth factors increased human meniscal and synovial cell viability, proliferation and infiltration in vitro, ex vivo and in vivo; upregulated key genes involved in meniscal extracellular matrix synthesis; and enhanced generation of meniscus-like tissue. Conclusion: The authors' results indicate that functionalizing collagen nanofibers can create a cell-favorable micro- and nanoenvironment and can serve as a system for sustained release of bioactive factors.


2002 ◽  
Vol 8 (1) ◽  
pp. 93-105 ◽  
Author(s):  
Chisa Hidaka ◽  
Clemente Ibarra ◽  
Jo A. Hannafin ◽  
Peter A. Torzilli ◽  
Mannix Quitoriano ◽  
...  

2014 ◽  
Author(s):  
Jennifer J Warnock ◽  
Gerd Bobe ◽  
Katja F. Duesterdieck-Zellmer

Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous synoviocytes from the affected stifle is an attractive cell source for tissue engineering replacement fibrocartilage. However, the diseased state of these cells may impede in vitro fibrocartilage formation. Synoviocytes from 12 osteoarthritic (“oaTSB”) and 6 normal joints (“nTSB”) were cultured as tensioned bioscaffolds and compared for their ability to synthesize fibrocartilage sheets. Gene expression of collagens type I and II were higher and expression of interleukin-6 was lower in oaTSB versus nTSB. Compared with nTSB, oaTSB had more glycosaminoglycan and alpha smooth muscle staining and less collagen I and II staining on histologic analysis, whereas collagen and glycosaminoglycan quantities were similar. In conclusion, osteoarthritic joint-origin synoviocytes can produce extracellular matrix components of meniscal fibrocartilage at similar levels to normal joint-origin synoviocytes, which makes them a potential cell source for canine meniscal tissue engineering.


2021 ◽  
Vol 8 (6) ◽  
pp. 35-39
Author(s):  
Shalya Raj ◽  
Rohit Ravinder ◽  
Preeti Mishra

The goal of gene-enhanced tissue engineering is to regenerate lost tissue by the local delivery of cells that have been genetically-enhanced to deliver physiologic levels of specific growth factors. The basis for this approach lies in the presence of a population of progenitor cells that can be induced, under the influence of these growth factors, to differentiate into the specific cells required for tissue regeneration, with guidance from local clues in the wound environment. Keywords: Gene therapy, Growth factor, Tissue engineering, Regeneration.


2014 ◽  
Author(s):  
Jennifer J Warnock ◽  
Gerd Bobe ◽  
Katja F. Duesterdieck-Zellmer

Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous synoviocytes from the affected stifle is an attractive cell source for tissue engineering replacement fibrocartilage. However, the diseased state of these cells may impede in vitro fibrocartilage formation. Synoviocytes from 12 osteoarthritic (“oaTSB”) and 6 normal joints (“nTSB”) were cultured as tensioned bioscaffolds and compared for their ability to synthesize fibrocartilage sheets. Gene expression of collagens type I and II were higher and expression of interleukin-6 was lower in oaTSB versus nTSB. Compared with nTSB, oaTSB had more glycosaminoglycan and alpha smooth muscle staining and less collagen I and II staining on histologic analysis, whereas collagen and glycosaminoglycan quantities were similar. In conclusion, osteoarthritic joint-origin synoviocytes can produce extracellular matrix components of meniscal fibrocartilage at similar levels to normal joint-origin synoviocytes, which makes them a potential cell source for canine meniscal tissue engineering.


2010 ◽  
Vol 88 (2) ◽  
pp. 326-332 ◽  
Author(s):  
Derek B. Fox ◽  
Jennifer J. Warnock ◽  
Aaron M. Stoker ◽  
Jill K. Luther ◽  
Mary Cockrell

Author(s):  
Dalip Pelinkovic ◽  
Joon Yung Lee ◽  
Nobuo Adachi ◽  
Johnny Huard

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