scholarly journals Bioelectric State and Cell Cycle Control of Mammalian Neural Stem Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Julieta Aprea ◽  
Federico Calegari
Keyword(s):  
Stem Cells ◽  
Membrane Potential ◽  
Ion Channels ◽  
Neural Stem Cells ◽  
Current Knowledge ◽  
Cell Cycle Control ◽  
Resting Membrane Potential ◽  
Excitable Cells ◽  
Proliferation And Differentiation

The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem cells. The importance of understanding stem cell contribution to tissue formation during embryonic development, adult homeostasis, and regeneration in disease has prompted many groups to study and manipulate the membrane potential of stem cells in a variety of systems. In this paper we aimed at summarizing the current knowledge on the role of ion channels and pumps in the context of mammalian corticogenesis with particular emphasis on their contribution to the switch of neural stem cells from proliferation to differentiation and generation of more committed progenitors and neurons, whose lineage during brain development has been recently elucidated.

Role of Ciliary Neurotrophic Factor in the Proliferation and Differentiation of Neural Stem Cells

2013 ◽  
Vol 37 (3) ◽  
pp. 587-592 ◽  
Author(s):  
Jun Ding ◽  
Zhili He ◽  
Juan Ruan ◽  
Zilong Ma ◽  
Ying Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Proliferation And Differentiation

The role of interleukin-6 (IL-6) in the proliferation and differentiation of human neural stem cells

2001 ◽  
Vol 29 (1) ◽  
pp. 1-14
Author(s):  
Stefano F. Pagano ◽  
Sabrina Lucchiari ◽  
Alessandra Bez ◽  
Dario Ponti ◽  
Marco Onofrj ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Interleukin 6 ◽  
Human Neural Stem Cells ◽  
Proliferation And Differentiation

scholarly journals Regulation of Cell Proliferation and Differentiation by PPARβ/δ

PPAR Research ◽  
2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
Rolf Müller ◽  
Markus Rieck ◽  
Sabine Müller-Brüsselbach
Keyword(s):  
Cell Proliferation ◽  
Current Knowledge ◽  
Cell Cycle Control ◽  
Peroxisome Proliferator ◽  
Oncogenic Signaling ◽  
Peroxisome Proliferator Activated Receptor ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Oncogenic Signaling Pathways

Peroxisome proliferator-activated receptor-β/δ(PPARβ/δ) is a ligand-activated transcription factor with essential functions in the regulation of lipid catabolism, glucose homeostasis, and inflammation, which makes it a potentially relevant drug target for the treatment of major human diseases. In addition, there is strong evidence that PPARβ/δmodulates oncogenic signaling pathways and tumor growth. Consistent with these observations, numerous reports have clearly documented a role for PPARβ/δin cell cycle control, differentiation, and apoptosis. However, the precise role of PPARβ/δin tumorigenesis and cell proliferation remains controversial. This review summarizes our current knowledge and proposes a model corroborating the discrepant data in this area of research.

scholarly journals Role of miRNA-146 in proliferation and differentiation of mouse neural stem cells

2015 ◽  
Vol 35 (5) ◽  
Author(s):  
Wei-Zhong Xiao ◽  
An-Qing Lu ◽  
Xin-Wei Liu ◽  
Zhe Li ◽  
Ying Zi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Notch 1 ◽  
Spontaneous Differentiation ◽  
Proliferation And Differentiation

In the present study, miR-146 promoted spontaneous differentiation of neural stem cells (NSCs), and this mechanism was influenced by miR-146, as well as its target (notch 1) and downstream gene.

Effect of low chloride on relaxation in hamster diaphragm muscle

1986 ◽  
Vol 61 (1) ◽  
pp. 180-184 ◽  
Author(s):  
S. A. Esau ◽  
N. Sperelakis
Keyword(s):  
Membrane Potential ◽  
Muscle Fatigue ◽  
Time Constant ◽  
Diaphragm Muscle ◽  
Resting Membrane Potential ◽  
Krebs Solution ◽  
Sarcolemmal Membrane ◽  
Cl Conductance

With muscle fatigue the chloride (Cl-) conductance of the sarcolemmal membrane decreases. The role of lowered Cl- conductance in the prolongation of relaxation seen with fatigue was studied in isolated hamster diaphragm strips. The muscles were studied in either a Krebs solution or a low Cl- solution in which half of the NaCl was replaced by Na-gluconate. Short tetanic contractions were produced by a 160-ms train of 0.2-ms pulses at 60 Hz from which tension (T) and the time constant of relaxation were measured. Resting membrane potential (Em) was measured using KCl-filled microelectrodes with resistances of 15–20 M omega. Mild fatigue (20% fall in tension) was induced by 24–25 tetanic contractions at the rate of 2/s. There was no difference in Em or T in the two solutions, either initially or with fatigue. The time constant of relaxation was greater in low Cl- solution, both initially (22 +/- 3 vs. 18 +/- 5 ms, mean +/- SD, P less than 0.05) and with fatigue (51 +/- 18 vs. 26 +/- 7 ms, P less than 0.005). Lowering of sarcolemmal membrane Cl- conductance appears to play a role in the slowing of relaxation of hamster diaphragm muscle seen with fatigue.

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