scholarly journals Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Winnie WY Ip ◽  
Waseem Qasim
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Morbidity And Mortality ◽  
Haematopoietic Stem Cell ◽  
Effective Strategy ◽  
Significant Morbidity ◽  
Hematopoietic Stem ◽  
Prevention And Treatment

Adenovirus (ADV) can cause significant morbidity and mortality in children following haematopoietic stem cell transplantation (HSCT), with an incidence of up to 27% and notable associated morbidity and mortality. T-cell depleted grafts and severe lymphopenia are major risk factors for the development of adenovirus disease after HSCT. Current antiviral treatments are at best virostatic and may have significant side effects. Adoptive transfer of donor-derived virus-specific T cells has been shown to be an effective strategy for the prevention and treatment of ADV infection after HSCT. Here we review progress in the field and present a pathway for the management of adenovirus in the posttransplant setting.

scholarly journals Effect of Denosumab on Bone Mineral Density of Hematopoietic Stem Cell Transplantation Recipients

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Chaiho Jeong ◽  
Hee-Je Kim ◽  
Seok Lee ◽  
Moo Il Kang ◽  
Jeonghoon Ha
Keyword(s):  
Bone Mineral Density ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Bone Mineral ◽  
Haematopoietic Stem Cell Transplantation ◽  
Haematopoietic Stem Cell ◽  
Solid Organ ◽  
Mineral Density ◽  
Hematopoietic Stem

Purpose. Denosumab is a monoclonal antibody that prevents the development of osteoclasts. The effect of denosumab in solid organ transplant recipients has been elucidated, but its effect in haematopoietic stem cell transplantation recipients has not been studied yet. The aim of this study was to determine the effectiveness and safety of denosumab in haematopoietic stem cell transplantation recipients. Methods. We retrospectively evaluated 33 female patients with osteoporosis (mean age 52.6 ± 9.8 years) following allogeneic haematopoietic stem cell transplantation. Patients were treated with denosumab every 6 months for 12 months. Changes in bone mineral density were evaluated for denosumab-treated patients in a 12-month interval after the first administration of denosumab. Results. Significant increases in bone mineral density were observed in all measured skeletal sites including 4.39 ± 6.63% in the lumbar spine (p=0.014), 3.11 ± 7.69% in the femoral neck (p=0.048), and 1.97 ± 6.01% in the total hip (p=0.138). The bone turnover marker serum cross-linked C-terminal telopeptide of type 1 collagen was decreased at 18 months (−51.6 ± 17.6%, p<0.001). No serious symptomatic hypocalcaemia was observed. Serious adverse drug reactions requiring drug discontinuation were not observed. Conclusion. Denosumab improved bone mineral density in haematopoietic stem cell transplantation recipients. The use of denosumab could be a good therapeutic option without causing severe adverse effects in recipients of haematopoietic transplantation.

scholarly journals Noninfectious pulmonary complications of haematopoietic stem cell transplantation

2020 ◽  
Vol 29 (156) ◽  
pp. 190119
Author(s):  
Samran Haider ◽  
Navin Durairajan ◽  
Ayman O. Soubani
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Infectious Complications ◽  
Bronchiolitis Obliterans Syndrome ◽  
Pulmonary Complications ◽  
Morbidity And Mortality ◽  
Haematopoietic Stem Cell ◽  
High Morbidity

Haematopoietic stem cell transplantation (HSCT) is an established treatment for a variety of malignant and nonmalignant conditions. Pulmonary complications, both infectious and noninfectious, are a major cause of morbidity and mortality in patients who undergo HSCT. Recent advances in prophylaxis and treatment of infectious complications has increased the significance of noninfectious pulmonary conditions. Acute lung injury associated with idiopathic pneumonia syndrome remains a major acute complication with high morbidity and mortality. On the other hand, bronchiolitis obliterans syndrome is the most challenging chronic pulmonary complication facing clinicians who are taking care of allogeneic HSCT recipients. Other noninfectious pulmonary complications following HSCT are less frequent. This review provides a clinical update of the incidence, risk factors, pathogenesis, clinical characteristics and management of the main noninfectious pulmonary complications following HSCT.

The prevention and treatment of cytomegalovirus infection in haematopoietic stem cell transplantation

2009 ◽  
Vol 58 (9) ◽  
pp. 1481-1488 ◽  
Author(s):  
Mark Tuthill ◽  
Frederick Chen ◽  
Samantha Paston ◽  
Hugo De La Peña ◽  
Sylvie Rusakiewicz ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Cytomegalovirus Infection ◽  
Haematopoietic Stem Cell ◽  
Prevention And Treatment

scholarly journals Acute abdomen after allogenic haematopoietic stem cell transplantation

2011 ◽  
Vol 3 (4) ◽  
pp. 32 ◽  
Author(s):  
Alessandro Crocoli ◽  
Daria Pagliara ◽  
Franco Locatelli ◽  
Alessandro Inserra
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Acute Abdomen ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Haematopoietic Stem Cell Transplantation ◽  
Conservative Therapy ◽  
Haematopoietic Stem Cell ◽  
Hematopoietic Stem

We report a case of a patient underwent allogenic hematopoietic stem cell transplantation complicated by acute colonic pseudo obstruction who require surgery after failure of conservative therapy.

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