scholarly journals Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Gwenneg Kerdivel ◽  
Denis Habauzit ◽  
Farzad Pakdel
Keyword(s):  
Synergistic Effects ◽  
Animal Health ◽  
Endocrine Disrupting Chemicals ◽  
Estrogen Signaling ◽  
Synthetic Chemicals ◽  
Endocrine Disrupting ◽  
And Function ◽  
Analytical Tools

In all vertebrate species, estrogens play a crucial role in the development, growth, and function of reproductive and nonreproductive tissues. A large number of natural or synthetic chemicals present in the environment and diet can interfere with estrogen signaling; these chemicals are called endocrine disrupting chemicals (EDCs) or xenoestrogens. Some of these compounds have been shown to induce adverse effects on human and animal health, and some compounds are suspected to contribute to diverse disease development. Because xenoestrogens have varying sources and structures and could act in additive or synergistic effects when combined, they have multiple mechanisms of action. Consequently, an important panel ofin vivoandin vitrobioassays and chemical analytical tools was used to screen, evaluate, and characterize the potential impacts of these compounds on humans and animals. In this paper, we discuss different molecular actions of some of the major xenoestrogens found in food or the environment, and we summarize the current models used to evaluate environmental estrogens.

scholarly journals Membrane filtration in water recycling: removal of natural hormones

2003 ◽  
Vol 3 (3) ◽  
pp. 155-160 ◽  
Author(s):  
L.D. Nghiem ◽  
A.I. Schäfer ◽  
T.D. Waite
Keyword(s):  
Membrane Filtration ◽  
Endocrine Disrupting Chemicals ◽  
In Vivo Studies ◽  
Water Recycling ◽  
Endocrine Disrupting ◽  
Adsorptive Behavior ◽  
Stirred Cell ◽  
Natural Hormones

Recent detections of endocrine-disrupting chemicals (EDCs) in effluent are of great concern to sections of the community associated with the issue of water recycling. In vitro and in vivo studies by many researchers have confirmed the impacts of EDCs on trout at the common concentration encountered in sewage effluent. Amongst many types of EDCs the impacts of steroid estrogens such as estrone, estradiol (natural hormones) and ethinylestradiol (a synthetic hormone) are prominent as they have far higher endocrine-disrupting potency than other synthetic EDCs. Given the continuous developments in membrane technology, tertiary treatment using membrane processes has been identified as a promising technology to provide a safeguard to water recycling practice and to protect the environment. This paper investigates retention and adsorptive behavior of the natural hormones estrone and estradiol by two commercial low-pressure nanofiltration membranes TFC-SR2 and TFC-S, using dead end stirred cell systems. The removal phenomena of estradiol are similar to that of estrone. pH has been found to significantly influence the adsorption of estrone and estradiol by the membranes, presumably due to hydrogen bonding. This adsorption is critical in the risk of possible release of such hormones to the product waters. Total adsorbed amounts were calculated for standard membrane elements and are indeed important.

In vivo and in vitro Screening of Endocrine Disrupting Chemicals with Estrogenic activity in Japanese Quail

2005 ◽  
Vol 16 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Kiyoshi Shimada ◽  
Yonju Ha ◽  
Akira Tsukada ◽  
Noboru Saito ◽  
Shinobu Maekawa ◽  
...  
Keyword(s):  
Japanese Quail ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting

Endocrine potency of wastewater: Contents of endocrine disrupting chemicals and effects measured by in vivo and in vitro assays

2010 ◽  
Vol 30 (2) ◽  
pp. 413-426 ◽  
Author(s):  
Kresten Ole Kusk ◽  
Tanja Krüger ◽  
Manhai Long ◽  
Camilla Taxvig ◽  
Anne E. Lykkesfeldt ◽  
...  
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
In Vitro Assays ◽  
Endocrine Disrupting

scholarly journals Impacts of Bisphenol A and Ethinyl Estradiol on Male and Female CD-1 Mouse Spleen

2017 ◽  
Author(s):  
Robin B. Gear ◽  
Scott M. Belcher
Keyword(s):  
Immune System ◽  
Bisphenol A ◽  
Ethinyl Estradiol ◽  
Endocrine Disrupting Chemicals ◽  
Wide Spread ◽  
Male And Female ◽  
Synthetic Chemicals ◽  
Endocrine Disrupting ◽  
The Impact

ABSTRACTThe endocrine disruptor bisphenol A (BPA) and the pharmaceutical 17α-ethinyl estradiol (EE) are synthetic chemicals with estrogen-like activities. Despite ubiquitous human exposure to BPA, and the wide-spread clinical use of EE as oral contraceptive adjuvant, the impact of these estrogenic endocrine disrupting chemicals (EDCs) on the immune system is unclear. Here we report results of in vivo dose response studies that analyzed the histology and microstructural changes in the spleen of adult male and female CD-1 mice exposed to 4 to 40,000 μg/kg/day BPA or 0.02 to 2 μg/kg/day EE from conception until 12-14 weeks of age. Results of that analysis indicate that both BPA and EE have dose- and sex-specific impacts on the cellular and microanatomical structures of the spleens that reveal minor alterations in immunomodulatory and hematopoietic functions. These findings support previous studies demonstrating the murine immune system as a sensitive target for estrogens, and that oral exposures to BPA and EE can have estrogen-like immunomodulatory affects in both sexes.

scholarly journals Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review

2021 ◽  
Vol 18 (4) ◽  
pp. 1464 ◽  
Author(s):  
Saira Amir ◽  
Syed Tahir Abbas Shah ◽  
Charalampos Mamoulakis ◽  
Anca Oana Docea ◽  
Olga-Ioanna Kalantzi ◽  
...  
Keyword(s):  
Androgen Receptors ◽  
Endocrine Disrupting Chemicals ◽  
Gonadal Development ◽  
Methylation Pattern ◽  
Estrogen Signaling ◽  
Sex Characteristics ◽  
In Silico Studies ◽  
The Impact

Increasing contamination of the environment by toxic compounds such as endocrine disrupting chemicals (EDCs) is one of the major causes of reproductive defects in both sexes. Estrogen/androgen pathways are of utmost importance in gonadal development, determination of secondary sex characteristics and gametogenesis. Most of the EDCs mediate their action through respective receptors and/or downstream signaling. The purpose of this review is to highlight the mechanism by which EDCs can trigger antagonistic or agonistic response, acting through estrogen/androgen receptors causing reproductive defects that lead to infertility. In vitro, in vivo and in silico studies focusing on the impact of EDCs on estrogen/androgen pathways and related proteins published in the last decade were considered for the review. PUBMED and PUBCHEM were used for literature search. EDCs can bind to estrogen receptors (ERα and ERβ) and androgen receptors or activate alternative receptors such as G protein-coupled receptors (GPCR), GPR30, estrogen-related receptor (ERRγ) to activate estrogen signaling via downstream kinases. Bisphenol A, dichlorodiphenyltrichloroethane, dichlorodiphenyldichloroethylene, polychlorinated biphenyls and phthalates are major toxicants that interfere with the normal estrogen/androgen pathways leading to infertility in both sexes through many ways, including DNA damage in spermatozoids, altered methylation pattern, histone modifications and miRNA expression.

scholarly journals In vitro ovarian culture system provides insight into the mechanism underlying follicle assembly in vivo

Development ◽  
2021 ◽  
pp. dev.197459
Author(s):  
Ren Tanimoto ◽  
Kiyono Sekii ◽  
Kanako Morohaku ◽  
Jianzhen Li ◽  
David Pepin ◽  
...  
Keyword(s):  
Fetal Liver ◽  
Endocrine Disrupting Chemicals ◽  
Ectopic Expression ◽  
Perinatal Period ◽  
Primordial Follicles ◽  
Estrogen Exposure ◽  
Endocrine Disrupting ◽  
Insight Into

In mammals, primordial follicles assembled in fetuses or during infancy constitute the oocyte resources for life. Exposure to 17beta-estradiol and phytogenic or endocrine-disrupting chemicals during pregnancy and/or the perinatal period leads to the failure of normal follicle formation. However, the mechanisms underlying estrogen-mediated abnormal follicle formation and physiological follicle formation in the presence of endogenous natural estrogen are not well-understood. Here, we reveal that estrogen receptor 1, activated by estrogen, binds to the 5′ region of the anti-Mullerian hormone (Amh) gene and upregulates its transcription before follicle formation in cultured mouse fetal ovaries. Ectopic expression of AMH protein was observed in pregranulosa cells of these explants. Furthermore, AMH addition to the culture medium inhibited normal follicle formation. Conversely, alpha-fetoprotein (AFP) produced in fetal liver reportedly blocks estrogen action, although its role in follicle formation is unclear. We further demonstrated that AFP addition to the medium inhibited ectopic AMH expression via estrogen, leading to successful follicle formation in vitro. Collectively, our in vitro experiments suggest that upon estrogen exposure, the integrity of follicle assembly in vivo is ensured by AFP.

Zearalenone and its metabolites as endocrine disrupting chemicals

2010 ◽  
Vol 3 (4) ◽  
pp. 385-401 ◽  
Author(s):  
M. Metzler ◽  
E. Pfeiffer ◽  
A. Hildebrand
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Carcinogenic Activity ◽  
Present Evidence ◽  
Cereal Products ◽  
Numerous Species ◽  
Endocrine Disrupting ◽  
The World ◽  
Acid Lactone

Zearalenone (ZEA) is a macrocyclic β-resorcylic acid lactone produced by numerous species of Fusarium. It frequently contaminates corn and cereal products in many regions of the world. The biological activity of ZEA is dominated by its pronounced oestrogenicity, which is even enhanced in certain reductive metabolites. This review updates the metabolism in fungi, plants and mammalian systems, as well as the pharmacokinetics of ZEA. The present evidence for the hormonal effects of the parent mycoestrogen and some of its metabolites in vitro and in farm and experimental animals in vivo is reviewed, together with its association with endocrine-disruptive effects in humans. Possible mechanisms of the oestrogenic and carcinogenic activity of ZEA are discussed and future areas of research proposed.

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