Novel Organotin(IV) Schiff Base Complexes with Histidine Derivatives: Synthesis, Characterization, and Biological Activity

Five novel tin Schiff base complexes with histidine analogues (derived from the condensation reaction between L-histidine and 3,5-di-tert-butyl-2-hydroxybenzaldehyde) have been synthesized and characterized. Characterization has been completed by IR and high-resolution mass spectroscopy, 1D and 2D solution NMR (1H,13C and119Sn), as well as solid state119Sn NMR. The spectroscopic evidence shows two types of structures: a trigonal bipyramidal stereochemistry with the tin atom coordinated to five donating atoms (two oxygen atoms, one nitrogen atom, and two carbon atoms belonging to the alkyl moieties), where one molecule of ligand is coordinated in a three dentate fashion. The second structure is spectroscopically described as a tetrahedral tin complex with four donating atoms (one oxygen atom coordinated to the metal and three carbon atoms belonging to the alkyl or aryl substituents), with one molecule of ligand attached. The antimicrobial activity of the tin compounds has been tested against the growth of bacteriain vitroto assess their bactericidal properties. While pentacoordinated compounds1,2, and3are described as moderate effective to noneffective drugs against both Gram-positive and Gram-negative bacteria, tetracoordinated tin(IV) compounds4and5are considered as moderate effective and most effective compounds, respectively, against the methicillin-resistantStaphylococcus aureusstrains (Gram-positive).

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Targeting ctDNA binding and elaborated in-vitro assessments concerning novel Schiff base complexes: Synthesis, characterization, DFT and detailed in-silico confirmation

Journal of Molecular Liquids ◽

10.1016/j.molliq.2020.114977 ◽

2021 ◽

Vol 322 ◽

pp. 114977

Author(s):

Ahmed M. Abu-Dief ◽

Nashwa M. El-Metwaly ◽

Seraj Omar Alzahrani ◽

Afrah M. Bawazeer ◽

Saad Shaaban ◽

...

Keyword(s):

Schiff Base ◽

In Silico ◽

Schiff Base Complexes

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Synthesis,Characterization and Evaluation of Biological Activity of Sulfonylhydrazide-Schiff Base" (E)- N’-(2,5-dimethoxybenzalidene) naphthalene-2-sulfonohydrazide"

مجلة جامعة فلسطين التقنية للأبحاث ◽

10.53671/pturj.v8i1.83 ◽

2020 ◽

Vol 8 (1) ◽

pp. 01-11

Author(s):

Sameer Amereih ◽

Abd Daraghmeh ◽

Ismail Warad ◽

Mohammed Al-Nuri

Keyword(s):

Schiff Base ◽

Inhibitory Concentration ◽

Condensation Reaction ◽

Gram Negative Bacteria ◽

Biological Applications ◽

Bacteriostatic Effect ◽

1H And 13C Nmr ◽

13C Nmr Analysis ◽

Ft Ir

Condensation reaction of naphthalene -2-Sulfonylhydrazide, as starting material with 2,5-dimethoxy benzaldehyde was used to produce (E)-N’-(2,5-dimethoxybenzalidene)naphthalene-2-sulfonohydrazide. The Schiff base product was isolated, purified and then spectrally characterized via UV-Vis, GC/MS, FT-IR, 1H and 13C NMR analysis, where strong evidences confirmed the formation of the desired product. Antimicrobial activity of Schiff base product was evaluated in vitro against several types of bacteria such as: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae and MRSA by Minimum Inhibitory Concentration (MIC) test using tetracycline (TE) as a standard antibiotic. The tests showed a promising bacteriostatic effect of this compound against gram negative bacteria such as P. aeruginosa and K. pneumoniae, such character is valuable for biological applications.

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In silico DNA topo IIβ binding and in vitro DNA interaction, anti-proliferative, and anti-bacterial activities of two new ternary Copper (II) schiff base complexes

Chemical Data Collections ◽

10.1016/j.cdc.2018.11.001 ◽

2018 ◽

Vol 17-18 ◽

pp. 419-430 ◽

Cited By ~ 3

Author(s):

Pulimamidi Rabindra Reddy ◽

Merugu Kumara Swamy ◽

Battu Satyanarayana

Keyword(s):

Schiff Base ◽

In Silico ◽

Dna Interaction ◽

Schiff Base Complexes

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Efficient Synthesis, In-Vitro Antioxidant, Anticancer and Molecular Docking Studies of Bidentate Schiff Base Complexes of Vo(Ii) and Zn(Ii) by Green Route Method

SSRN Electronic Journal ◽

10.2139/ssrn.3696915 ◽

2020 ◽

Author(s):

R. SELVARANI ◽

S. Balasubramaniyan ◽

C. VEERAVEL ◽

R. Geetha

Keyword(s):

Schiff Base ◽

Molecular Docking ◽

Docking Studies ◽

Schiff Base Complexes ◽

Efficient Synthesis ◽

Molecular Docking Studies ◽

Green Route

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Practical and computational studies on novel Schiff base complexes derived from green synthesis approach: Conductometry as well as in-vitro screening supported by in-silico study

Journal of Molecular Liquids ◽

10.1016/j.molliq.2020.114116 ◽

2020 ◽

Vol 319 ◽

pp. 114116 ◽

Cited By ~ 2

Author(s):

Reem Shah ◽

Hanadi Katouah ◽

Anas A. Sedayo ◽

Matokah Abualnaja ◽

Meshari M. Aljohani ◽

...

Keyword(s):

Schiff Base ◽

Green Synthesis ◽

In Silico ◽

Schiff Base Complexes ◽

Computational Studies ◽

In Vitro Screening ◽

In Silico Study ◽

Synthesis Approach

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Synthesis, Spectroscopic, Molecular Structure, and Antibacterial Studies of Dibutyltin(IV) Schiff Base Complexes Derived from Phenylalanine, Isoleucine, and Glycine

Bioinorganic Chemistry and Applications ◽

10.1155/2014/716578 ◽

2014 ◽

Vol 2014 ◽

pp. 1-12 ◽

Cited By ~ 17

Author(s):

Har Lal Singh ◽

Jangbhadur Singh

Keyword(s):

Amino Acids ◽

Schiff Base ◽

Schiff Bases ◽

Molar Conductance ◽

Schiff Base Complexes ◽

Spectral Studies ◽

E Coli ◽

Elemental Analyses ◽

In Vitro Antibacterial Activity

New series of organotin(IV) complexes and Schiff bases derived from amino acids have been designed and synthesized from condensation of1H-indole-2,3-dione, 5-chloro-1H-indole-2,3-dione, andα-amino acids (phenylalanine, isoleucine, and glycine). All compounds are characterized by elemental analyses, molar conductance measurements, and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance (1H,13C, and119Sn NMR) spectral studies. The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2]. Elemental analyses and NMR spectral data of the ligands with their dibutyltin(IV) complexes agree with their proposed distorted octahedral structures. Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus,Staphylococcusspp.) and Gram-negative (E. coli,Klebsiellaspp.) bacteria. The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

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Synthesis, Antimicrobial Screening, Homology Modeling, and Molecular Docking Studies of a New Series of Schiff Base Derivatives as Prospective Fungal Inhibitor Candidates

Molecules ◽

10.3390/molecules24183250 ◽

2019 ◽

Vol 24 (18) ◽

pp. 3250 ◽

Cited By ~ 4

Author(s):

Yahya Toubi ◽

Farid Abrigach ◽

Smaail Radi ◽

Faiza Souna ◽

Abdelkader Hakkou ◽

...

Keyword(s):

Schiff Base ◽

Homology Modeling ◽

Condensation Reaction ◽

Docking Studies ◽

Antifungal Effect ◽

1H And 13C Nmr ◽

Schiff Base Derivatives ◽

Ft Ir ◽

Antibacterial And Antifungal

Twelve new Schiff base derivatives have been prepared by the condensation reaction of different amino substituted compounds (aniline, pyridin-2-amine, o-toluidine, 2-nitrobenzenamine, 4-aminophenol, and 3-aminopropanol) and substituted aldehydes such as nicotinaldehyde, o,m,p-nitrobenzaldehyde, and picolinaldehyde in ethanol using acetic acid as a catalyst. The envisaged structures of the all the synthesized ligands have been confirmed on the basis of their spectral analysis FT-IR, mass spectroscopy, 1H- and 13C-NMR. In vitro screening of their antibacterial and antifungal potential against Escherichia coli bacterium and Fusarium oxysporum f.sp albedinis (F.o.a) fungus, respectively, revealed that all the ligands showed no significant antibacterial activity, whereas most of them displayed good antifungal activity. Homology modeling and docking analysis were performed to explain the antifungal effect of the most and least active compound against two F.o.a fungus proteins.

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Synthesis and Spectral Studies of 4,4′-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2- methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

Asian Journal of Chemistry ◽

10.14233/ajchem.2020.22703 ◽

2020 ◽

Vol 32 (7) ◽

pp. 1768-1772

Author(s):

Anita Rani ◽

Manoj Kumar ◽

Hardeep Singh Tuli ◽

Zahoor Abbas ◽

Vinit Prakash

Keyword(s):

Schiff Base ◽

Transition Metal ◽

Metal Complexes ◽

Transition Metal Complexes ◽

Schiff Base Ligand ◽

Biological Activities ◽

Condensation Reaction ◽

Analytical Techniques ◽

Spectral Studies

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

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