Structure of N-(3,4-Dimethoxyphenyl)pyrido[3′,2′:4,5]-thieno[3,2-d]pyrimidin-4-amine, a New Inhibitor of CLK1 and DYRK1A Kinases
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The complete crystal structure of N-(3,4-dimethoxyphenyl)pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amine, synthesized via a Dimroth rearrangement and designed as new inhibitor of CLK1 and DYRK1A kinases, was established by a single-crystal X-ray diffraction. The crystal is orthorhombic, space group Pca21; a = 13.1593 (9), b = 13.9823 (10), c=8.5403 (7) Å, α=β=γ=90°, V = 1571.4 (2) Å3, and Z=4, C17H14N4O2S. Solid-state data could be used to enlighten the biological mechanism of action.
2017 ◽
Vol 72
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pp. 983-988
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1994 ◽
Vol 49
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pp. 1263-1266
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1989 ◽
Vol 44
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pp. 135-138
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2007 ◽
Vol 62
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pp. 1-4
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