scholarly journals The Link between Ankylosing Spondylitis, Crohn’s Disease,Klebsiella, and Starch Consumption

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Taha Rashid ◽  
Clyde Wilson ◽  
Alan Ebringer

Both ankylosing spondylitis (AS) and Crohn’s disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen,Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these diseases. Increased starch consumptions by genetically susceptible individuals such as those possessing HLA-B27 allelotypes could trigger the disease in both AS and CD by enhancing the growth and perpetuation of theKlebsiellamicrobes in the bowel. Exposure to increased levels of these microbes will lead to the production of elevated levels of anti-Klebsiellaantibodies as well as autoantibodies against cross-reactive self-antigens with resultant pathological lesions in the bowel and joints. Hence, a decrease of starch-containing products in the daily dietary intake could have a beneficial therapeutic effect on the disease especially when used in conjunction with the currently available medical therapies in the treatment of patients with AS and CD.

1990 ◽  
Vol 4 (8) ◽  
pp. 497-502 ◽  
Author(s):  
JM Gilvarry ◽  
F Keeling ◽  
O Fitzgerald ◽  
JF Fielding

A controlled prospective study was undertaken to determine the incidence and characteristic features of peripheral arthritis, sacroiliitis, ankylosing spondylitis and hypertrophic osteoarthropathy in a group of patients with Crohn's disease, and to define the relationship of such arthritides with disease site, duration and activity. Peripheral arthritis occurred in 14.5% of the patients; it was not seen in the control group. This arthritis, which tended to be pauciarticular, was more common in females with large bowel disease and post dated the bowel symptoms in all but one patient. There was close correlation with disease activity. Radiographic sacroiliitis occurred in 12.7% of the patients and ankylosing spondylitis in 7.3%; neither of these were seen in the control group. Sacroiliitis was more common in females and showed no correlation with either disease activity or human lymphocyte antigen (HLA) B27. Ankylosing spondylitis was seen equally in males and females and showed close correlation with both disease activity and HLA B27. Hypertrophic osteoarthropathy occurred in 9.1% of patients. It was not seen in the control group. All patients were asymptomatic. It showed no correlation with disease activity, finger clubbing, age of disease onset, or HLA B27.


1989 ◽  
Vol 118 (1) ◽  
pp. 174-176 ◽  
Author(s):  
Steve Burdick ◽  
Donald D. Tresch ◽  
Richard A. Komokowski

2006 ◽  
Vol 26 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Alan Ebringer ◽  
Taha Rashid ◽  
Harmale Tiwana ◽  
Clyde Wilson

1997 ◽  
Vol 17 (1) ◽  
pp. 11-16 ◽  
Author(s):  
H. Tiwana ◽  
C. Wilson ◽  
R. S. Walmsley ◽  
A. J. Wakefield ◽  
M. S. N. Smith ◽  
...  

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