scholarly journals Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion

2013 ◽  
Vol 2013 ◽  
pp. 1-2 ◽  
Author(s):  
Glen J. Weiss ◽  
Agnes K. Liman ◽  
Jeffrey Allen ◽  
Philip Y. Cheung ◽  
Rajesh N. Kukunoor
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Symptom Relief ◽  
Growth Factor Receptor ◽  
Gi Tract ◽  
Exon 19 Deletion ◽  
Epidermal Growth ◽  
Exon 19

We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity.

scholarly journals Detection of clinically relevant epidermal growth factor receptor pathway mutations in circulating cell-free tumor DNA using next generation sequencing in squamous cell carcinoma lung

2019 ◽  
Vol 08 (04) ◽  
pp. 247-249
Author(s):  
Kanakasetty Babu Govind ◽  
Deepak Koppaka ◽  
Lokanatha Dasappa ◽  
Linu Abraham Jacob ◽  
Suresh M.C. Babu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Braf Mutations ◽  
Lung Cancer Patients ◽  
Epidermal Growth ◽  
Generation Sequencing

Abstract Background: Limited repertoires of targets are available in the management of squamous cell carcinoma lung. In this study, we analyzed epidermal growth factor receptor (EGFR), RAS, BRAF mutations in lung cancer patients of squamous cell histology using next-generation sequencing (NGS) on the circulating cell-free DNA (cf-DNA). Materials and Methods: In this prospective observational study, patients with squamous cell carcinoma lung, either newly diagnosed or having a progressive disease on prior therapy were eligible. Cf-DNA was extracted from peripheral blood and analyzed for EGFR, KRAS, NRAS, and BRAF mutations using NGS. Results: Sixteen patients were enrolled over a period of 1 month. The mean cf-DNA quantity extracted from the plasma was 96.5 ng (range, 15–200 ng). Eight clinically relevant mutations in the EGFR pathway were identified. These include Exon 21 mutations in 4 patients, Exon 20 mutation in onepatient, complex mutations with coexisting Exon 21 and Exon18 in one patient and KRAS Exon 2 mutations in two patients. Conclusion: cf-DNA is a minimally invasive technique for detection of clinically relevant mutations in lung cancer patients. The use of novel advanced techniques such as NGS may help in detecting EGFR pathway mutations in patients with squamous cell carcinoma lung.

Epidermal growth factor receptor as an adverse survival predictor in squamous cell carcinoma of the penis

2017 ◽  
Vol 61 ◽  
pp. 97-104 ◽  
Author(s):  
Alice Muglia Thomaz da Silva Amancio ◽  
Isabela Werneck da Cunha ◽  
José Ivanildo Neves ◽  
Josiane da Silva Quetz ◽  
Dirce Maria Carraro ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Epidermal Growth ◽  
Survival Predictor

scholarly journals β-Catenin/CBP inhibition alters epidermal growth factor receptor fucosylation status in oral squamous cell carcinoma

2020 ◽  
Vol 16 (3) ◽  
pp. 195-209 ◽  
Author(s):  
Kevin Brown Chandler ◽  
Khalid A. Alamoud ◽  
Vanessa L. Stahl ◽  
Bach-Cuc Nguyen ◽  
Vinay K. Kartha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Oral Cancer ◽  
Epidermal Growth Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Epidermal Growth

Genomic and structural analyses reveal that β-catenin/CBP signaling represses epidermal growth factor receptor (EGFR) N-glycan antennary fucosylation in oral cancer.

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