Comparative Plasma Exposure of Albendazole after Administration of Rapidly Disintegrating Tablets in Dogs
Keyword(s):
The main objectives of this study were (a) to evaluate thein vitroperformance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study thein vivopharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. Thein vivoassays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
Keyword(s):
2021 ◽
Vol 596
◽
pp. 120222
Keyword(s):
2017 ◽
Vol 09
(03)
◽
Keyword(s):
2008 ◽
Vol 34
(11)
◽
pp. 1209-1218
◽
Keyword(s):
2019 ◽
Vol 22
◽
pp. 221-246
◽
2018 ◽
Vol 4
(4)
◽
pp. 523-531
2020 ◽
Vol 13
(5)
◽
pp. 5102-5109