Reduced defect recovery in self-ion damaged W due to simultaneous deuterium exposure during annealing

Deuterium (D) plasma exposure during annealing of self-ion damaged tungsten (W) is shown to exhibit reduced defect recovery when compared to annealing without D plasma exposure. In these experiments, samples were first damaged with 20 MeV W ions. Next, samples were annealed either with or without simultaneous D2 plasma exposure. The simultaneous annealed samples were first decorated by D2 plasma at 383 K prior to ramping up to an annealing temperature of 473, 573, 673, or 773 K and held for 1 hour with concurrent plasma exposure. The vacuum annealed samples each had a corresponding temperature history but without D$_2$ plasma treatment. Finally, all samples were exposed to D2 plasma at 383 K to decorate any remaining defects. Nuclear reaction analysis (NRA) and thermal desorption spectroscopy (TDS) shows that the simultaneous plasma-exposed and annealed samples exhibited virtually no defect recovery at annealing temperatures of up to 673 K, and had higher D retention than found in the vacuum annealed samples. TDS results indicate that only the lowest detrapping energy defects recover at an 773~K anneal for the simultaneous plasma annealed samples, while the vacuum annealed samples showed defect recovery at all anneal temperatures. This experiment clearly demonstrates that D occupied defects can significantly reduce or eliminate defect annealing in W, and is consistent with the existence of synergistic plasma exposure/displacement damage effects in fusion-energy relevant plasma facing materials.

In-situ measurements of low energy D plasma-driven permeation through He pre-damaged W

Experiments concerning the effect of helium (He) plasma exposure on deuterium (D) plasma-driven permeation (PDP) through tungsten (W) foils in a linear plasma facility has been performed. 0.05 mm thick W foils were exposed to ~2×1020 m-2s-1 He plasma with various fluences at 883 K. After He irradiating, D permeation tests were performed for the samples and retention was also measured by high-resolution thermal desorption spectroscopy (TDS). It was observed that He pre-irradiation resulted in a significant reduction of D permeation and retention in W. Microstructure observation indicated that the surfaces of samples after He irradiation turned rough and He nanobubbles were formed near the surface. The defective structure including He nanobubbles very likely enhances D reemission and accordingly reduces the permeation and retention in He pre-irradiated W.

Surface Modification of Commingled Flax/PP and Flax/PLA Fibres by Silane or Atmospheric Argon Plasma Exposure to Improve Fibre–Matrix Adhesion in Composites

Challenges faced by natural fibre-reinforced composites include poor compatibility between hydrophilic fibres such as flax and hydrophobic polymeric matrices such as polypropylene (PP) or poly(lactic acid) (PLA), and their inherent flammability. The former promotes weak interfacial adhesion between fibre and matrix, which may be further compromised by the addition of a flame retardant. This paper investigates the effect that the added flame retardant (FR), guanylurea methylphosphonate (GUP) and selected surface treatments of commingled flax and either PP or PLA fabrics have on the fibre/matrix interfacial cohesive forces in derived composites. Surface treatments included silanisation and atmospheric plasma flame exposure undertaken both individually and in sequence. 1-, 2- and 8-layered composite laminates were examined for their tensile, peeling and flexural properties, respectively, all of which yield measures of fibre-matrix cohesion. For FR-treated Flax/PP composites, maximum improvement was obtained with the combination of silane (using vinyltriethoxysilane) and plasma (150 W) treatments, with the highest peeling strength and flexural properties. However, for FR-treated Flax/PLA composites, maximum improvement in both properties occurred following 150 W plasma exposure only. The improvements in physical properties were matched by increased fibre-matrix adhesion as shown in SEM images of fractured laminates in which fibre-pullout had been eliminated.

Short-term retention in metallic PFCs: modelling in view of mass spectrometry and LIBS

Based on the conventional model of hydrogen retention in plasma-facing components, the question of hydrogen outgassing during and after plasma exposure is addressed in relation to mass spectrometry and laser-induced breakdown sprectroscopy (LIBS) measurements. Fundamental differences in retention and release data acquired by LIBS and by mass spectrometry are described analytically and by modelling. Reaction-diffusion simulations are presented that demonstrate possible thermal outgassing effects caused by LIBS. Advantages and limitations of LIBS as a tool for analysis of short term retention are discussed.

Influence of Potable Water Origin on the Physicochemical and Antimicrobial Properties of Plasma Activated Water

The interaction between a cold gas plasma and water creates a plasma activated liquid, a solution rich in highly reactive chemical species. Such liquids have garnered considerable attention due to their powerful antimicrobial properties and ease of production. In this contribution, air plasma was used to activate potable water samples from five different countries, including the UK, France, Norway, Slovenia and Palestine. All water samples had an initial pH in the range of 7.9 to 8.2, following plasma activation samples from the UK and Norway reached a pH below 3, whereas water from France and Palestine remained stable at 8. The concentration of NO3− increased in all samples, reaching a maximum concentration of 3 mM after 25 min plasma exposure; whereas the concentration of NO2− showed a non-linear dependence with exposure time, reaching between 10 and 25 µM after 25 min of exposure. To demonstrate the impact of water origin on the antimicrobial potential of each solution, the inactivation of Staphylococcus aureus and Escherichia coli was considered. It was found that activated water from the UK was capable of achieving > 6 log reduction, whereas water from Palestine was only able to achieve a 0.4 log reduction, despite both liquids receiving an identical plasma exposure. The study demonstrates the importance of initial water composition on the level of plasma activation, indicating that additional purification steps prior to activation may be necessary to ensure efficacy and repeatability.

First plasma exposure of a pre-damaged ITER-like plasma facing unit in the WEST tokamak: procedure for the PFU preparation and lessons learnt

The evaluation of the impact of plasma-facing components (PFCs) damage on subsequent plasma operation is an important issue for ITER. During the first phase of operation of WEST, a few ITER like divertor plasma-facing units (PFUs) have been installed on the lower divertor. One PFU was pre-damaged under electron beam gun thermal loading, before its installation in WEST, and the subsequent evolution of the damage was studied after the WEST plasma exposure. This paper presents the procedure followed to get the pre-damaged PFU. It consists in the characterization of the response of tungsten samples representative of WEST PFU under high heat flux (HHF) loading, the selection of damage (namely small cracks, crack network, crack network and W melt droplets). Finally, according to the WEST plasma loading conditions, the blocks with damage within the PFU and the position of the pre-damaged PFU on the WEST lower divertor are attributed. The first results obtained after an initial plasma exposure in WEST lead to assess, as expected with regard to the heat loading conditions, that no major surface aspect modification was found. This result emphasized the possibility to implement as pre-damage some small local droplets of melted tungsten in a high heat loaded zone for a future WEST experimental campaign.

Predictors of Efavirenz Plasma Exposure, Auto-Induction Profile, and Effect of Pharmacogenetic Variations among HIV-Infected Children in Ethiopia: A Prospective Cohort Study

(1) Background: Efavirenz plasma concentration displays wide between-patient variability partly due to pharmacogenetic variation and autoinduction. Pediatric data on efavirenz pharmacokinetics and the relevance of pharmacogenetic variation are scarce, particularly from sub-Saharan Africa, where >90% of HIV-infected children live and population genetic diversity is extensive. We prospectively investigated the short- and long-term effects of efavirenz auto-induction on plasma drug exposure and the influence of pharmacogenetics among HIV-infected Ethiopian children. (2) Method: Treatment-naïve HIV-infected children aged 3–16 years old (n = 111) were enrolled prospectively to initiate efavirenz-based combination antiretroviral therapy (cART). Plasma efavirenz concentrations were quantified at 4, 8, 12, 24, and 48 weeks of cART. Genotyping for CYP2B6, CYP3A5, UGT2B7, ABCB1, and SLCO1B1 common functional variant alleles was performed. (3) Results: The efavirenz plasma concentration reached a peak at two months, declined by the 3rd month, and stabilized thereafter, with no significant difference in geometric mean over time. On average, one-fourth of the children had plasma efavirenz concentrations ≥4 µg/mL. On multivariate analysis, CYP2B6*6 and ABCB1c.3435 C > T genotypes and low pre-treatment low-density lipoprotein (LDL) were significantly associated with higher plasma efavirenz concentration regardless of treatment duration. Duration of cART, sex, age, nutritional status, weight, and SLCO1B, CYP3A5, UGT2B7, and ABCB1 rs3842 genotypes were not significant predictors of efavirenz plasma exposure. (4) Conclusion: Pre-treatment LDL cholesterol and CYP2B6*6 and ABCB1c.3435 C > T genotypes predict efavirenz plasma exposure among HIV-infected children, but treatment-duration-dependent changes in plasma efavirenz exposure due to auto-induction are not statistically significant.

Effects of plasma treatment parameters on the adsorption properties of tin dioxide-based nanomaterials

We have studied the effect of nitrogen plasma exposure on the adsorption properties of SnO2-based nanomaterials synthesized by the sol-gel method. We have established the correlation between the adsorption properties and plasma treatment parameters. The scanning electron microscopy has confirmed integrity violation of the original structure of nanomaterials and an increase in their specific surface area with high-power plasma source.

The More, the Merrier…? Antipsychotic Polypharmacy Treatment Strategies in Schizophrenia From a Pharmacology Perspective

Antipsychotic polypharmacy/drug combination treatment (APP) is a remarkably common practice in the schizophrenia context, given the lack of general support in treatment Guidelines. There is also a vast literature on APP outcomes, but a paucity of high-quality evidence-based data to guide and optimize adequate use of APP. This seems particularly true regarding many pharmacology-based considerations involved in APP treatment strategies. This paper first briefly summarizes clinical literature related to the use of APP. Against this backdrop, the pharmacological target profile features are then described of frequently used antipsychotic agents, in relation to estimated free plasma exposure levels at clinically efficacious dosing. APP strategies based on the properties of these drugs are then scrutinized and gauged within the background literature framework. The anticipated usefulness of APP from the pharmacological standpoint is detailed regarding efficacy, adverse effect (AE)/tolerability, and safety perspective, including why, when, and how it may be used to its advantage. For the purpose, a number of theoretically beneficial combinations as well as instances with suboptimal—and even futile—APP approaches are exemplified and discussed from the rational pharmacodynamic and pharmacokinetic pros and cons point-of-view. In this exposé, particular attention is paid to the utility and features of 3rd Generation Antipsychotic dopamine (DA) D2-D3 agonists within an APP setting.