scholarly journals Breed-Predispositions to Cancer in Pedigree Dogs

2013 ◽  
Vol 2013 ◽  
pp. 1-23 ◽  
Author(s):  
Jane M. Dobson
Keyword(s):  
Cancer Susceptibility ◽  
Association Studies ◽  
Molecular Genetic ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Complex Disorders ◽  
Genome Wide ◽  
Increased Risk ◽  
Purebred Dogs ◽  
Limited Genetic Diversity

Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs may be affected, it is notable that some breeds of pedigree dogs appear to be at increased risk of certain types of cancer suggesting underlying genetic predisposition to cancer susceptibility. Although the aetiology of most cancers is likely to be multifactorial, the limited genetic diversity seen in purebred dogs facilitates genetic linkage or association studies on relatively small populations as compared to humans, and by using newly developed resources, genome-wide association studies in dog breeds are proving to be a powerful tool for unravelling complex disorders. This paper will review the literature on canine breed susceptibility to histiocytic sarcoma, osteosarcoma, haemangiosarcoma, mast cell tumours, lymphoma, melanoma, and mammary tumours including the recent advances in knowledge through molecular genetic, cytogenetic, and genome wide association studies.

Body size and composition and site-specific cancers in UK Biobank: a Mendelian randomisation study

2020 ◽  
Author(s):  
Mathew Vithayathil ◽  
Paul Carter ◽  
Siddhartha Kar ◽  
Amy M. Mason ◽  
Stephen Burgess ◽  
...  
Keyword(s):  
Instrumental Variables ◽  
Association Studies ◽  
Genome Wide Association ◽  
Mendelian Randomisation ◽  
Genome Wide Association Studies ◽  
Uk Biobank ◽  
Site Specific ◽  
Genome Wide ◽  
Increased Risk ◽  
The Uk

ABSTRACTObjectivesTo investigate the casual role of body mass index, body fat composition and height in cancer.DesignTwo stage mendelian randomisation studySettingPrevious genome wide association studies and the UK BiobankParticipantsGenetic instrumental variables for body mass index (BMI), fat mass index (FMI), fat free mass index (FFMI) and height from previous genome wide association studies and UK Biobank. Cancer outcomes from 367 586 participants of European descent from the UK Biobank.Main outcome measuresOverall cancer risk and 22 site-specific cancers risk for genetic instrumental variables for BMI, FMI, FFMI and height.ResultsGenetically predicted BMI (per 1 kg/m2) was not associated with overall cancer risk (OR 0.99; 95% confidence interval (CI) 0-98-1.00, p=0.105). Elevated BMI was associated with increased risk of stomach cancer (OR 1.15, 95% (CI) 1.05-1.26; p=0.003) and melanoma (OR 0.96, 95% CI 0.92-1.00; p=0.044). For sex-specific cancers, BMI was positively associated with uterine cancer (OR 1.08, 95% CI 1.01-1.14; p=0.015) but inversely associated with breast (OR 0.95, 95% CI 0.92-0.98; p=0.001), prostate (OR 0.95, 95% CI 0.92-0.99; p=0.007) and testicular cancer (OR 0.89, 95% CI 0.81-0.98; p=0.017). Elevated FMI (per 1 kg/m2) was associated with gastrointestinal cancer (stomach cancer OR 4.23, 95% CI 1.18-15.13, p=0.027; colorectal cancer OR 1.94, 95% CI 1.23-3.07; p=0.004). Increased height (per 1 standard deviation, approximately 6.5cm) was associated with increased risk of overall cancer (OR 1.06; 95% 1.04-1.09; p = 2.97×10-8) and most site-specific cancers with the strongest estimates for kidney, non-Hodgkin lymphoma, colorectal, lung, melanoma and breast cancer.ConclusionsThere is little evidence for BMI as a casual risk factor for cancer. BMI may have a causal role for sex-specific cancers, although with inconsistent directions of effect, and FMI for gastrointestinal malignancies. Elevated height is a risk factor for overall cancer and multiple site cancers.

Novel pancreatic cancer susceptibility loci discovered through genome-wide association studies

Pancreatology ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. S49
Author(s):  
Federico Canzian ◽  
Daniele Campa ◽  
Cosmeri Rizzato ◽  
Maarten F. Bijlsma ◽  
Hermann Brenner ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Susceptibility ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Susceptibility Loci ◽  
Genome Wide

Insights into the genetics of osteoporosis from recent genome-wide association studies

2011 ◽  
Vol 13 ◽  
Author(s):  
Hou-Feng Zheng ◽  
Timothy D. Spector ◽  
J. Brent Richards
Keyword(s):  
Rare Variants ◽  
Association Studies ◽  
Fragility Fractures ◽  
Fracture Prevention ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Mineral Density ◽  
Genome Wide ◽  
Increased Risk ◽  
Genetics Of Osteoporosis

Osteoporosis, which is characterised by reduced bone mineral density (BMD) and an increased risk of fragility fractures, is the result of a complex interaction between environmental factors and genetic variants that confer susceptibility. Heritability studies have shown that BMD and other osteoporosis-related traits such as ultrasound properties of bone, skeletal geometry and bone turnover have significant inheritable components. Although previous linkage and candidate gene studies have provided few replicated loci for osteoporosis, genome-wide association approaches have produced clear and reproducible findings. To date, 20 genome-wide association studies (GWASs) for osteoporosis and related traits have been conducted, identifying dozens of genes. Further meta-analyses of GWAS data and deep resequencing of rare variants will uncover more novel susceptibility loci and ultimately provide possible therapeutic targets for fracture prevention.

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