scholarly journals Scorpion Peptides: Potential Use for New Drug Development

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
BenNasr Hmed ◽  
Hammami Turky Serria ◽  
Zeghal Khaled Mounir
Keyword(s):  
Drug Development ◽  
Functional Diversity ◽  
Biological Activities ◽  
New Drugs ◽  
Biological Mechanisms ◽  
Neoplastic Diseases ◽  
New Drug ◽  
New Drug Development ◽  
Potential Use

Several peptides contained in scorpion fluids showed diverse array of biological activities with high specificities to their targeted sites. Many investigations outlined their potent effects against microbes and showed their potential to modulate various biological mechanisms that are involved in immune, nervous, cardiovascular, and neoplastic diseases. Because of their important structural and functional diversity, it is projected that scorpion-derived peptides could be used to develop new specific drugs. This review summarizes relevant findings improving their use as valuable tools for new drugs development.

The Effect of Price on Pharmaceutical R&D

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Abdulkadir Civan ◽  
Michael T. Maloney
Keyword(s):  
United States ◽  
Drug Development ◽  
Price Elasticity ◽  
The United States ◽  
Mortality Rates ◽  
New Drugs ◽  
New Drug ◽  
Development Pipeline ◽  
New Drug Development

Abstract This work extends prior research that finds drug development is driven by demand factors such as mortality rates of the diseases new drugs are aimed at. Here we find that the number of drugs in the development pipeline is strongly positively related to the price of existing drugs treating those diseases. This gives us a direct price elasticity measure from which we can draw some inference about the effect on new drug development that might occur if the pricing regime in the United States were to change.

A Review on Classification and Biological Activities of Alkaloids from the Genus Zanthoxylum Species

2020 ◽  
Vol 20 ◽  
Author(s):  
Wen-Jun Wei ◽  
Xiao-Hui Chen ◽  
Tao Guo ◽  
Xiao-Qian Liu ◽  
Yi Zhao ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Drug Development ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Biological Properties ◽  
Biological Study ◽  
New Drug ◽  
Wide Range ◽  
New Drug Development

: Many plants in the genus Zanthoxylum, belonging to the Rutaceae family, are recorded as folk medicines for the treatment of various diseases, which attracts much attention for their phytochemical and pharmacological activity investigations. Alkaloids are the largest secondary metabolites with structurally diverse types found in this genus and they demonstrate a wide range of biological activities. The aim of this review is to provide a summary on the isolation, classification, and biological properties of the alkaloids from Zanthoxylum species, which also will bring more attention to other researchers for further biological study on alkaloids for the new drug development.

Synthesis and Biological Activity of Hydrazones and Derivatives: A Review

2020 ◽  
Vol 20 (5) ◽  
pp. 342-368 ◽  
Author(s):  
Juliana de Oliveira Carneiro Brum ◽  
Tanos Celmar Costa França ◽  
Steven R. LaPlante ◽  
José Daniel Figueroa Villar
Keyword(s):  
Biological Activity ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
New Drugs ◽  
New Drug ◽  
Cancer Inflammation

Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer’s, cancer, inflammation, and leishmaniasis. However, most of the investigations on hydrazones available in literature today are directed to the synthesis of these molecules with little discussion available on their biological activities. With the purpose of bringing lights into this issue, we performed a revision of the literature and wrote this review based on some of the most current research reports of hydrazones and derivatives, making it clear that the synthesis of these molecules can lead to new drug prototypes. Our goal is to encourage more studies focused on the synthesis and evaluation of new hydrazones, as a contribution to the development of potential new drugs for the treatment of various diseases.

New Drug Development

2013 ◽  
pp. 1334-1334
Author(s):  
Jasmin Tiro ◽  
Simon J. Craddock Lee ◽  
Steven E. Lipshultz ◽  
Tracie L. Miller ◽  
James D. Wilkinson ◽  
...  
Keyword(s):  
Drug Development ◽  
New Drug ◽  
New Drug Development
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