scholarly journals Alleviation of Plasma Homocysteine Level by Phytoestrogenα-Zearalanol Might Be Related to the Reduction of Cystathionineβ-Synthase Nitration

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Hui Zhang ◽  
Qi Sun ◽  
Teng Liu ◽  
Lu Ma ◽  
Panpan Zhen ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Plasma Homocysteine Level ◽  
Rat Models ◽  
Nitrative Stress ◽  
Key Enzyme ◽  
Total Homocysteine ◽  
Underlying Mechanisms ◽  
Plasma Total Homocysteine

Hyperhomocysteinemia is strongly associated with cardiovascular diseases. Previous studies have shown that phytoestrogenα-zearalanol can protect cardiovascular system from hyperhomocysteinemia and ameliorate the level of plasma total homocysteine; however, the underlying mechanisms remain to be clarified. The aim of this research is to investigate the possible molecular mechanisms involved in ameliorating the level of plasma homocysteine byα-zearalanol. By the successfully established diet-induced hyperhomocysteinemia rat models, we found that, afterα-zearalanol treatment, the activity of cystathionineβ-synthase, the key enzyme in homocysteine metabolism, was significantly elevated and level of nitrative stress in liver was significantly reduced. In correlation with this, results also showed a decreased nitration level of cystathionineβ-synthase in liver. Together data implied that alleviation of plasma homocysteine level by phytoestrogenα-zearalanol might be related to the reduction of cystathionineβ-synthase nitration.

Association between total plasma homocysteine level and cognitive functions in elderly Egyptian subjects

2013 ◽  
Vol 332 (1-2) ◽  
pp. 86-91 ◽  
Author(s):  
Mahmoud Allam ◽  
Ebtesam Fahmy ◽  
Sahar Abd Elatti ◽  
Hanan Amer ◽  
Noha Abo-krysha ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Total Plasma ◽  
Plasma Homocysteine Level

Is Plasma Homocysteine Level Associated With Metabolic Syndrome Components in Adolescents?

2009 ◽  
Vol 7 (4) ◽  
pp. 357-362 ◽  
Author(s):  
Nurten Budak ◽  
Cevad Yazici ◽  
Ahmet Öztürk ◽  
Fahri Bayram ◽  
M. Mümtaz Mazıcıoğlu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Plasma Homocysteine Level ◽  
Metabolic Syndrome Components

scholarly journals Coronary Angiographic Severity in Patients With Raised Plasma Homocysteine Level

1970 ◽  
Vol 1 (2) ◽  
pp. 169-173 ◽  
Author(s):  
MS Kabir ◽  
AAs Majumder ◽  
MS Bari ◽  
AW Chowdhury ◽  
AM Islam
Keyword(s):  
Coronary Artery Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Ischaemic Heart Disease ◽  
Homocysteine Level ◽  
Plasma Homocysteine ◽  
Plasma Homocysteine Level ◽  
Vessel Disease ◽  
Artery Disease ◽  
Single Vessel Disease

Background: Besides conventional classic risk factors of ischaemic heart disease other variables that have come under scrutiny for their potential contribution include estrogen deficiency, lipoprotein (a), plasma fibrinogen, plasminogen-activator inhibitor type I, endogenous tissue plasminogen activator (tPA), C-reactive protein and homocysteine. A number of studies have been undertaken worldwide shows strong correlation of raised fasting plasma homocysteine level with the development of atherosclerotic vascular diseases, myocardial infarction or increasing severity of coronary artery diseases. Objective: To find out the correlation of fasting plama homocysteine level with the severity of coronary artery disease in our population. Method: We undertook a study involving 100 patients of ischaemic heart disease (determined clinically & by non-invasive tests) in National Institute of Cardiovascular Diseases, Dhaka, Bangladesh, over the period of one year from January 2003 to December 2003. Out of 100 patients, 50 patients having normal homocysteine level were considered as control and another 50 patients having raised plasma homocysteine level were taken as cases. Result: Out of 50 patients, 20% had single vessel disease, 48% had double vessel disease and 32% had 3 vessel diseases. On the other hand in control group 10% patients had normal coronary artery disease, 40% had single vessel disease, 32% had double vessel disease and 18% had triple vessel disease. Conclusion: The study showed significant increase in number of coronary artery involvement by atherosclerotic lesions with increasing levels of plasma homocysteine level. Key words: Homocysteine; Coronary artery disease; Coronary angiogram. DOI: http://dx.doi.org/10.3329/cardio.v1i2.8124 Cardiovasc. j. 2009; 1(2) : 169-173

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