scholarly journals Emotional Working Memory and Alzheimer’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Nicola Mammarella ◽  
Beth Fairfield
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Memory Performance ◽  
Memory Task ◽  
Emotional Information ◽  
Healthy Older Adults ◽  
Affective Stimuli ◽  
Age Related ◽  
Dementia Of Alzheimer’S Type

A number of recent studies have reported that working memory does not seem to show typical age-related deficits in healthy older adults when emotional information is involved. Differently, studies about the short-term ability to encode and actively manipulate emotional information in dementia of Alzheimer’s type are few and have yielded mixed results. Here, we review behavioural and neuroimaging evidence that points to a complex interaction between emotion modulation and working memory in Alzheimer’s. In fact, depending on the function involved, patients may or may not show an emotional benefit in their working memory performance. In addition, this benefit is not always clearly biased (e.g., towards negative or positive information). We interpret this complex pattern of results as a consequence of the interaction between multiple factors including the severity of Alzheimer’s disease, the nature of affective stimuli, and type of working memory task.

scholarly journals Working Memory and the Enactment Effect in Early Alzheimer’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Lara A. Charlesworth ◽  
Richard J. Allen ◽  
Suzannah Morson ◽  
Wendy K. Burn ◽  
Celine Souchay
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Free Recall ◽  
Older Adult ◽  
Memory Task ◽  
Enactment Effect ◽  
The Subject ◽  
Instruction Sequences ◽  
Early Alzheimer’S Disease

This study examines the enactment effect in early Alzheimer’s disease using a novel working memory task. Free recall of action-object instruction sequences was measured in individuals with Alzheimer’s disease (n=14) and older adult controls (n=15). Instruction sequences were read out loud by the experimenter (verbal-only task) or read by the experimenter and performed by the participants (subject-performed task). In both groups and for all sequence lengths, recall was superior in the subject-performed condition than the verbal-only condition. Individuals with Alzheimer’s disease showed a deficit in free recall of recently learned instruction sequences relative to older adult controls, yet both groups show a significant benefit from performing actions themselves at encoding. The subject-performed task shows promise as a tool to improve working memory in early Alzheimer’s disease.

Effects of repetitive paired associative stimulation on brain plasticity and working memory in Alzheimer’s disease: a pilot randomized double-blind-controlled trial

2020 ◽  
pp. 1-13
Author(s):  
Sanjeev Kumar ◽  
Reza Zomorrodi ◽  
Zaid Ghazala ◽  
Michelle S. Goodman ◽  
Daniel M. Blumberger ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Brain Plasticity ◽  
Controlled Trial ◽  
Memory Performance ◽  
Double Blind ◽  
Paired Associative Stimulation ◽  
Post Hoc ◽  
The Impact

ABSTRACT Design: Pilot randomized double-blind-controlled trial of repetitive paired associative stimulation (rPAS), a paradigm that combines transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex (DLPFC) with peripheral median nerve stimulation. Objectives: To study the impact of rPAS on DLPFC plasticity and working memory performance in Alzheimer’s disease (AD). Methods: Thirty-two patients with AD (females = 16), mean (SD) age = 76.4 (6.3) years were randomized 1:1 to receive a 2-week (5 days/week) course of active or control rPAS. DLPFC plasticity was assessed using single session PAS combined with electroencephalography (EEG) at baseline and on days 1, 7, and 14 post-rPAS. Working memory and theta–gamma coupling were assessed at the same time points using the N-back task and EEG. Results: There were no significant differences between the active and control rPAS groups on DLPFC plasticity or working memory performance after the rPAS intervention. There were significant main effects of time on DLPFC plasticity, working memory, and theta–gamma coupling, only for the active rPAS group. Further, on post hoc within-group analyses done to generate hypotheses for future research, as compared to baseline, only the rPAS group improved on post-rPAS day 1 on all three indices. Finally, there was a positive correlation between working memory performance and theta–gamma coupling. Conclusions: This study did not show a beneficial effect of rPAS for DLPFC plasticity or working memory in AD. However, post hoc analyses showed promising results favoring rPAS and supporting further research on this topic. (Clinicaltrials.gov-NCT01847586)

scholarly journals Time‐frequency analysis in a working memory task in pre‐clinical stage and symptomatic stage of Alzheimer’s disease

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Sandra Doval ◽  
Noelia Serrano ◽  
David López Sanz ◽  
Ricardo Bruña Fernández ◽  
María Luisa Delgado Losada ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Frequency Analysis ◽  
Clinical Stage ◽  
Memory Task ◽  
Time Frequency Analysis ◽  
Time Frequency

scholarly journals Effect of cortisol levels on working memory performance in elderly subjects with Alzheimer's disease

2008 ◽  
Vol 66 (3b) ◽  
pp. 619-624 ◽  
Author(s):  
Juliana Nery de Souza-Talarico ◽  
Paulo Caramelli ◽  
Ricardo Nitrini ◽  
Eliane Corrêa Chaves
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Digit Span ◽  
Memory Performance ◽  
Elderly Subjects ◽  
Control Group ◽  
Acute Administration ◽  
Healthy Elderly ◽  
Cortisol Levels

BACKGROUND: Subjects with Alzheimer's disease (AD) have elevated cortisol levels as a result of hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Acute administration of hydrocortisone has been associated with working memory (WM) performance in young adults. OBJECTIVE: To investigate whether cortisol levels are associated with WM performance in subjects with AD. METHOD: Eighty subjects were included, comprising 40 patients with mild AD and 40 healthy elderly controls. WM was assessed using the Digit Span Backward test (DSB). Saliva samples were collected to determine cortisol levels. RESULTS: AD subjects had poorer performance on the DSB than controls (p=0.002) and also presented higher levels of cortisol than control group (p=0.04). No significant correlation was observed between the DSB and cortisol levels in both groups (r= -0.29). CONCLUSION: In this study, elevated cortisol levels were not associated with poorer WM performance in patients with AD or in healthy elderly subjects.

P3-348: Coping strategies may vary according to working memory performance in individuals with Alzheimer's disease

2011 ◽  
Vol 7 ◽  
pp. S626-S626
Author(s):  
Juliana Souza-Talarico ◽  
Eliane Chaves ◽  
Ricardo Nitrini ◽  
Paulo Caramelli
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Coping Strategies ◽  
Memory Performance

311. DLPFC Neuroplasticity and Working Memory Performance in Alzheimer’s Disease

2017 ◽  
Vol 81 (10) ◽  
pp. S128
Author(s):  
Sanjeev Kumar ◽  
Reza Zomorrodi ◽  
Zaid Ghazala ◽  
Michelle Goodman ◽  
Amay Cheam ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Memory Performance

EEG synchronization likelihood in mild cognitive impairment and Alzheimer's disease during a working memory task

2004 ◽  
Vol 115 (6) ◽  
pp. 1332-1339 ◽  
Author(s):  
Y.A.L. Pijnenburg ◽  
Y. vd Made ◽  
A.M. van Cappellen van Walsum ◽  
D.L. Knol ◽  
Ph. Scheltens ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Task ◽  
Synchronization Likelihood

scholarly journals Evaluation of Episodic and Lexical Metamemory and Executive Function in Healthy Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 704-705
Author(s):  
Atsuko Hayashi
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
Episodic Memory ◽  
Stroop Task ◽  
Memory Performance ◽  
Memory Task ◽  
Lexical Memory ◽  
Healthy Older Adults ◽  
Self Evaluation ◽  
Age Related

Abstract In older adults, it is important to maintain awareness of memory as well as memory performance. However, it is not clear whether the awareness of episodic and lexical memory changes with age and is related to self-evaluation of memory and executive function. Here age-related changes and the relationship between metamemory, executive function, and metamemory scale were investigated. Healthy old (n=40) and young (n=34) groups participated in this study. In the episodic memory task, participants were asked to memorize ten Kanji words and to estimate the number of words they could recall after ten minutes. In the lexical memory task, they rated the likelihood that they could write a target Kanji word written in hiragana and then wrote them down. They were also asked to complete the metamemory in adulthood(MIA) and the position stroop task. In the episodic and lexical memory and the position stroop task and MIA subscales, the performances of the younger group were significantly better than those of the older group. In the episodic memory task, there were correlations between the metamemory and MIA subscales in both groups, but in the lexical memory task, only in the old group. No correlation was found between the results of both memory tasks and the stroop test. These results suggest that older people overestimate memory performances in the episodic and lexical memory tasks and metamemory performances may be associated with self-evaluation of memory. In addition, metamemory might not be related to frontal lobe function as shown in executive function tasks.

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